High Seroprevalence of &lt;i&gt;Helicobacter pylori&lt;/i&gt; in Chronic Bronchitis among Chinese Population

Zhao, Jingbo; Yang, Lei; Shimizu, Yasuo; Dobashi, Kunio; Mori, Masataka

doi:10.1620/tjem.208.327

Cited by 20 publications

(16 citation statements)

References 24 publications

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“…Helicobacter pylori (H. pylori) is a microaerophilic spiral-shaped gram negative bacterium that chronically infects the stomach of more than 50% of the human population (varying from over 70% in developing countries to less than 40% in developed countries) and represents the major cause of gastroduodenal pathologies Science Publications AJI (e.g., chronic active gastritis, peptic ulcer, B-cell lymphoma and gastric carcinoma) (Wotherspoon et al, 1999;Parsonnet et al, 1991;D'Elios et al, 1997). Some recent epidemiologic and serologic studies have reported a relationship between H. pylori seropositivity, especially of the high virulent cytotoxin-asssociated gene A (CagA) positive strains and extra-gastroduodenal diseases, such as vascular (coronary artery disease and stroke), metabolic (autoimmune atrophic thyroiditis), rheumatic (Henoch-Schönlein purpura), dermatologic (chronic urticaria and rosacea), as well as respiratory diseases (chronic bronchitis, COPD, bronchiectasis, asthma and lung cancer) (Whincup et al, 1996;Luis et al, 1998;Tsang et al, 1998;Roussos et al, 2006;Jun et al, 2006;Behroozian and Moradkhan, 2010). The activation of inflammatory mediators as a result of systemic immune response induced by H. pylori infection may be potential explanation for these associations (Kanbay et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

HELICOBACTER PYLORI INFECTION IN NEVER-SMOKING MALE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS RELATION TO LUNG FUNCTION

Minov¹

2012

American Journal of Immunology

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There is a recent epidemiologic and serologic evidence for relationship between Helicobacter pylori (H. pylori) infection and Chronic Obstructive Pulmonary Disease (COPD). In order to assess the relationship between H. pylori infection and COPD and its impact on lung function we performed a cross-sectional study including 84 never-smoking male patients with COPD and an equal number of never-smoking males without chronic respiratory disease matched to the COPD patients by age. Evaluation of the study subjects included evaluation of H. pylori serological status, baseline and postbronchodilator spirometry. We found significantly higher H. pylori seropositivity in COPD patients than in controls (76.2 Vs 34.5%, p = 0.041). The prevalence of H. pylori seropositivity did not differ significantly between patients with mild, moderate and severe COPD. Borderline significance was registered for the difference of the forced expiratory volume in one second (FEV 1 ) mean value between seropositive and seronegative COPD patients (56.4 vs. 59.2, p = 0.063). The mean degree of FEV 1 reversibility did not differ significantly between seropositive and seronegative COPD patients. Our findings indicate that in cross-sectional analysis there is higher prevalence of H. pylori seropositivity in COPD than in non-COPD patients, as well as that H. pylori infection has not significant impact on lung function in COPD patients.

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Section: Introductionmentioning

confidence: 99%

HELICOBACTER PYLORI INFECTION IN NEVER-SMOKING MALE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS RELATION TO LUNG FUNCTION

Minov¹

2012

American Journal of Immunology

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“…The full texts of 22 articles were then obtained for more careful examination. After strict application of the inclusion and exclusion criteria, 9 case-control studies 11,12,[17][18][19][20][21][22][23] were finally selected for inclusion in the meta-analysis. All these articles were in English.…”

Section: Literature Search and Meta-analysis Databasementioning

confidence: 99%

“…If incomplete reversal of airway obstruction was confirmed by spirometry (postbronchodilator forced expired volume in 1 s [FEV 1 ] <80% predicted, along with FEV 1 /FVC <70%), a diagnosis of COPD was given. Of the studies included, 8 used radioimmunoassay (ELISA) for IgG serological detection of H. pylori 11,12,17,18,[20][21][22][23] and only 1 used the 13 C-urea breath test. 19 Other necessary data were included in the meta-analysis forest plot (Fig.…”

Section: Literature Search and Meta-analysis Databasementioning

confidence: 99%

“…Four case-control studies with 318 cases and 332 controls 18,20,21,23 were included in the chronic bronchitis subgroup, and the other 5 studies, with 464 cases and 483 controls, 11,12,17,19,22 were included in the COPD subgroup. The OR for the chronic bronchitis subgroup was 2.90 (95% CI: 2.04-4.13) and the Z-value for the overall effect test was 5.92 (P<.05) (Fig.…”

Section: Quantitative Synthesismentioning

confidence: 99%

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Association Between Chronic Respiratory Diseases and Helicobacter pylori: A Meta-Analysis

Wang

Guan

et al. 2015

Archivos de Bronconeumología (English Edition)

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“…Rosenstock et al [46] showed a higher COPD prevalence in H. pylori IgG-seropositive women compared with uninfected women. Jun et al [47] found an H. pylori seroprevalence of 86.9% in patients with chronic bronchitis compared to 60.4% in controls, also with significant CagA seropositivity. Two case-control studies from Greece demonstrated anti- H. pylori and anti-CagA seropositivity being significantly higher in patients with COPD than in control subjects [48,49].…”

Section: Copd and H Pylorimentioning

confidence: 99%

Helicobacter pylori Infection and the Respiratory System: A Systematic Review of the Literature

Malfertheiner

Kandulski²,

Schreiber³

et al. 2011

Digestion

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Background: Recent studies suggest an increased Helicobacter pylori prevalence in patients with various extradigestive inflammatory diseases. Similar to H. pylori infection, many respiratory diseases are characterized by chronic inflammation as well as increased immune response. Recent studies have evaluated the relation between various respiratory disorders and H. pylori infection. The aim of this systematic review was to scrutinize the relevant literature and the mechanisms that could underlie a role for H. pylori infection in respiratory diseases. Methods: Relevant literature regarding pathophysiological mechanisms and clinical epidemiology of H. pylori and different respiratory diseases has been systematically identified and analyzed by two independent reviewers according to a PubMed search for English language (until week 14, April 2010). Conclusions: At present, there is no definite proof of a causal relationship between H. pylori and respiratory diseases. Both H. pylori and various respiratory diseases are characterized by the release of proinflammatory cytokines and attraction of granulocytes as well as B- and T-cell-mediated response, though a pathophysiological association has not been proven. Neither the role of genetic predisposition of the host nor the presence of virulence factors nor the impact of H. pylori eradication have been studied in detail and definitely need further evaluation.

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High Seroprevalence of <i>Helicobacter pylori</i> in Chronic Bronchitis among Chinese Population

Cited by 20 publications

References 24 publications

<I>HELICOBACTER PYLORI</I> INFECTION IN NEVER-SMOKING MALE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS RELATION TO LUNG FUNCTION

<I>HELICOBACTER PYLORI</I> INFECTION IN NEVER-SMOKING MALE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS RELATION TO LUNG FUNCTION

Association Between Chronic Respiratory Diseases and Helicobacter pylori: A Meta-Analysis

<i>Helicobacter pylori</i> Infection and the Respiratory System: A Systematic Review of the Literature

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