High sun protection factor sunscreens in the suppression of actinic neoplasia

Naylor, M. F.

doi:10.1001/archderm.131.2.170

Cited by 150 publications

(114 citation statements)

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“…The patients should wear a head-gear, long sleeves and long trousers during sunny days. Moreover, the regular use of high-SPF sunscreens significantly reduces the frequency of precancerous and neoplastic lesions in the skin [12, 13]. Therefore they must be routinely used by RTR for the whole year.…”

Section: Discussionmentioning

confidence: 99%

Sun Protection in Renal Transplant Recipients: Urgent Need for Education

Szepietowski

Reich²,

Nowicka³

et al. 2005

Dermatology

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Background: Renal transplant recipients (RTR) are considered as a high-risk group of skin cancer development. Objective: The aim of the present studywas to find out the knowledge about the harmfulness of sunlight and the methods of sun protection among RTR. Material and Methods: 151 RTR (91 males and 60 females) were surveyed using a specially designed questionnaire. Results: The knowledge about the danger of sunlight exposure among RTR appeared to be very unsatisfactory. Only 40.4% of patients knew that the development of skin cancer is connected with the exposure to sunlight. Moreover, only 68.2% of investigated individuals considered RTR as a high-risk group of skin cancer development. Although 74.8% of patients were informed about the necessity of sun protection, only 11.3% could explain what the number of the SPF (sun protection factor) means. Females significantly more often knew that RTR are especially predisposed to the development of skin cancers (p = 0.0001) and significantly more frequently could explain what the SPF number means (p = 0.006). 72.8% of RTR (females significantly more often, p = 0.02) made efforts to avoid sunlight irradiation. However, only 5.3% of the examined patients routinely used creams with SPF (females significantly more often, p < 0.0001). More than a half of the patients (62.3%) did not apply any sun protection. Conclusions: The present study revealed the urgent necessity of education concerning the harmfulness of sunlight and the methods of sun protection among RTR. Moreover, it is postulated that every patient should be routinely examined by a dermatologist in a dedicated transplant patient clinic.

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Section: Discussionmentioning

confidence: 99%

Sun Protection in Renal Transplant Recipients: Urgent Need for Education

Szepietowski

Reich²,

Nowicka³

et al. 2005

Dermatology

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“…So far, it has not been possible to study the role of sunscreens in this respect since there exist no suitable laboratory animal models that mimic melanoma development in humans. Two placebo-controlled, prospective trials have shown that continuous application of sunscreens can reducethe incidence of actinic keratoses (Naylor et al, 1995;Thompson et al, 1993). Unfortunately, these results must be interpreted cautiously since they included persons highly aware of the danger associated with unconsidered sun exposure.…”

Section: Discussionmentioning

confidence: 99%

“…In the experimental situation, use of sunscreens has been found to delay the onset of photocarcinogenesis (Kligman et al, 1980;Wulf et al, 1982) and to inhibit mutation of the p53 gene in keratinocytes (Ananthaswamy et al, 1997) and the incidence of actinic keratoses in humans (Naylor et al, 1995;Thompson et al, 1993). However, concerning melanoma, several epidemiological studies, including our own, have found an increased risk of melanoma associated with use of sunscreens (Autier et al, 1995;Beitner et al, 1990;Elwood and Gallagher, 1999;Graham et al, 1985;Herzfeld et al, 1993;Klepp and Magnus, 1979;Westerdahl et al, 1995).…”

mentioning

confidence: 99%

Sunscreen use and malignant melanoma

et al. 2000

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“…Two randomized trials showed a significant protective effect of use of sunscreens against actinic keratoses (Thompson et al, 1993;Naylor et al, 1995).…”

Section: Squamous-cell Carcinomamentioning

confidence: 99%