Higher platelet count, even within normal range, is associated with increased arterial stiffness in young and middle-aged adults

Chou, Yu-Tsung; Chen, Hung-Yu; Wu, I-Hsuan; Su, Fei-Lin; Li, Wen-Huang; Hsu, Hung-Lung; Tai, Jui-Ting; Chao, Ting‐Hsing

doi:10.18632/aging.204335

Cited by 3 publications

(3 citation statements)

References 61 publications

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“…Although aspirin has been comprehensively used in populations, comparatively, its clinical reports about arterial stiffness are not too many [ 19 , 61 , 62 ], and none of them involve mechanism explanation. It is taken for granted anti-platelet effect duo to direct correlation of platelet activation with arterial stiffness [ 63 , 64 , 65 ]. Recently, several studies propose that the effect of aspirin on improving arterial stiffness is independent of anti-platelet.…”

Section: Discussionmentioning

confidence: 99%

Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats

et al. 2023

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Hypertension in adolescents is associated with adverse cardiac and vascular events. In addition to lowering blood pressure, it is not clear whether pharmacological therapy in early life can improve vascular remodeling. This study aimed to evaluate the effects of long-term administration of losartan, aspirin, and atorvastatin on vascular remodeling in juvenile spontaneously hypertensive rats (SHRs). Losartan, aspirin, and atorvastatin were administered via gavage at doses of 20, 10, and 10 mg/kg/day, respectively, on SHRs aged 6–22 weeks. Paraffin sections of the blood vessels were stained with hematoxylin-eosin (H&E) and Sirius Red to evaluate the changes in the vascular structure and the accumulation of different types of collagen. The plasma levels of renin, angiotensin II (Ang II), aldosterone (ALD), endothelin-1 (ET-1), interleukin-6 (IL-6), and neutrophil elastase (NE) were determined using ELISA kits. After the 16-week treatment with losartan, aspirin, and atorvastatin, the wall thickness of the thoracic aorta and carotid artery decreased. The integrity of the elastic fibers in the tunica media was maintained in an orderly manner, and collagen deposition in the adventitia was retarded. The plasma levels of renin, ALD, ET-1, IL-6, and NE in the SHRs also decreased. These findings suggest that losartan, aspirin, and atorvastatin could improve vascular remodeling beyond their antihypertensive, anti-inflammatory, and lipid-lowering effects. Many aspects of the protection provided by pharmacological therapy are important for the prevention of cardiovascular diseases in adults and older adults.

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Section: Discussionmentioning

confidence: 99%

Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats

et al. 2023

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“…Studies associate platelet count and mean platelet volume with tumor metastasis ( 12 , 13 ). Additionally, within the normal range, elevated platelet count correlates with increased arterial stiffness in young and middle-aged individuals ( 14 ). A retrospective analysis of 2056 intensive care units (ICU) patients associate thrombocytopenia with acute respiratory distress syndrome and death ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Nonlinear relationship between platelet count and 30-day in-hospital mortality in intensive care unit stroke patients: a multicenter retrospective cohort study

Wang,

Liu,

Zhou

et al. 2024

Front. Neurol.

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BackgroundEvidence of the relationship between platelet count and 30-day in-hospital mortality in ICU stroke patients is still scarce. Therefore, the purpose of this study was to explore the relationship between platelet count and 30-day in-hospital mortality among ICU stroke patients.MethodsWe conducted a multicenter retrospective cohort study using data from 8,029 ICU stroke patients in the US eICU-CRD v2.0 database from 2014 to 2015. Utilizing binary logistic regression, smooth curve fitting, and subgroup analyses, we examined the link between platelet count and 30-day in-hospital mortality.ResultsThe 30-day in-hospital mortality prevalence was 14.02%, and the mean platelet count of 223 × 109/L. Adjusting for covariates, our findings revealed an inverse association between platelet count and 30-day in-hospital mortality (OR = 0.975, 95% CI: 0.966, 0.984). Subgroup analyses supported the robustness of these results. Moreover, a nonlinear relationship was observed between platelet count and 30-day in-hospital mortality, with the inflection point at 163 × 109/L. On the left side of the inflection point, the effect size (OR) was 0.92 (0.89, 0.95), while on the right side, the relationship was not statistically significant.ConclusionThis study establishes an independent negative association between platelet count and 30-day in-hospital mortality in ICU stroke patients. Furthermore, a nonlinear relationship with a saturation effect was identified, suggesting that maintaining the platelet count around 163 × 109/L can reduce 30-day in-hospital mortality in these patients.

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“…Studies associate platelet count and mean platelet volume with tumor metastasis (12,13). Additionally, within the normal range, elevated platelet count correlates with increased arterial stiffness in young and middle-aged individuals (14). A retrospective analysis of 2056 intensive care units (ICU) patients associate thrombocytopenia with acute respiratory distress syndrome and death (15).…”

Section: Introductionmentioning

confidence: 99%

Nonlinear relationship between platelet count and 30-day in-hospital mortality in ICU stroke patients: a multicenter retrospective cohort study

Wang,

Liu,

Zhou

et al. 2024

Preprint

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Background: Evidence of the relationship between platelet count and 30-day in-hospital mortality in ICU stroke patients is still scarce. Therefore, the purpose of this study was to explore the relationship between platelet count and 30-day in-hospital mortality among ICU stroke patients. Methods: We conducted a multicenter retrospective cohort study using data from 8029 ICU stroke patients in the US eICU-CRD v2.0 database from 2014 to 2015. Utilizing binary logistic regression, smooth curve fitting, and subgroup analyses, we examined the link between platelet count and 30-day in-hospital mortality. Results: The 30-day in-hospital mortality prevalence was 14.02%, and the mean platelet count of 223×109/L. Adjusting for covariates, our findings revealed an inverse association between platelet count and 30-day in-hospital mortality (OR = 0.975, 95% CI: 0.966, 0.984). Subgroup analyses supported the robustness of these results. Moreover, a nonlinear relationship was observed between platelet count and 30-day in-hospital mortality, with the inflection point at 163×109/L. On the left side of the inflection point, the effect size (OR) was 0.92 (0.89, 0.95), while on the right side, the relationship was not statistically significant. Conclusion: This study establishes an independent negative association between platelet count and 30-day in-hospital mortality in ICU stroke patients. Furthermore, a nonlinear relationship with a saturation effect was identified, suggesting that maintaining the platelet count around 163×109/L can reduce 30-day in-hospital mortality in these patients.

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Higher platelet count, even within normal range, is associated with increased arterial stiffness in young and middle-aged adults

Cited by 3 publications

References 61 publications

Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats

Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats

Nonlinear relationship between platelet count and 30-day in-hospital mortality in intensive care unit stroke patients: a multicenter retrospective cohort study

Nonlinear relationship between platelet count and 30-day in-hospital mortality in ICU stroke patients: a multicenter retrospective cohort study

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