volume 113, issue 39, P11046-11051 2016
DOI: 10.1073/pnas.1612826113
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Abstract: Image-based approaches to single-cell transcriptomics, in which RNA species are identified and counted in situ via imaging, have emerged as a powerful complement to single-cell methods based on RNA sequencing of dissociated cells. These image-based approaches naturally preserve the native spatial context of RNAs within a cell and the organization of cells within tissue, which are important for addressing many biological questions. However, the throughput of these imagebased approaches is relatively low. Here …

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