Highly invasive alien plant Reynoutria japonica Houtt. represents a novel source for pharmaceutical industry - evidence from phenolic profile and biological activity

Abstract

Reynoutria japonica is on the IUCN list of the Worlds?100 worst invasive species, but it is also, especially its rhizome, an integral part of traditional chinese medicine. The objective of this study was to determine the amount of selected phenolic compounds in rhizome, stems, leaves and inflorescence methanol extracts of this plant, their antioxidant and anticholinesterase activity. The chemical profile of the examined extracts was obtained by a high-performance liquid chromatography. In vitro assays on DPPH, OH and NO radicals were used to estimate antioxidant potential and Ellman?s method was applied for the determination of anticholinesterase activity. Leaves and rhizome extracts were found to be rich in rosmarinic and chlorogenic acid, and selected flavonoids. Resveratrol was exclusively present in rhizome and stems extracts. All the investigated extracts expressed certain antioxidant activity, where leaves extract was the most active. However, rhizome extract was the strongest inhibitor of acetylcholinesterase. These findings indicate that there is a possibility of R. japonica exploitation for the isolation of biologically active phenolic compounds used in pharmaceutical and food industry.

Identification of Potential Glucosyltransferase Inhibitors from Cinnamic Acid Derivatives Using Molecular Docking Analysis: A Bioinformatics Study

“…Many other beneficial properties have also been reported for RA including antinociceptive and neuroprotective effects. RA is found in a wide range of medicinal plant species including Rosmarinus officinalis L. (Lamiaceae), Apiaceae, Araliaceae, Cucurbitaceae, Rubiaceae, Plantaginaceae, and Polygonaceae (39)(40)(41)(42)(43)(44).…”

Importance of Protocol Design for Suitable Green In Situ Synthesis of ZnO on Cotton Using Aqueous Extract of Japanese Knotweed Leaves as Reducing Agent

“…In a literature review, we found that a Japanese knotweed extract exhibit high values of phenolic compounds [24][25][26]47], and hence, a DPPH analysis was performed to examine the antioxidant activity of our samples (Table 2). The analysis was performed on the liquid Japanese knotweed leaves extract, and the results showed very high antioxidant activity (81.36%).…”

Screening and Evaluation of Dermo-Cosmetic Activities of the Invasive Plant Species Polygonum cuspidatum

“…It can also serve as a phytoremediator of heavy metals [ 19 ]. This plant presents many activities such as antioxidant [ 20 , 21 , 22 ], antiglycoxidative [ 23 ], anti-tyrosinase [ 24 , 25 , 26 , 27 ], antimycobacterial, antimicrobial, antidiabetic, anti-inflammatory, anticancer [ 18 , 28 , 29 , 30 ], gastroprotective [ 31 ], anti-cholinesterase [ 32 ] and gingival wound healing [ 33 ]. More recently, a study has demonstrated the effectiveness and safety of the plant for acute Respiratory Tract Infections (RTIs) in adults and children [ 34 ], and it can also fight the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [ 35 ].…”

“…Different enzymatic mechanisms are then involved depending on the enzyme considered. Several types of knotweed extracts obtained with various extraction methods or isolated compounds can act as antioxidant agents [ 21 , 25 , 29 , 32 , 38 , 39 , 40 , 41 , 42 , 43 ] or skin whiteners [ 24 , 25 , 26 , 44 , 45 , 46 , 47 ] and can facilitate treatments for skin diseases [ 27 , 48 , 49 , 50 ]. Moreover, resveratrol is now an active ingredient broadly used in cosmetology and dermatology [ 51 , 52 , 53 ].…”