Higher SaO2 in chronic neonatal lung disease: Does it improve sleep?

Effect of Supplemental Oxygen on Sleep Architecture and Cardiorespiratory Events in Preterm Infants

“…The use of SupOx in preterm infants was associated with an increase in QS with a reciprocal decrease in AS. Our findings concur with those of Fitzgerald et al, 6 who showed that elevation of inspired oxygen concentrations in infants with CNLD resulted in a trend toward higher percentage of slow-wave sleep and decreased AS. These authors further speculated that an increased percentage of slow-wave sleep may contribute to improved growth in CNLD infants who maintained higher oxygenation; the latter coincides with normalization of growth hormone urinary excretion.…”

“…The SupOx flow rate was set at 0.25 L/min, based on previous studies on the effect of SupOx on sleep in chronic neonatal lung diseases. 5,6 This flow delivered a fraction of inspired oxygen (Fio 2 ) of approximately 35% to 45% in infants who weighed between 2.2 and 2.6 kg. 7 Studies were considered acceptable only when both portions included at least 4 hours of valid recordings, because it has been previously shown that the reliability of apnea estimation is adequate only when study duration exceeds 3 hours.…”

Home oxygen therapy after preterm birth in Western Australia

“…The sleep study is an integral part or our home oxygen programme. The decision regarding discontinuing supplemental O 2 at night is based upon observations that a total of 20 min <92% is associated with slower weight gain 10 , but that SaO 2 > 93% is adequate for optimum sleep 25 . The interval between the daytime discontinuation and the final sleep study, was 2−4 weeks.…”

Assessment of Current Strategies for Weaning Premature Infants From Supplemental Oxygen in the Outpatient Setting

“…However, other studies have indicated that hypoxia is most likely to occur during feeding and sleeping, which suggests that nighttime saturations are an important factor to be considered. 35 The majority of respondents identified 125 mL/min as the flow rate from which they would wean to before initiating room air challenges, but the only study to look at this question indicated that infants are most likely to wean successfully if they require oxygen flow rates of 20 mL/kg/min or less. 34 The BTS guidelines recommend 100mL/min as a flow rate from which to discontinue oxygen therapy.…”