2019
DOI: 10.1002/ijc.32207
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Abstract: The P2X7 receptor, an ATP‐gated ion channel, is critical for cancer cell growth, invasiveness, and angiogenesis. Previous studies indicate that P2X7 regulates osteoblast proliferation and osteodeposition and that high P2X7 expression has a pro‐growth effect in osteosarcoma. However, how it functions in osteosarcoma cell growth and metastasis is not clear. Thus, we elucidated molecular mechanisms of P2X7‐dependent positive regulation of osteosarcoma cell proliferation, invasion, migration, epithelial to mesench… Show more

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Cited by 111 publications
(141 citation statements)
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“…[51][52][53][54] Other research has shown that both constitutive and IL-6-inducible activation of STAT3 (Tyr705) and JAK2 can occur in osteosarcoma. 55 In agreement with the opinion of Peng et al, 27 Figure 7 shows that the overexpression of STAT3 offset the cinobufagin-induced reduction in CD133-positive cell ratios and the dimension of spheroids as well as the cinobufagin-induced increase in the expression of Bax, caspase-3, cleaved PARP, vimentin and α-SMA, and the lower levels of Bcl-2 and E-cad. Our studies in nude mice further confirmed the effect of cinobufagin in vivo:the reduced tumore volume( Figure 8A and B), the increased apoptotic ratio( Figure 8C and D), the CD133 flurescent expression ( Figure 8E and F), the downregulated immunohistochemistry levels of OPN, Nanog, Sox-2, Oct3/4, and p-STAT3 ( Figure 8G).…”
Section: Discussionsupporting
confidence: 88%
“…[51][52][53][54] Other research has shown that both constitutive and IL-6-inducible activation of STAT3 (Tyr705) and JAK2 can occur in osteosarcoma. 55 In agreement with the opinion of Peng et al, 27 Figure 7 shows that the overexpression of STAT3 offset the cinobufagin-induced reduction in CD133-positive cell ratios and the dimension of spheroids as well as the cinobufagin-induced increase in the expression of Bax, caspase-3, cleaved PARP, vimentin and α-SMA, and the lower levels of Bcl-2 and E-cad. Our studies in nude mice further confirmed the effect of cinobufagin in vivo:the reduced tumore volume( Figure 8A and B), the increased apoptotic ratio( Figure 8C and D), the CD133 flurescent expression ( Figure 8E and F), the downregulated immunohistochemistry levels of OPN, Nanog, Sox-2, Oct3/4, and p-STAT3 ( Figure 8G).…”
Section: Discussionsupporting
confidence: 88%
“…Numerous studies have reported that the PI3K/AKT/ GSK3β/β-catenin pathway is aberrant and promotes proliferation, migration and invasion in a wide variety of cancers [38][39][40][41][42]. In this study, we found that the upregulation of AGK enhances the phosphorylation of multiple proteins, such as p-PI3K, p-AKT and p-GSK3β, in RCC.…”
Section: Discussionsupporting
confidence: 54%
“…In our study, we found knockdown of LOXL1-AS1 dramatically inhibited osteosarcoma cell proliferation, migration, and invasion through suppressing PI3K-AKT pathway. Besides, PI3K/AKT activation has been suggested to involve in the stemness maintenance in human cancers [25][26][27]. Therefore, we will try to explore the effect of LOXL1-AS1 on the stemness maintenance in osteosarcoma for overcoming the drug resistance and relapse [28].…”
Section: Discussionmentioning
confidence: 99%