Higher parity and shorter breastfeeding duration

Shinde, Shivani; Forman, Michéle R.; Kuerer, Henry Mark; Yan, Kai; Peintinger, Florentia; Hunt, Kelly K.; Hortobágyi, Gabriel N.; Pusztai, Lajos; Symmans, W. Fraser

doi:10.1002/cncr.25443

Cited by 89 publications

(47 citation statements)

References 36 publications

(55 reference statements)

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“…This is important because studies in Western populations have demonstrated that breast cancer is highly heterogeneous and risk factors may differ between different breast cancer subtypes [19–21, 29, 30]. This study is also likely underpowered to draw conclusions about whether OCP use and HRT use are breast cancer risk factors in Vietnamese women, because the use of OCP and HRT in Vietnam has traditionally been much lower than in Western populations.…”

Section: Discussionmentioning

confidence: 99%

A Matched Case-Control Study of Risk Factors for Breast Cancer Risk in Vietnam

Nguyen

Duong

et al. 2016

International Journal of Breast Cancer

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Background. Vietnam has a low age-standardized incidence of breast cancer, but the incidence is rising rapidly with economic development. We report data from a matched case-control study of risk factors for breast cancer in the largest cancer hospital in Vietnam. Methods. 492 incident breast cancer cases unselected for family history or age at diagnosis and 1306 control women age 25–75 were recruited from the National Cancer Hospital (BVK), Hanoi. Structured interviews were conducted and pathology data was centrally reported at the National Cancer Hospital of Vietnam, in Hanoi. Results. Our analysis included 294 matched pairs. Mean age at diagnosis was 46.7 years. Lower mean parity, older age at first parity, increasing weight and BMI at age 18, and increasing BMI at diagnosis were positively correlated with breast cancer cases compared to controls. Age at first menarche and duration of breastfeeding were not statistically different between cases and controls. Conclusions. In this study we demonstrate that breast cancer in Vietnam is associated with some but not all of the published risk factors from Western populations. Our data is consistent with other studies of breast cancer in Asian populations.

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Section: Discussionmentioning

confidence: 99%

A Matched Case-Control Study of Risk Factors for Breast Cancer Risk in Vietnam

Nguyen

Duong

et al. 2016

International Journal of Breast Cancer

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“…39 Development of TNBC in the absence or short duration of breastfeeding might be caused by progenitor cells in breast tissue not undergoing terminal differentiation and apoptosis that usually occurs with prolonged lactation, resulting in a persistent pool of progenitor cells that are at risk for carcinogenesis. 40 …”

Section: Epidemiological Risk Factorsmentioning

confidence: 99%

Epidemiology, biology, and treatment of triple-negative breast cancer in women of African ancestry

Brewster

Chávez-MacGregor

Brown

2014

The Lancet Oncology

191

156

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Breast cancer incidence is increasing worldwide, and breast cancer-related mortality is highest in women of African ancestry, who are more likely to have basal-like or triple-negative breast cancer (TNBC) than are women of European ancestry. Identification of cultural, epidemiological, and genetic risk factors that predispose women of African ancestry to TNBC is an active area of research. Despite the aggressive behaviour of TNBC, achievement of a pathological complete response with chemotherapy is associated with good long-term survival outcomes, and sensitivity to chemotherapy does not seem to differ according to ethnic origin. Discovery of the molecular signalling molecules that define TNBC heterogeneity has led to the development of targeted agents such as inhibitors of poly (ADP-ribose) polymerase-1 and mTOR and immunomodulatory drugs that are in the early stages of clinical testing. First, we summarise the existing published work on the differences reported on the epidemiology, biology, and response to systemic treatment of TNBC between women of African ancestry and white women, and identify some gaps in knowledge. Second, we review the opportunities for development of new therapeutic agents in view of the potential high clinical relevance for patients with TNBC irrespective of race or ethnic origin.

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“…For example, absent or short duration of breastfeeding has been consistently associated with a higher risk of triple-negative non-IBC compared with the luminal A or ER+ defined subtypes of non-IBC (12,13, 16). Since the triple-negative subtype is overrepresented among IBC compared to non-IBC (7), identifying the risk factors for this aggressive tumor subtype and others is relevant for investigating biological mechanisms underlying the etiology of IBC and for developing strategies for subtype-specific breast cancer prevention (1,17).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological risk factors associated with inflammatory breast cancer subtypes

Atkinson

El‐Zein

Valero

et al. 2016

Cancer Causes Control

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Background In this single-institution case-control study, we identified risk factors associated with inflammatory breast cancer (IBC) subtypes based on staining of (estrogen receptor [ER], progesterone receptor [PR]) and expression of human epidermal growth factor 2 (HER2neu) to determine distinct etiologic pathways. Methods We identified 224 women with IBC and 396 cancer-free women seen at the MD Anderson Cancer Center. Multinomial logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between breast cancer risk factors and the IBC tumor subtypes: luminal (ER+ and/or PR+/Her2neu−), Her2neu+ (any ER and PR, Her2neu+), and triple-negative (ER−/PR−/Her2neu−). Results In multivariable analysis, compared with women age ≥ 26 at first pregnancy, women age <26 had a higher risk of triple-negative IBC (OR 3.32, 95% CI 1.37–8.05). Women with a history of breastfeeding had a lower risk of triple-negative (OR 0.30; 95% CI: 0.15–0.62) and luminal IBC (OR 0.35, 95% CI 0.18–0.68). A history of smoking was associated with an increased risk of luminal IBC (OR 2.37; 95% CI 1.24–4.52). Compared with normal-weight women, those who were overweight or obese (body mass index ≥25 kg/m2) had a higher risk of all three tumor subtypes (P<0.01 for all subtypes). Conclusion Overweight or obese status are important modifiable risk factors for IBC of any subtype. Modifiable risk factors, age at first pregnancy (≥26), breastfeeding and smoking may be associated with specific IBC subtypes. These results highlight the importance of evaluating epidemiologic risk factors for IBC for the identification of subtype-specific prevention strategies.

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Higher parity and shorter breastfeeding duration

Cited by 89 publications

References 36 publications

A Matched Case-Control Study of Risk Factors for Breast Cancer Risk in Vietnam

A Matched Case-Control Study of Risk Factors for Breast Cancer Risk in Vietnam

Epidemiology, biology, and treatment of triple-negative breast cancer in women of African ancestry

Epidemiological risk factors associated with inflammatory breast cancer subtypes

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