volume 29, issue 2, P293-308 2012
DOI: 10.3233/jad-2011-110830
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Slavica Krantic, Nathalie Isorce, Naguib Mechawar, Maria Antonietta Davoli, Erika Vignault, Marilia Albuquerque, Jean-Guy Chabot, Emmanuel Moyse, Jean-Pierre Chauvin, Isabelle Aubert, JoAnne McLaurin, Rémi Quirion

Abstract: The relevance of γ-amino-butyric acid (GABA)-ergic dysfunctions in the pathology of Alzheimer's disease (AD) remains a matter of debate. In the present study, we characterized the toxicity of amyloid-β (Aβ) on hippocampal GABAergic neurons both in vivo and in vitro. In the TgCRND8 mouse model of AD, we found a significant decrease in the number of hippocampal neurons immunoreactive for glutamate decarboxylase 67 (GAD67), the enzyme synthesizing GABA. This decrease, which was specific for hippocampal CA1-3 fiel…

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