Higher intraocular pressure is associated with leukoaraiosis among middle-aged and elderly Koreans without glaucoma or dementia

Park, Byoungjin; Jk, Kim; Lee, Yong-Jae

doi:10.1038/eye.2014.63

Cited by 1 publication

(2 citation statements)

References 27 publications

(26 reference statements)

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“…This finding is in keeping with the observations of Park et al . 12 who recently demonstrated that high values of IOP were positively associated with the presence of deep white matter hyper intensities in middle-aged and elderly subjects without glaucoma. Other than this, to our knowledge, this is the first demonstration of a significant association between POAG and cerebral small vessel disease.…”

Section: Discussionmentioning

confidence: 99%

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Primary Open Angle Glaucoma is Associated with MR Biomarkers of Cerebral Small Vessel Disease

Mercieca

Cain

Hansen

et al. 2016

Sci Rep

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This prospective study tests the hypotheses that: 1) glaucoma is associated with evidence of cerebral small vessel disease; 2) that imaging biomarkers of cerebral small vessel disease in POAG and NTG will show different characteristics. 12 normal controls, 7 patients with primary open angle glaucoma (POAG) and 9 patients with normal tension glaucoma (NTG) were recruited. Ophthalmological clinical assessment and MR imaging of the brain were performed. MR imaging was used to quantify white matter lesion load, frequency of dilated perivascular spaces (PVS) and abnormalities in cerebral hydrodynamics. Patients with POAG had significantly greater white matter lesion load (p < 0.05), more PVS in the centrum semiovale (p < 0.05) and had higher overall PVS scores than controls (p < 0.05). In the POAG group, optic cup-to-disc ratio (CDR) was positively correlated with deep white matter hyperintensities (R2 = 0.928, p < 0.01). Mean deviation on the Humphrey visual field assessment was negatively correlated with deep white matter lesion load (R2 = −0.840, p < 0.01), total white matter lesion load (R2 = −0.928, p < 0.01) and total PVS (R2 = −0.820, p < 0.01). MR evidence of cerebral small vessel disease is strongly associated with a diagnosis of POAG and with the severity of abnormalities in CDR and visual field.

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Section: Discussionmentioning

confidence: 99%

“…A previous study by Stroman et al . found larger numbers of white-matter lesions in patients with NTG than controls 11 and a recent study demonstrated that intraocular pressure was higher in normal individuals with evidence of cerebral white-matter lesions 12 .…”

mentioning

confidence: 94%