High toughness resorbable brushite-gypsum fiber-reinforced cements

Moussa, Hanan; hadad, Amir A. El; Sarrigiannidis, Stylianos; Saad, Ahmed; Wang, Min; Taqi, Doaa; Al-Hamed, Faez Saleh; Salmerón‐Sánchez, Manuel; Cerruti, Marta; Tamimi, Faleh

doi:10.1016/j.msec.2021.112205

Cited by 7 publications

(5 citation statements)

References 62 publications

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“…Gypsum cements are an important functional material, which are widely used in biomedical bone repair and in architecture. − As such, the regulation effects of chiral amino acids on gypsum cements were also explored. The formation of gypsum cements is a typical phase transformation process from the raw material, α-calcium sulfate hemihydrate (CaSO 4 · 1/2H 2 O, CSH), to gypsum, where CSH powder is first dissolved in water, followed by gypsum crystal precipitation. , It was found that this phase transformation was influenced by the chirality of amino acid additives interacting with dynamic gypsum crystals (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…Gypsum (CaSO 4 ·2H 2 O, monoclinic space group C2/c ), which can interact with amino acids, has been implicated in the origin of biochemical homochirality. , Large marine sulfate evaporate deposits formed during the Paleoproterozoic Great Oxidation Event; among them, gypsum is almost entirely a primary mineral phase and remained in a dynamic growing state throughout the early stages of life. , Furthermore, the presence of gypsum has even been implicated as a possible biosignatures on Mars. , On a more practical note, gypsum cements are widely used as biomedical implant materials (such as dental plaster casts and bone repair materials) and building materials, where control and optimization of their mechanical performance is much sought after. − …”

Section: Introductionmentioning

confidence: 99%

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Selective Chiral Recognition between Amino Acids and Growing Gypsum Crystals

Gao,

Li,

Sun

et al. 2023

Langmuir

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In nature, selective chiral interactions between biomolecules and minerals provide insight into the mysterious origin of homochirality. Here, we show growing gypsum crystals in a nonequilibrium state can recognize chiral enantiomers of amino acids. The chiral selection for amino acids with different functional groups by growing minerals are distinct. For 11 amino acids, the D-isomer slows dynamic gypsum growth more than the L-isomer, whereas for another 7 amino acids, the opposite was observed. These differences in chiral recognition are attributed to the different stereochemical matching between the chiral amino acids and the dynamic steps of growing gypsum. These stereoselective interactions between amino acid enantiomers and dynamic growing crystals can be applied toward the fabrication of gypsum cements to regulate their structure and mechanical properties. These findings provide insight into understanding the mechanism of the origin of homochirality in nature and suggest a pathway for constructing advanced functional materials.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selective Chiral Recognition between Amino Acids and Growing Gypsum Crystals

Gao,

Li,

Sun

et al. 2023

Langmuir

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“…Moreover, following implantation, DCPD rapidly dissolves and transforms into unreactive HAP, impairing resorption (Sheikh et al, 2015). However, this issue was recently addressed by mixing DCPD with calcium sulfate dihydrate (Moussa et al, 2021). The insufficient osteoconductivity of DCDP may be improved via elemental iron doping (Pan et al, 2021).…”

Section: Microstructure and Mechanism Of Formation Of Enamel And Bonementioning

confidence: 99%

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

Saito

Onuma

Yamakoshi

2023

Genesis

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Summary The cementum is the outermost layer of hard tissue covering the dentin within the root portion of the teeth. It is the only hard tissue with a specialized structure and function that forms a part of both the teeth and periodontal tissue. As such, cementum is believed to be critical for periodontal tissue regeneration. In this review, we discuss the function and histological structure of the cementum to promote crystal engineering with a biochemical approach in cementum regenerative medicine. We review the microstructure of enamel and bone while discussing the mechanism underlying apatite crystal formation to infer the morphology of cementum apatite crystals and their complex structure with collagen fibers. Finally, the limitations of the current dental implant treatments in clinical practice are explored from the perspective of periodontal tissue regeneration. We anticipate the possibility of advancing periodontal tissue regenerative medicine via cementum regeneration using a combination of material science and biochemical methods.

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“…Gypsum, utilized widely as building materials and biomedical implant materials, occurs as biomineral within many organisms such as the exoskeletons of crustaceans and the tissues of desert shrubs. − Additionally, as a significant mineral phase found in large marine sulfate evaporate deposits, gypsum remained in a dynamic growing state during life’s early stage, which can interact with amino acids and has been implicated in the origin of biochemical homochirality. , …”

Section: Introductionmentioning

confidence: 99%

Selective Chiral Interactions between Hydrophilic/Hydrophobic Amino Acids and Growing Gypsum Crystals

Sun,

Li,

Gao

et al. 2024

Langmuir

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In nature, selective interactions between chiral amino acids and crystals are important for the formation of chiral biominerals and provide insight into the mysterious origin of homochirality. Here, we show that chiral amino acids with different hydrophilicities/ hydrophobicities exhibit different chiral selectivity preferences in the dynamically growing gypsum [001] steps. Hydrophilic amino acids show a chiral selectivity preference for their D-isomers, whereas hydrophobic amino acids prefer their L-isomers. These differences in chiral recognition can be attributed to the different stereochemical matching between the hydrophilic and hydrophobic amino acids on the [001] steps of growing gypsum. These different chiral selectivities resulting from the amino acid hydrophilicity/hydrophobicity are confirmed by the experimental crystallization investigations from nano regulation on dynamic steps, to microscopic modification of gypsum morphology, and to macroscopic precipitation. Furthermore, as the hydrophilicity of amino acids increases, the disparity in chiral selection rises; conversely, the increase in the hydrophobicity of amino acids results in a decline in chiral selection. These insights improve our understanding of the interaction mechanism between amino acids and crystals and provide insights into the formation process of chiral biominerals and the origin of homochirality in nature.

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High toughness resorbable brushite-gypsum fiber-reinforced cements

Cited by 7 publications

References 62 publications

Selective Chiral Recognition between Amino Acids and Growing Gypsum Crystals

Selective Chiral Recognition between Amino Acids and Growing Gypsum Crystals

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

Selective Chiral Interactions between Hydrophilic/Hydrophobic Amino Acids and Growing Gypsum Crystals

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