Highly Stretchable, Strain Sensing Hydrogel Optical Fibers

Guo, Jingjing; Liu, Xinyue; Jiang, Nan; Yetisen, Ali K.; Yuk, Hyunwoo; Yang, Changxi; Khademhosseini, Ali; Zhao, Xuanhe; Yun, Seok Hyun

doi:10.1002/adma.201603160

Cited by 375 publications

(315 citation statements)

References 34 publications

Supporting

Mentioning

290

Contrasting

Order By: Relevance

“…Furthermore, these values are one up to two orders of magnitude lower in the decibel scale than those published so far for bioresorbable optical fibers, thus showing the advantage in using phosphate glass based optical waveguides for bioresorbable optics [7,9,10,14,15].…”

mentioning

confidence: 55%

“…Enhancing and characterizing the optical properties of opportune compositions of CPGs allowed overcoming some of the limitations of polymers, such as high attenuation and poor transparency in the blue and near UV region [13]. Using CPGs, the feasibility of bioresorbable optical fibers was previously demonstrated, with attenuation loss coefficients of 1.9 and 4.7 dB m À1 , at 1300 and 633 nm, respectively, that are 1 to 2 orders of magnitude lower as compared to what reported so far for bioresorbable waveguides [7,8,10,14,15]. The availability of bioresorbable fibers can open new perspectives in clinical applications.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Sieno

Boetti

Mora

et al. 2017

Journal of Biophotonics

View full text Add to dashboard Cite

In the last years bioresorbable materials are gaining increasing interest for building implantable optical components for medical devices. In this work we show the fabrication of bioresorbable optical fibers designed for diffuse optics applications, featuring large core diameter (up to 200 mm) and numerical aperture (0.17) to maximize the collection efficiency of diffused light. We demonstrate the suitability of bioresorbable fibers for timedomain diffuse optical spectroscopy firstly checking the intrinsic performances of the setup by acquiring the instrument response function. We then validate on phantoms the use of bioresorbable fibers by applying the MEDPHOT protocol to assess the performance of the system in measuring optical properties (namely, absorption and scattering coefficients) of homogeneous media. Further, we show an ex-vivo validation on a chicken breast by measuring the absorption and scattering spectra in the 500-1100 nm range using interstitially inserted bioresorbable fibers. This work represents a step toward a new way to look inside the body using optical fibers that can be implanted in patients. These fibers could be useful either for diagnostic (e. g. for monitoring the evolution after surgical interventions) or treatment (e. g. photodynamic therapy) purposes. Picture: Microscopy image of the 100 mm core bioresorbable fiber.

show abstract

mentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Sieno

Boetti

Mora

et al. 2017

Journal of Biophotonics

View full text Add to dashboard Cite

show abstract

“…[43] Additionally, the development of cladding methods that can bound to the core covalently will improve performance in vivo . [44] …”

Section: Hydrogel Optical Fiber Sensorsmentioning

confidence: 99%

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

et al. 2017

Self Cite

View full text Add to dashboard Cite

Optical fibers are widely used in biomedical applications for sensing, imaging, and therapies. Unlike existing solid-state optical fibers, soft polymer and hydrogel fibers offer physical and chemical properties well suited for functionalization with biomolecules and long-term implantation in the body. Here, hydrogel optical fibers are fabricated with glucose-sensitive moieties and the swelling-induced sensing is demonstrated. The core of the fiber is made of poly(acrylamide-co-poly(ethylene glycol) diacrylate) (p(AM-co-PEGDA)) hydrogel functionalized with phenylboronic acid. The complexation of the phenylboronic acid and cis diols of glucose molecules lowers the apparent pKa of the hydrogel network and increases the concentration of the boronate anions that enhances the Donnan osmotic pressure to swell and change the physical size of the hydrogel optical fiber. This mechanism is reversible through ester group dynamic covalent binding of the phenylboronic acid with glucose molecules. Dynamic changes in the effective RI of the hydrogel optical fiber are measured through light propagation loss. The sensor sensitivity to glucose concentration is 1.2 mmol L−1 over a physiological range of 1–12 mmol L−1. The biocompatible hydrogel optical fibers may be subcutaneously implanted for continuous monitoring of interstitial glucose concentrations.

show abstract

“…However, by the miniaturization of the measuring unit and embedding wireless transmission technologies, remote sensing of the oil contraminants in the environment can be achieved. Furthermore, the present sensing technology can be integrated with optical fibers [24][25][26][27], waveguides, [28] optical resonators, [29] and smartphone readers [30,31] …”

Section: Resultsmentioning

confidence: 99%

Three-Dimensional Microstructured Lattices for Oil Sensing

et al. 2017

Self Cite

View full text Add to dashboard Cite

Monitoring of environmental contamination including oil pollution is important to protect marine ecosystems. A wide range of sensors are utilized in petroleum industry to measure various parameters such as viscosity, pressure, and flow. Here, we create an optical lattice mesh structure that can be used as an oil sensor integrated with optical fiber probing. The principle of operation of the sensor was based on light scattering, where the tested medium acted as a diffuser. Three different mesh-sized structures were analyzed by optical imaging, light transmission and scattering in the presence of supercut, diesel and stroke oil types within the meshes. The meshes were utilized as a medium for different types of oils and the optical diffusion and transmission were studied in the visible spectrum. Angle-resolved measurements were carried out to characterize light scattering behavior from the mesh structures. Different types of oils were identified based on the optical behavior of the lattice structure. The fabricated mesh structures can be utilized as a low-cost measurement device in oil sensing.

show abstract

Highly Stretchable, Strain Sensing Hydrogel Optical Fibers

Cited by 375 publications

References 34 publications

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

Three-Dimensional Microstructured Lattices for Oil Sensing

Contact Info

Product

Resources

About