Highly uniform porous silica layer open-tubular capillary columns produced via in-situ biphasic sol–Gel processing for open-tubular capillary electrochromatography

Liu, Xin; Sun, Shucheng; Nie, Rongbin; Ma, Jianjun; Qu, Qishu; Yang, Li

doi:10.1016/j.chroma.2018.01.024

Cited by 31 publications

(25 citation statements)

References 33 publications

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“…Silica‐based materials continue to be utilized in separation science because of their good chemical stability, and diverse and accessible chemical modifications . Liu and co‐workers developed a single step in situ biphasic reaction to fabricate a silica‐based porous layer open tubular (PLOT) column, which could easily to control the stationary phase properties and achieve good performance of OT‐CEC separations of complicated peptide products. Jana et al.…”

Section: Open‐tubular Capillary Electrochromatographymentioning

confidence: 99%

Recent developments of monolithic and open‐tubular capillary electrochromatography (2017–2019)

Yin

Zhang

et al. 2020

J of Separation Science

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Capillary electrochromatography, which combined the high selectivity of highperformance liquid chromatography and the high separation efficiency of capillary electrophoresis, is an attractive separation tool. In this review, the developments on monolithic and open tubular capillary electrochromatography during 2017 to August 2019 are summarized. Considering the development of novel stationary phases is the most active research field in capillary electrochromatography, monolithic capillary electrochromatography is classified according to the polymer-based and hybrid monolithic columns, while open-tubular capillary electrochromatography is categorized by cyclodextrin, silica, polymer, nanomaterials, microporous materials, and biomaterials-based open tubular columns. K E Y W O R D S

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Section: Open‐tubular Capillary Electrochromatographymentioning

confidence: 99%

Recent developments of monolithic and open‐tubular capillary electrochromatography (2017–2019)

Yin

Zhang

et al. 2020

J of Separation Science

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“…Liu et al. [43] developed a highly uniform porous layer open tubular (PLOT) column using a single-step in-situ biphasic reaction which could efficiently achieve the control of the stationary phase properties such as thickness, morphology and distribution of pores. The stationary phase, a porous-layer with ∼240 nm thickness, was modified on the inner wall of the capillary.…”

Section: Open-tubular Columnmentioning

confidence: 99%

“…[44] synthesized a silica sol-gel containing porphyrin-brucine conjugate as stationary phases for the analysis of biologically compounds including oligopeptides, nucleobases, nucleosides and nucleotides. Compared to the sol–gel stationary phases just possessing Si– O –Si structure [43], the introduction of porphyrin-brucine conjugate obviously enhances the separation performance. The incorporation of an appropriate modifier into sol–gel stationary phases provides a new idea for the development of silica-based materials.…”

Section: Open-tubular Columnmentioning

confidence: 99%

“…The separations of small organic molecules consisting of alkylbenzenes [12,13,25,27,28,32,48,50,52,54,58,64,66], PAHs [18,28,37,43,48,52,[63], [64], [65]], chlorobenzenes [13,14,32,50], aromatic acids [13,39,49,53,54], phenols [14,15,17,18,48,50,52,53,58,59,62,68], anilines [12,25,28,39,48,52,62,64], parabens [29] and organophosphorus pesticides [54] have been investigated, while the separations of drugs such as cephalosporin antibiotics [20,29], impurities of pramipexole [57], sulfonamides [29,32,54] and non-steroidal anti-inflammatory drugs [27,32,63], especially the plant natural ingredients including purine alkaloids [55], flavonoids [16] and phenoxyacids [14,56], have been achieved. Biological molecules, amino acids [27,32,50], peptides [32,35,44,53], nucleotides [57], nucleosides [32,44,57], nucleobases [44,59], monoamine neurotransmitters [16] and proteins [[36], [37],…”

Section: Applicationsmentioning

confidence: 99%

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Advances in capillary electro-chromatography

Mao

Chen

2019

Journal of Pharmaceutical Analysis

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Capillary electrochromatography (CEC) is a micro-scale separation technique which is a hybrid between capillary electrophoresis (CE) and liquid chromatography (LC). CEC can be performed in packed, monolithic and open-tubular columns. In recent three years (from 2016 to 2018), enormous attention for CEC has been the development of novel stationary phases. This review mainly covers the development of novel stationary phases for open-tubular and monolithic columns. In particular, some biomaterials attracted increasing interest. There are no significant breakthroughs in technology and principles in CEC. The typical CEC applications, especially chiral separations are described.

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“…Capillary electrochromatography (CEC), combines the advantages of HPLC with those of CE, is a powerful tool for enantioseparations . For CEC analysis, the preparation of a capillary particularly immobilization the inner walls of the capillary, open tubular capillary electrochromatography (OTCEC) is obtained.…”

Section: Introductionmentioning

confidence: 99%

A novel open‐tubular capillary electrochromatography using carboxymethyl‐β‐cyclodextrin functionalized gold nanoparticles as chiral stationary phase

Zhang

et al. 2019

J of Separation Science

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Enantioselective open tubular capillary electrochromatography with carboxymethyl‐β‐cyclodextrin conjugated gold nanoparticles as stationary phase was developed. This novel open tubular column was fabricated through layer‐by‐layer self‐assembly of gold nanoparticles on a 3‐mercaptopropyl‐trimethoxysilane‐modified fused‐silica capillary and subsequent surface functionalization of the gold nanoparticles through self‐assembly of 6‐mercapto‐β‐cyclodextrin. The 6‐mercapto‐β‐cyclodextrin was firstly synthesized and determined by extensive spectroscopic data. Scanning electron microscopy, energy dispersive X‐ray analysis spectroscopy, and electroosmotic flow experiments were carried out to characterize the prepared open tubular column. Then, the separation effectiveness of the open tubular column was verified by two pairs of ɑ‐tetralones derivatives enantiomers and two pairs of basic drug enantiomers (tramadol hydrochloride and zopiclone) as mode analytes. Factors that influence the enantioseparation were optimized, and under the optimized conditions, satisfactory separation results were obtained for the four enantiomers: compound A, compound B, tramadol hydrochloride, and zopiclone with resolutions of 3.79, 1.56, 1.03, 1.60, respectively. For the combination of gold nanoparticles and negatively charged carboxymethyl‐β‐cyclodextrin, the open tubular column exhibited wider separation range for neutral and basic drugs. Moreover, the repeatability and stability of the column were studied through the run‐to‐run and day‐to‐day investigations.

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Highly uniform porous silica layer open-tubular capillary columns produced via in-situ biphasic sol–Gel processing for open-tubular capillary electrochromatography

Cited by 31 publications

References 33 publications

Recent developments of monolithic and open‐tubular capillary electrochromatography (2017–2019)

Recent developments of monolithic and open‐tubular capillary electrochromatography (2017–2019)

Advances in capillary electro-chromatography

A novel open‐tubular capillary electrochromatography using carboxymethyl‐β‐cyclodextrin functionalized gold nanoparticles as chiral stationary phase

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