volume 9, issue 4, P875-901 2003
DOI: 10.1017/s1357321700004396
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A. S. Macdonald, S. Y. Yang

Abstract: abstractFor estimates of critical illness (CI) insurance premiums in the presence of a known mutation leading to a genetic disorder, the key quantity is the penetrance, that is the probability qðxÞ that the disease has developed by age x. This function is often estimated in the genetics literature, though typically with large confidence intervals. In this paper we suggest that the main features of real penetrance functions can be represented reasonably well by simple one-parameter families of functions, which…

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