Highly Ordered Platinum‐Nanotubule Arrays for Amperometric Glucose Sensing

Abstract

Direct glucose sensing on highly ordered platinum‐nanotubule array electrodes (NTAEs) is systematically investigated. The NTAEs are fabricated by electrochemical deposition of platinum in a 3‐aminopropyltrimethoxysilane‐modified anodic alumina membrane. Their structures and morphologies are then characterized using X‐ray diffraction and scanning electron microscopy, respectively. Electrochemical results show that NTAEs with different real surface areas could be achieved by controlling the deposition time or by using anodic alumina membranes with different pore size. Electrochemical responses of the as‐synthesized NTAEs to glucose in a solutions of either 0.5 M H2SO4, or phosphate‐buffered saline (PBS, pH 7.4) containing 0.1 M KCl are discussed. Based on the different electrochemical reaction mechanisms of glucose and interferents such as p‐acetamedophenol and ascorbic acid, their high roughness factor makes NTAEs sensitive, selective, and stable enough to be a kind of biosensor for the non‐enzymatic detection of glucose. Such a glucose sensor allows the determination of glucose in the linear range 2–14 mM, with a sensitivity of 0.1 μA cm–2 mM–1 (correlation coefficient 0.999), and a detection limit of 1.0 μM glucose, with neglectable interference from physiological levels of 0.1 mM p‐acetamedophenol, 0.1 mM ascorbic acid, and 0.02 mM uric acid.

Tuning the Composition and Nanostructure of Pt/Ir Films via Anodized Aluminum Oxide Templated Atomic Layer Deposition

“…The linear response over this range is desirable, as glucose sensing is most relevant in the physiological range (3–8 m M ). This glucose sensitivity also compares well with previous results, with 0.1 μA cm −2 m M −1 reported for Pt nanotubular arrays,35 9.6 μA cm −2 m M −1 reported for mesoporous Pt,34 and 93.7 μA cm −2 m M −1 reported for nanostructured PtIr alloys 36. However, it should be noted that direct comparisons of sensitivity are difficult due to experimental variations, including solution stirring and R f .…”

Nonenzymatic Amperometric Glucose Sensing of Platinum, Copper Sulfide, and Tin Oxide Nanoparticle-Carbon Nanotube Hybrid Nanostructures

“…The CV curve with forward and reverse scans in the range of −1.0 to +1.0 V, is also shown in the Supporting Information, Figure S5. The CV curve feature is in good agreement with the previous findings of other research groups. ,, …”

“…The nonenzymatic detection limit (280 µA cm -2 mM -1 ) of the Pt-DWCNT-based GC electrode is higher than the highest value (31.3 µA cm -2 mM -1 ) reported for a nonenzymatic Pt nanotube array electrode at pH ) 9.18. 15 The sensitivity sequence is Pt > Cu 2 S > SnO 2 for both the DWCNTs and MWCNTs, which is consistent with that of the Fe(CN) 6 3-/Fe(CN) 6 4redox reaction. Figure 6a presents the selectivity testing results of the Pt-DWCNT modified electrode with successive additions of 5 µM ∼ 50 µM glucose, AA, UA, and fructose in 10 mM PBS solution at +0.5 V. Figure 6b displays the response of the Cu 2 S-DWCNT modified electrode upon the additions of glucose, UA, AA, and fructose.…”

One-Step Electrochemical Synthesis of PtNi Nanoparticle-Graphene Nanocomposites for Nonenzymatic Amperometric Glucose Detection

“…In the negative scan, the oxidation of glucose is suppressed in the high potential range due to the oxidation of PtNi NPs surfaces. The reduction of surface Pt oxide liberates more surface-active sites for the oxidation of glucose again, resulting in large and broad anodic peaks in the potential range from 0.0 to −0.5 V. These results are in line with the well-accepted mechanism of glucose oxidation on a Pt electrode in neutral media. − …”