Highly efficient isotope separation and ion implantation of  163Ho for the ECHo project

Kieck, T.; Dorrer, Holger; Düllmann, Ch. E.; Gadelshin, Vadim; Schneider, F.; Wendt, Κ.

doi:10.1016/j.nima.2019.162602

Cited by 27 publications

(21 citation statements)

References 27 publications

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“…139 La 16 O, 155 Gd) or radioactive ( 155 Eu) impurities [11]. Similar conditions were observed for the shorter-lived isotope 149 Tb, also produced at ISOLDE, where isobaric contaminants 149 Eu and 133 Ce 16 O are limiting the sample purity [12]. Furthermore, the separation technique was developed to extract minute quantities of radioisotopes.…”

Section: Introductionmentioning

confidence: 71%

“…For instance, it was demonstrated that 139 Ce 16 O was present during the extraction of 155 Tb, produced at ISOLDE by irradiation of a tantalum target with high energy proton beam. 139 Ce 16 O is a thermally ionized isobaric contaminant and is not separated from 155 Tb in the electromagnet. The same concern exists for other stable (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…This technique utilises multiple lasers precisely tuned to transitions between atomic energy levels to stepwise excite and ionize isotopes of the element of interest [15]. Subsequently, the element-selective ionization process reduces the impact of any isobaric contaminants, assisting to achieve a high specific activity [16]. Efficiencies in the tens of percent range are commonly achieved with the laser ion source so that, when applicable, this is an effective means of maximising the overall radioisotope yield [17].…”

Section: Introductionmentioning

confidence: 99%

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First laser ions at the CERN-MEDICIS facility

et al. 2020

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The CERN-MEDICIS facility aims to produce emerging medical radionuclides for the theranostics approach in nuclear medicine with mass separation of ion beams. To enhance the radioisotope yield and purity of collected samples, the resonance ionization laser ion source MELISSA was constructed, and provided the first laser ions at the facility in 2019. Several operational tests were accomplished to investigate its performance in preparation for the upcoming production of terbium radioisotopes, which are of particular interest for medical applications.

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Section: Introductionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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First laser ions at the CERN-MEDICIS facility

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“…The activities produced were sufficient to perform one preliminary in vitro assay. Previously, ionization efficiency values in the order of 20–50% (on mass separators equipped with laser ion sources) were reported for holmium, dysprosium and lutetium ( 38 , 43 , 44 ). Similar results were also obtained at the CERN-MEDICIS facility for 167 Tm ( 45 ), indicating room for separation efficiency improvements for 169 Er.…”

Section: Introductionmentioning

confidence: 99%

Production of Mass-Separated Erbium-169 Towards the First Preclinical in vitro Investigations

et al. 2021

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The β−-particle-emitting erbium-169 is a potential radionuclide toward therapy of metastasized cancer diseases. It can be produced in nuclear research reactors, irradiating isotopically-enriched 168Er2O3. This path, however, is not suitable for receptor-targeted radionuclide therapy, where high specific molar activities are required. In this study, an electromagnetic isotope separation technique was applied after neutron irradiation to boost the specific activity by separating 169Er from 168Er targets. The separation efficiency increased up to 0.5% using resonant laser ionization. A subsequent chemical purification process was developed as well as activity standardization of the radionuclidically pure 169Er. The quality of the 169Er product permitted radiolabeling and pre-clinical studies. A preliminary in vitro experiment was accomplished, using a 169Er-PSMA-617, to show the potential of 169Er to reduce tumor cell viability.

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“…A mass separation step is added in between to assure high purity of the 163 Ho and remove unwanted ionized species. This approach is used in ECHo and is also foreseen for HOLMES with some differences in the technological realization and, in particular, in the ion source [16,17].…”

Section: Introductionmentioning

confidence: 99%

Specific Heat of Holmium in Gold and Silver at Low Temperatures

et al. 2020

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The specific heat of dilute alloys of holmium in gold and in silver plays a major role in the optimization of low temperature microcalorimeters with enclosed $$^{163}{{\text {Ho}}}$$ 163 Ho , such as the ones developed for the neutrino mass experiment ECHo. We investigate alloys with atomic concentrations of $$x_{{{\text {Ho}}}}=0.01{-}4\%$$ x Ho = 0.01 - 4 % at temperatures between 10 and $$800\,{{{\hbox {mK}}}}$$ 800 mK . Due to the large total angular momentum $$J=8$$ J = 8 and nuclear spin $$I=7/2$$ I = 7 / 2 of $${{\text {Ho}}}^{3+}$$ Ho 3 + ions, the specific heat of Au:Ho and Ag:Ho depends on the detailed interplay of various interactions, including contributions from the localized 4f electrons and nuclear contributions via hyperfine splitting. This makes it difficult to accurately determine the specific heat of these materials numerically. Instead, we measure their specific heat by using three experimental setups optimized for different concentration and temperature ranges. The results from measurements on six holmium alloys demonstrate that the specific heat of these materials is dominated by a large Schottky anomaly with its maximum at $$T\approx 250\,{{{\hbox {mK}}}}$$ T ≈ 250 mK , which we attribute to hyperfine splitting and crystal field interactions. RKKY and dipole–dipole interactions between the holmium atoms cause additional, concentration-dependent effects. With regard to ECHo, we conclude that for typical operating temperatures of $$T\le 20\,{{{\hbox {mK}}}}$$ T ≤ 20 mK , silver holmium alloys with $$x_{{{\text {Ho}}}}\gtrsim 1\%$$ x Ho ≳ 1 % are suited best.

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Highly efficient isotope separation and ion implantation of 163Ho for the ECHo project

Cited by 27 publications

References 27 publications

First laser ions at the CERN-MEDICIS facility

First laser ions at the CERN-MEDICIS facility

Production of Mass-Separated Erbium-169 Towards the First Preclinical in vitro Investigations

Specific Heat of Holmium in Gold and Silver at Low Temperatures

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