Highly sensitive detection of multiple tumor markers for lung cancer using gold nanoparticle probes and microarrays

Gao, Wanlei; Wang, Wentao; Yao, Shihua; Wu, Shan; Zhang, Honglian; Zhang, Jishen; Fu, Jing; Mao, Hongju; Jin, Qinghui; Cong, Hui; Jia, Chunping; Zhang, Guojun; Zhao, Jianlong

doi:10.1016/j.aca.2016.12.016

Cited by 44 publications

(21 citation statements)

References 25 publications

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“…More recently, a different solution based on the color change of gold nanoparticles coated with antigens has been introduced [15]. The limit of detection of this sensor was less than 1 ng/mL.…”

Section: Biosensors For Biomarkersmentioning

confidence: 99%

Sensors for Lung Cancer Diagnosis

Capuano

Catini

Paolesse

et al. 2019

JCM

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The positive outcome of lung cancer treatment is strongly related to the earliness of the diagnosis. Thus, there is a strong requirement for technologies that could provide an early detection of cancer. The concept of early diagnosis is immediately extended to large population screening, and then, it is strongly related to non-invasiveness and low cost. Sensor technology takes advantage of the microelectronics revolution, and then, it promises to develop devices sufficiently sensitive to detect lung cancer biomarkers. A number of biosensors for the detection of cancer-related proteins have been demonstrated in recent years. At the same time, the interest is growing towards the analysis of volatile metabolites that could be measured directly from the breath. In this paper, a review of the state-of-the-art of biosensors and volatile compound sensors is presented.

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Section: Biosensors For Biomarkersmentioning

confidence: 99%

Sensors for Lung Cancer Diagnosis

Capuano

Catini

Paolesse

et al. 2019

JCM

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“…The microarray based systems, in particular the MIDTAL system, show great promise to allow for detection of a high number of HAS in-tandem. The main disadvantage of such microarrays is detection sensitivity, however, a number of strategies may be employed to increase such sensitivity [41,42]. Other disadvantages, such as sample extraction and handling, may be addressed through the use of automated microfluidics [43].…”

Section: Biosensors To Detect Harmful Algal Speciesmentioning

confidence: 99%

Biosensors for the monitoring of harmful algal blooms

McPartlin

Loftus

Crawley

et al. 2017

Current Opinion in Biotechnology

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Harmful algal blooms (HABs) are a major global concern due to their propensity to cause environmental damage, healthcare issues and economic losses. In particular, the presence of toxic phytoplankton is a cause for concern. Current HAB monitoring programs often involve laborious laboratory-based analysis at a high cost and with long turnaround times. The latter also hampers the potential to develop accurate and reliable models that can predict HAB occurrence. However, a promising solution for this issue may be in the form of remotely deployed biosensors, which can rapidly and continuously measure algal and toxin levels at the point-of-need (PON), at a low cost. This review summarises the issues HABs present, how they are difficult to monitor and recently developed biosensors that may improve HAB-monitoring challenges.

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“…The rapid simultaneous detection of multiple cancer biomarkers in body fluids could help confirm lung cancer as soon as possible, so as to provide scientific reference for clinical treatment (Xu et al 2017). However, the determination of a single tumor marker usually has a limiting clinical reference value (Gao et al 2017;Lu et al 2015). Thus, simultaneous detection of two or more biomarkers, with high sensitivity and specificity, has gained lots of attention recently (Jia et al 2014).…”

Section: Introductionmentioning

confidence: 99%