Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for <i>in Vivo</i> Photodynamic Therapy of Cancer

Cheng, Yu; Samia, Anna Cristina S.; Meyers, Joseph; Panagopoulos, Irene.; Fei, Baowei; Burda, Clemens

doi:10.1021/ja801631c

Cited by 673 publications

(563 citation statements)

References 37 publications

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“…Their colloidal properties and, ultimately, their biodistribution can be modulated through varying the copolymer composition and they exhibit prolonged blood circulation [119]. PEGylated gold nanoparticles phthalocyanine conjugates were shown to exhibit significantly shortened uptake times [120]. Even simple PEGylation of the core photosensitizer itself results in high cellular uptake and low aggregation in biological media [121].…”

Section: Biodegradable Nanoparticlesmentioning

confidence: 99%

Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

319

210

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SummaryPhotodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for the treatment of various diseases such as cancer and macular degeneration. It is a two-step technique in which delivery of a photosensitizing drug is followed by irradiation of light. Activated photosensitizers transfer energy to molecular oxygen which results in generation of reactive oxygen species which in turn cause cells apoptosis or necrosis. Although this modality has significantly improved quality of life and survival time for many cancer patients it still offers significant potential for further improvement. In addition to the development of new PDT drugs, the use of nanosized carriers for photosensitizers is a promising approach which might improve the efficiency of photodynamic activity and which can overcome many side effects associated with classic photodynamic therapy. This review aims at highlighting the different types of nanomedical approaches currently used in PDT and outlines future trends and limitations of nanodelivery of photosensitizers. PDT -photodynamic therapy; PGA -poly(glycolic acid); PGLA -poly(D,L-lactide-coglycolide); PLA -poly(lactic acid); PS -photosensitizer; PEG -polyethylene glycol; ALA  aminolevulinic acid; m-THPC  5,10,15,20-tetra-(m-hydroxyphenyl)chlorine; m-THPP  meso-tetra(p-hydroxyphenyl); PpIX  protoporphyrin; Hp  hematoporphyrin; Pc4  silicon phthalocyanine; Ig  immunoglobulin; Tf  transferrin; TfR  transferrin receptor; VEGF  vascular endothelial growth factor; EPR  enhanced permeability and retention effect; FRET  fluorescence resonance energy transfer; MRI  magnetic resonance imaging; RES  reticuloendothelial system; ROS  reactive oxygen species; NP  nanoparticle; ND -nanodiamonds; SNP  silica nanoparticle; AMD  age-related macular degeneration; CNV  choroidal neovascularization; PTT  photothermal therapy;

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Section: Biodegradable Nanoparticlesmentioning

confidence: 99%

Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

319

210

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“…Their potential use in the field ranges from detection by imaging, labeling, or sensing [1][2][3][4][5] to treatment, including drug delivery and phototherapy [6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles induce nuclear damage in breast cancer cells, which is further amplified by hyperthermia

Kodiha

Hutter

Boridy

et al. 2014

Cell. Mol. Life Sci.

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nanospheres, damaged the nucleus at normal growth temperature, several of these defects were further exacerbated by mild hyperthermia. Taken together, the toxicity of gold nanoparticles correlated with changes in nuclear organization and function. These results emphasize that the cell nucleus is a prominent target for gold nanoparticles of different morphologies. Moreover, we demonstrated that RNA synthesis in nucleoli provides quantitative information on nuclear damage and cancer cell survival.

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“…Size (diameter) and refractive index are crucial to many gold nanoparticle related applications, such as surface-enhanced Raman scattering (SERS), 1,2 advanced spectroscopy, 3 chemical sensing, 4 biomedical imaging, 5 drug delivery 6 and clinical diagnosis. 7 Gold nanoparticles can also be used as on-chip assays for protein detection and DNA biomarker selection, which highly depends on the diameter and refractive index of gold nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Determination of size and refractive index of single gold nanoparticles using an optofluidic chip

et al. 2017

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We report a real-time method to determine the size, i.e. diameter, and refractive index of single gold nanoparticles using an optofluidic chip, which consists of a quasi-Bessel beam optical chromatography. The tightly focused (∼ 0.5 μm) quasi-Bessel beam with low divergence (NA ∼ 0.04) was used to trap sub-100 nm gold nanoparticles within a long trapping distance of 140 μm. In the experiment, 60 to 100 nm gold nanoparticles were separated efficiently with at least 18 μm. The diameter and refractive index (real and imaginary) of single gold nanoparticles were measured at high resolutions with respect to the trapping distance, i.e. 0.36 nm/μm, 0.003/μm and 0.0016/μm, respectively.

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Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer

Cited by 673 publications

References 37 publications

Nanodrug applications in photodynamic therapy

Nanodrug applications in photodynamic therapy

Gold nanoparticles induce nuclear damage in breast cancer cells, which is further amplified by hyperthermia

Determination of size and refractive index of single gold nanoparticles using an optofluidic chip

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