High-throughput screening for integrative biomaterials design: exploring advances and new trends

Oliveira, Mariana B.; Mano, J. F.

doi:10.1016/j.tibtech.2014.09.009

Cited by 51 publications

(40 citation statements)

References 99 publications

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“…[7][8][9][10][11] Distinct HTS procedures have already been used for the production of LbL constructs based on: selective deposition, [ 12 ] microfl uidics, [ 13,14 ] disruption of hydrogen-bonded multilayers, [ 15,16 ] and photoreactive multilayers. [7][8][9][10][11] Distinct HTS procedures have already been used for the production of LbL constructs based on: selective deposition, [ 12 ] microfl uidics, [ 13,14 ] disruption of hydrogen-bonded multilayers, [ 15,16 ] and photoreactive multilayers.…”

Section: Doi: 101002/adfm201505047mentioning

confidence: 99%

High‐Throughput Topographic, Mechanical, and Biological Screening of Multilayer Films Containing Mussel‐Inspired Biopolymers

Neto

Vasconcelos

Oliveira

et al. 2016

Adv Funct Materials

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A high‐content screening method to characterize multifunctional multilayer films that combine mechanical adhesion and favorable biological response is reported. Distinct combinations of nanostructured films are produced using layer‐by‐layer methodology and their morphological, physicochemical, and biological properties are analyzed in a single microarray chip. Inspired by the composition of the adhesive proteins in mussels, thin films containing dopamine‐modified hyaluronic acid are studied. Flat biomimetic superhydrophobic patterned chips produced by a bench‐top methodology are used for the build‐up of arrays of multilayer films. The wettability contrasts imprinted onto the chips are allowed to produce individual, position controlled, multilayer films in the wettable regions. The flat configuration of the chip permits to perform a series of nondestructive measurements directly on the individual spots. In situ adhesion properties are directly measured in each spot, showing that nanostructured films richer in dopamine promote the adhesion. In vitro tests show an enhanced cell adhesion for the films with more catechol groups. The advantages presented by this platform include ability to control the uniformity and size of the multilayers films, its suitability to be used as a new low cost toolbox and for high‐content cellular screening, and capability for monitoring in situ a variety of distinct material properties.

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Section: Doi: 101002/adfm201505047mentioning

confidence: 99%

High‐Throughput Topographic, Mechanical, and Biological Screening of Multilayer Films Containing Mussel‐Inspired Biopolymers

Neto

Vasconcelos

Oliveira

et al. 2016

Adv Funct Materials

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“…23,24 Micropatterning and microfluidic systems have been used to create hydrogels with spatially controlled organization as well as numerous cellmaterial or cell-cell combinations to analyze distinct biological issues. 25,26 Micro-patterned arrays have been generated by immobilizing hydrogels on different micro-domains within a plane surface, and they have been used for disease diagnosis, prognosis, biochemical analysis, and therapeutic regimes, and have become an alternative approach for high-throughput multiplexed assays.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Hydrogel Particles of Defined Shapes Using Superhydrophobic‐Hydrophilic Micropatterns

et al. 2016

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We report a method to rapidly fabricate alginate hydrogel particles of specific sizes and shapes.Our method is based on the formation of arrays of droplets of pre-hydrogel solutions on superhydrophobic-hydrophilic patterns using the process of discontinuous dewetting, followed by their gelation via the parallel addition of CaCl 2 to the individual droplets via the sandwiching method. We demonstrate that viability of living cells incorporated within the hydrogel particles is higher during the long-term cultivation than in the case of cells cultured in the bulk threedimensional hydrogel matrix. Incorporation of magnetic particles into the free-standing hydrogel particles containing living cells enabled ease manipulation of the particles using an external magnetic field.

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“…Recently, bio-inspired surfaces with extreme wettability have been extensively used in biomedical applications because their unique wetting property provides engineered cellular microenvironments and cell-substrate interactions, which cannot be achieved using conventional cell and tissue culture platforms [14,15,16,17,18,19]. Despite this high interest of the utilization of extreme wetting surfaces in biomedical applications, only a few reports have been published to understand their prospective roles and applications in the biomedical field [20,21]. …”

Section: Introductionmentioning

confidence: 99%

Bio-Inspired Extreme Wetting Surfaces for Biomedical Applications

et al. 2016

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Biological creatures with unique surface wettability have long served as a source of inspiration for scientists and engineers. More specifically, materials exhibiting extreme wetting properties, such as superhydrophilic and superhydrophobic surfaces, have attracted considerable attention because of their potential use in various applications, such as self-cleaning fabrics, anti-fog windows, anti-corrosive coatings, drag-reduction systems, and efficient water transportation. In particular, the engineering of surface wettability by manipulating chemical properties and structure opens emerging biomedical applications ranging from high-throughput cell culture platforms to biomedical devices. This review describes design and fabrication methods for artificial extreme wetting surfaces. Next, we introduce some of the newer and emerging biomedical applications using extreme wetting surfaces. Current challenges and future prospects of the surfaces for potential biomedical applications are also addressed.

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High-throughput screening for integrative biomaterials design: exploring advances and new trends

Cited by 51 publications

References 99 publications

High‐Throughput Topographic, Mechanical, and Biological Screening of Multilayer Films Containing Mussel‐Inspired Biopolymers

High‐Throughput Topographic, Mechanical, and Biological Screening of Multilayer Films Containing Mussel‐Inspired Biopolymers

Fabrication of Hydrogel Particles of Defined Shapes Using Superhydrophobic‐Hydrophilic Micropatterns

Bio-Inspired Extreme Wetting Surfaces for Biomedical Applications

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