Hippocampal-prefrontal dynamics in spatial working memory: Interactions and independent parallel processing

Churchwell, John C.; Kesner, Raymond P.

doi:10.1016/j.bbr.2011.07.045

Cited by 122 publications

(87 citation statements)

References 55 publications

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“…This hypothesis seems to be supported by a previous study, which showed that the intermediate CA1 region of the hippocampus and the medial prefrontal cortex interact in coordinating RM and PM processes in anticipation of obtaining a remote goal [67]. Earlier neurocognitive studies suggested that dopaminergic modulation of hippocampal-prefrontal cortical interaction plays a key role in PM.…”

Section: Discussionsupporting

confidence: 55%

Prospective Memory Performance in Non-Psychotic First-Degree Relatives of Patients with Schizophrenia: A Controlled Study

et al. 2014

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ObjectiveWe aimed at investigating prospective memory and its socio-demographic and neurocognitive correlates in non-psychotic, first-degree relatives (FDRs) of patients with schizophrenia compared to patients with first episode schizophrenia (FES), and healthy controls (HCs).MethodsForty-seven FES patients, 50 non-psychotic FDRs (23 offspring and 27 siblings) of patients with chronic schizophrenia (unrelated to the FES group) and 51 HCs were studied. The Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT) was used to measure time-based prospective memory (TBPM) and event-based prospective memory (EBPM) performance. Other cognitive functions (involving respective memory and executive functions) were evaluated with standardized tests.ResultsAfter controlling for basic demographic characteristics including age, gender and educational level, there was a significant difference between FDRs, FES and HCs with respect to both TBPM (F(2,142) = 10.4, p<0.001) and EBPM (F(2,142) = 10.8, p<0.001). Multiple linear regression analyses revealed that lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the STROOP Word-Color Test (SWCT) contributed to TBPM impairment, while lower educational level and higher scores of the Color Trails Test-2 (CTT-2) contributed to EBPM deficit in FDRs.ConclusionsFDRs share similar but attenuated prospective memory impairments with schizophrenia patients, suggesting that prospective memory deficits may represent an endophenotype of schizophrenia.

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Section: Discussionsupporting

confidence: 55%

Prospective Memory Performance in Non-Psychotic First-Degree Relatives of Patients with Schizophrenia: A Controlled Study

et al. 2014

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“…Recent evidence suggests that these structures mutually interact to process memory/working memory (WM). For instance, it has been shown that inactivation of either structure, or their disconnection, impairs spatial working memory (Floresco et al, 1997; Lee and Kesner, 2003; Yoon et al, 2008; Churchwell et al, 2010; Churchwell and Kesner, 2011; Griffin, 2015). In addition, the two structures show coherent activity during the performance of certain working memory tasks (Jones and Wilson, 2005; Colgin, 2011; Gordon, 2011; O'Neill et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Lesions of the ventral midline thalamus produce deficits in reversal learning and attention on an odor texture set shifting task

2016

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The nucleus reuniens (RE) of the ventral midline thalamus in strongly reciprocally connected with the hippocampus (HF) and the medial prefrontal cortex (mPFC) and has been shown to mediate the transfer of information between these structures. It has become increasingly well established that RE serves a critical role in mnemonic tasks requiring the interaction of the HF and mPFC, but not tasks relying solely on the HF. Very few studies have addressed the independent actions of RE on prefrontal executive functioning. The present report examined the effects of lesions of the ventral midline thalamus, including RE and the dorsally adjacent rhomboid nucleus (RH) in rats on attention and behavioral flexibility using the attentional set shifting task (AST). The task uses odor and tactile stimuli to test for attentional set formation, attentional set shifting, behavioral flexibility and reversal learning. By comparison with sham controls, lesioned rats were significantly impaired on reversal learning and intradimensional (ID) set shifting. Specifically, RE/RH lesioned rats were impaired on the first reversal stage of the task which required a change in response strategy to select a previously non-rewarded stimulus for reward. RE/RH lesioned rats also exhibited deficits in the ability to transfer or generalize rules of the task which consists of making the same modality-based choices (e.g., odor vs. tactile) to different sets of stimuli in the ID stage of the task. These results demonstrate that in addition to its role in tasks dependent on HF-mPFC interactions, RE/RH is also critically involved cognitive/executive functions associated with the medial prefrontal cortex. As such, the deficits in the AST task produced by RE/RH lesions suggest the ventral midline thalamus directly contributes to flexible goal directed behavior.

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“…This function would be important for maintaining goal-directed behavior over time to meet one's needs, so it could be considered important in governing sustained attention. Finally, the lateral regions appear to be important in providing emotional tone during memory EVALUATING VENTRAL-MEDIAL SYSTEM ATTENTION encoding and retrieval (e.g., orbital-hippocampus; Churchwell & Kesner, 2011;Hoover & Vertes, 2011). With evidence suggesting memory function is impaired during excessive or minimal emotional states as discussed earlier, this function could influence how individuals acquire and use memory in adaptive ways for goal-directed behavior (Young & Shapiro, 2011).…”

Section: Moving Beyond the Cortico-centric ''Cool'' Dorsal And ''Hot'mentioning

confidence: 96%

Evaluating Orbital-Ventral Medial System Regulation of Personal Attention: A Critical Need for Neuropsychological Assessment and Intervention

Hale

Fitzer

2015

Applied Neuropsychology: Child

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Attention to self and environment form the basis of effective social exchange and relationships. Although implicit in this basic social competency is the ability to be self-aware and responsive to the circumstances of others, many neuropsychologists have yet to understand or measure its basic functions, let alone recognize the brain-behavior relationships that govern this area. Several years ago, interest in "emotional intelligence" rose to the forefront of popular psychology, but we are still unraveling the cortical, subcortical, and neurocellular interactions that produce this nebulous construct, and we are determining how dysfunctional frontal-subcortical and cortico-cerebellar circuitry can lead to aberrant social dynamics and ultimately psychopathology when maladaptive patterns become routinized. In this article, we explore the orbital-ventral medial circuitry thought to govern emotional attention, personal self-regulation, social concern and exchange, and affective aspects of interpersonal relationships. Our examination notes both the dearth of and need for neuropsychological research on the biological basis and measurement of executive regulation of emotional attention, behavioral regulation, and social competence. We conclude with a call for development of neuropsychological measures and methods that can foster differential diagnosis and targeted treatment strategies for children with orbital-ventral medial circuit dysfunction.

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Hippocampal-prefrontal dynamics in spatial working memory: Interactions and independent parallel processing

Cited by 122 publications

References 55 publications

Prospective Memory Performance in Non-Psychotic First-Degree Relatives of Patients with Schizophrenia: A Controlled Study

Prospective Memory Performance in Non-Psychotic First-Degree Relatives of Patients with Schizophrenia: A Controlled Study

Lesions of the ventral midline thalamus produce deficits in reversal learning and attention on an odor texture set shifting task

Evaluating Orbital-Ventral Medial System Regulation of Personal Attention: A Critical Need for Neuropsychological Assessment and Intervention

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