High serum level of macrophage-colony stimulating factor (M-CSF) in adult-onset Still's disease.

Matsui, K; Tsuchida, Takaya; Hiroishi, Kazumasa; Tominaga, Kentaro; Hayashi, Nobuhiko; Hada, Tetsuya; Higashino, Koji

doi:10.1093/rheumatology/38.5.477

Cited by 45 publications

(22 citation statements)

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“…Furthermore, a higher release of several other cytokines, including IL-6, IL-8 [19] and, in particular, IL-18, which will be described more in detail in the biomarkers section, has been reported [20]. An increased production of macrophage stimulating colony factor [21], a molecule responsible for macrophage activation -one of the main pathogenic events of disease -has also been detected.…”

Section: Aosd Pathogenesismentioning

confidence: 90%

Presentation and diagnosis of adult-onset Still’s disease: the implications of current and emerging markers in overcoming the diagnostic challenge

Colafrancesco¹,

Priori²,

Valesini³

2015

Expert Review of Clinical Immunology

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Adult-onset Still's disease (AOSD) is a known cause of fever of unknown origin. It is characterized by a triad of symptoms: spiking fever (>39°C), salmon-colored rash and arthritis/arthralgia. On a predisposing genetic background, several conditions may act as trigger for disease and among these, infectious agents are the most important. Nowadays, a dichotomous view of AOSD has been introduced which distinguishes this entity in two subsets according to the clinical features and laboratory aspects: systemic or articular. As AOSD is a diagnosis of exclusion, specific biomarkers able to facilitate differential diagnosis are needed. A number of possible biomarkers have been proposed that will be discussed in detail in this review: ferritin, IL-18, procalcitonin, s100 proteins and sCD163.

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Section: Aosd Pathogenesismentioning

confidence: 90%

Presentation and diagnosis of adult-onset Still’s disease: the implications of current and emerging markers in overcoming the diagnostic challenge

Colafrancesco¹,

Priori²,

Valesini³

2015

Expert Review of Clinical Immunology

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“…Many markers reflecting the activation of monocyte lineage are correlated with AOSD activity. Macrophage-colony stimulating factor (M-CSF) and interferon (IFN)-c, together with calprotectin, MIF, and intracellular adhesion molecule-1 (ICAM-1) have also been reported as useful markers for AOSD activity [35,37].…”

Section: Geneticsmentioning

confidence: 99%

Pathogenesis of adult-onset Still’s disease: new insights from the juvenile counterpart

et al. 2014

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Adult-onset Still's disease (AOSD) is a rare inflammatory disease characterized by the classical triad of daily fever, arthritis, and typical salmon-colored rash. Recent accumulation of knowledge, mostly arising from hereditary autoinflammatory diseases and from the systemic-onset juvenile idiopathic arthritis (sJIA), has given raise to new hypotheses on the pathophysiology of AOSD. In this review, we first discuss on the continuum between AOSD and sJIA. Then, we summarize current hypotheses on the underlying pathogenesis: (1) an infectious hypothesis; (2) an autoinflammatory hypothesis; (3) a lymphohistiocytic hypothesis; and (4) a hyperferritinemic hypothesis. Finally, we present the recent data suggesting that patients with AOSD fall into two distinct subgroups with different courses, one with prominent systemic features and one with chronic arthritis.

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“…Several cytokines are involved in AOSD [6]- [14]. IL-18, secreted by activated macrophages, Kuppfer cells, dendritic cells, and keratinocytes, is involved in hepatic cytolysis, joint damage, activation of T CD4 cells, production of IFN γ, macrophage activation and increased IgE [6].…”

Section: Cytokinesmentioning

confidence: 99%

Adult Onset Still’s Disease

Mahfoudhi¹,

Gorsane²,

Shimi³

et al. 2015

IJCM

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The adult onset Still's disease is a rare affection characterised by occurrence of fever, arthralgia or arthritis and evanescent cutaneous eruption. Multiple other systemic lesions make the diagnosis more difficult. Several diagnostic criteria were formulated to confirm this disease. The physiopathology of the adult onset Still's disease is not well elucidated. However, several studies based on new facts in physiopathology, improved the therapy of refractory forms for which the biotherapy was an interesting alternative. The TNF alpha receptor antagonists are efficient on systemic and articular manifestations of this disease and allow a corticosteroid's saving. Tocilizumab (interleukin 6 receptor antagonist), and Anakinra (interleukin 1 receptor antagonist) are also new promising treatments for resistant forms.

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High serum level of macrophage-colony stimulating factor (M-CSF) in adult-onset Still's disease.

Cited by 45 publications

References 0 publications

Presentation and diagnosis of adult-onset Still’s disease: the implications of current and emerging markers in overcoming the diagnostic challenge

Presentation and diagnosis of adult-onset Still’s disease: the implications of current and emerging markers in overcoming the diagnostic challenge

Pathogenesis of adult-onset Still’s disease: new insights from the juvenile counterpart

Adult Onset Still’s Disease

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