Hippocampal place cells are topographically organized, but physical space has nothing to do with it

França, Thiago F. A.; Monserrat, José M.

doi:10.1007/s00429-019-01968-9

Cited by 7 publications

(5 citation statements)

References 74 publications

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“…ref. 37 ), we hypothesized that cue ensembles may exhibit a higher level of topographic clustering, whereas trajectory ensemble neurons may be more diffuse. We began by examining the distribution of cells’ tendencies for encoding either cue or spatial locations, for all spatially-selective neurons.…”

Section: Resultsmentioning

confidence: 99%

Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue

Chang,

Esteves,

Neumann

et al. 2023

Nat Commun

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Episodic memories comprise diverse attributes of experience distributed across neocortical areas. The hippocampus is integral to rapidly binding these diffuse representations, as they occur, to be later reinstated. However, the nature of the information exchanged during this hippocampal-cortical dialogue remains poorly understood. A recent study has shown that the secondary motor cortex carries two types of representations: place cell-like activity, which were impaired by hippocampal lesions, and responses tied to visuo-tactile cues, which became more pronounced following hippocampal lesions. Using two-photon Ca2+ imaging to record neuronal activities in the secondary motor cortex of male Thy1-GCaMP6s mice, we assessed the cortical retrieval of spatial and non-spatial attributes from previous explorations in a virtual environment. We show that, following navigation, spontaneous resting state reactivations convey varying degrees of spatial (trajectory sequences) and non-spatial (visuo-tactile attributes) information, while reactivations of non-spatial attributes tend to precede reactivations of spatial representations surrounding hippocampal sharp-wave ripples.

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Section: Resultsmentioning

confidence: 99%

Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue

Chang,

Esteves,

Neumann

et al. 2023

Nat Commun

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“…We previously mentioned that the place cells fire whenever the animal is in a specific place field and these cells are distributed within the hippocampus in a way that covers the whole environment the animal occupies. This distribution within the hippocampus will cause a certain degree of overlap between the place fields, thus a population of cells will respond when the animal goes into the field rather than an individual cell since the cells in the hippocampus are receiving multiple sensory inputs to encode a multidimensional map ( 44 ).…”

Section: Population Codingmentioning

confidence: 99%

Mechanisms for Cognitive Impairment in Epilepsy: Moving Beyond Seizures

2022

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There has been a major emphasis on defining the role of seizures in the causation of cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative hypothesis behind these deficits, emphasizing the mechanisms of information processing underlying healthy cognition characterized as rate, temporal and population coding. We discuss the role of the underlying etiology of epilepsy in altering neural networks thereby leading to both the propensity for seizures and the associated cognitive impairments. In addition, we address potential treatments that can recover the network function in the context of a diseased brain, thereby improving both seizure and cognitive outcomes simultaneously. This review shows the importance of moving beyond seizures and approaching the deficits from a system-level perspective with the guidance of network neuroscience.

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“…This topological arrangement could change if a different kind of connectomics is used, leading to a sparsification of the neurons encoding similar information (Diehl and Cook, 2015;Hazan et al, 2018). While it is still debated if the hippocampus has a topological organization of the information (França and Monserrat, 2019), computational models employing the actual connectomics of the neuronal populations could shed light on the topic.…”

Section: Limitations and Future Workmentioning

confidence: 99%

A neuro-inspired computational model of life-long learning and catastrophic interference, mimicking hippocampus novelty-based dopamine modulation and lateral inhibitory plasticity

Afferni

Cascino-Milani

Mattera

et al. 2022

Front. Comput. Neurosci.

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The human brain has a remarkable lifelong learning capability to acquire new experiences while retaining previously acquired information. Several hypotheses have been proposed to explain this capability, but the underlying mechanisms are still unclear. Here, we propose a neuro-inspired firing-rate computational model involving the hippocampus and surrounding areas, that encompasses two key mechanisms possibly underlying this capability. The first is based on signals encoded by the neuromodulator dopamine, which is released by novel stimuli and enhances plasticity only when needed. The second is based on a homeostatic plasticity mechanism that involves the lateral inhibitory connections of the pyramidal neurons of the hippocampus. These mechanisms tend to protect neurons that have already been heavily employed in encoding previous experiences. The model was tested with images from the MNIST machine learning dataset, and with more naturalistic images, for its ability to mitigate catastrophic interference in lifelong learning. The results show that the proposed biologically grounded mechanisms can effectively enhance the learning of new stimuli while protecting previously acquired knowledge. The proposed mechanisms could be investigated in future empirical animal experiments and inspire machine learning models.

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Hippocampal place cells are topographically organized, but physical space has nothing to do with it

Cited by 7 publications

References 74 publications

Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue

Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue

Mechanisms for Cognitive Impairment in Epilepsy: Moving Beyond Seizures

A neuro-inspired computational model of life-long learning and catastrophic interference, mimicking hippocampus novelty-based dopamine modulation and lateral inhibitory plasticity

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