High Sensitivity Plastic-Substrate Photonic Crystal Biosensor

Block, Ian D.; Pineda, Maria F.; Choi, Charles J.; Cunningham, Brian T.

doi:10.1109/jsen.2008.924377

Cited by 22 publications

(9 citation statements)

References 4 publications

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“…Schmid at NRC reported large area PhC sensor region using SOI wafer [41]. Block et al fabricated TiO 2 periodic structures on an epoxy [42] and porous SiO 2 undercladding [43] and reported the sensitivity of Δλ/Δn =306.7 nm/RIU (refractive index unit).…”

Section: Sensor Application Of Gmrmentioning

confidence: 99%

Photonic crystals for the application to spectrometers and wavelength filters

Ohtera

Yamada

2013

IEICE Electron. Express

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This paper reviews the application of photonic crystals (PhCs) and related periodic structures to spectrometers and wavelength filters. In the first half of the paper in-plane type spectrometers utilizing superprism effect are reviewed. In the latter half out-of-plane and surface-normal type devices, where guided mode resonance (GMR) plays a center role, are described. Finally, Bragg reflection type wavelength filters are dealt with. Keywords: spectrometer, photonic crystal, superprism, subwavelengh grating, guided mode resonance, wavelength filter Classification: Fiber optics, Microwave photonics, Optical interconnection, Photonic signal processing, Photonic integration and systems Lightwave Technol., vol. 16, no. 4, pp. 631-638, 1998. [7] J. Song and N. Zhu, "Design and fabrication of compact etched diffraction grating demultiplexers based on a-Si nanowire technology," Electron. Lett., vol. 44, no. 13, pp. 816-817, 2008. [8] B. Momeni, M. Askari, E. S. Hosseini, A. Atabaki, and A. Adibi, "An on-chip silicon grating spectrometer using a photonic crystal reflector," References

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Section: Sensor Application Of Gmrmentioning

confidence: 99%

Photonic crystals for the application to spectrometers and wavelength filters

Ohtera

Yamada

2013

IEICE Electron. Express

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“…19). [143] When illuminated with white light at normal incidence, the structure reflects a narrow frequency band with near-100% efficiency. A receptor for the protein lactoferrin was immobilized to the surface of the device; lactoferrin binding events could be detected by a positive shift in the wavelength of the reflectance peak.…”

Section: Photonic-crystal Sensorsmentioning

confidence: 99%

“…A receptor for the protein lactoferrin was immobilized to the surface of the device; lactoferrin binding events could be detected by a positive shift in the wavelength of the reflectance peak. [143] In the simple case of porous 1D photonic structures, analytes can condense from the gas phase into the pores of the photonic crystal, changing the refractive index of these layers. The change in the dielectric contrast induces a modification in the reflectance, which can be related to the quantity of condensed analyte.…”

Section: Photonic-crystal Sensorsmentioning

confidence: 99%

Multidimensional Architectures for Functional Optical Devices

Arpin¹,

Mihi²,

Johnson³

et al. 2010

Advanced Materials

174

154

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Materials exhibiting multidimensional structure with characteristic lengths ranging from the nanometer to the micrometer scale have extraordinary potential for emerging optical applications based on the regulation of light-matter interactions via the mesoscale organization of matter. As the structural dimensionality increases, the opportunities for controlling light-matter interactions become increasingly diverse and powerful. Recent advances in multidimensional structures have been demonstrated that serve as the basis for three-dimensional photonic-bandgap materials, metamaterials, optical cloaks, highly efficient low-cost solar cells, and chemical and biological sensors. In this Review, the state-of-the-art design and fabrication of multidimensional architectures for functional optical devices are covered and the next steps for this important field are described.

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“…The DFBLB demonstrates single mode operation over a total wavelength range of 20 nm in which the lasing wavelength is linearly proportional to the bulk refractive index of the liquid media on its surface [22]. A bulk refractive index sensitivity, as defined by S b = λ/ n, (where λ is the shift in lasing wavelength when the sensor surface is exposed to a bulk refractive index change of n) of S b = 100 nm/RIU (RIU = refractive index units) has been obtained for previous devices, which is not as large as that obtained for SPR (S b = 1000 nm/RIU, Q = 10 [1]) and photonic crystal biosensors (S b = 300 nm/RIU, Q = 1000 [26]), but larger values reported for microring resonators (S b = 36 nm/RIU, Q = 1000 [27]) and microtoroids (S b = 30 nm/RIU, Q = 106 [28]) .…”

Section: Introductionmentioning

confidence: 97%

Distributed Feedback Laser Biosensor Noise Reduction

Tan

Chu

et al. 2013

IEEE Sensors J.

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Label-free biosensors based upon detection of shifts in the emission wavelength, which occur when biological analytes are adsorbed on the surface of a solid-state laser, represent an important new class of sensors that can simultaneously provide high sensitivity and high resolution. We report on a signal processing approach that enables detection of lasing wavelength shifts as small as λ ∼ 1.5 pm from a distributed feedback laser biosensor (DFBLB) fabricated upon a flexible plastic substrate and incorporated into standard-format microplates. Because the DFBLB can be optically pumped in a pulsed mode at a repetition rate that is substantially faster than the rate of biomolecular binding interactions, noise may be reduced through the ability to average multiple independent readings through integration of many lasing spectra within a single spectral integration period, and to subsequently use boxcar averaging to collapse multiple readings in a time sequence to a single time point. We have observe that the DFBLB occasionally produces nonclassical output spectra that can lead to an increase in wavelength shift noise, and therefore we implement a statistical metric to automatically determine whether an acquired spectrum should be discarded from analysis. The combined approaches are used to demonstrate the ability to detect a protein-protein interaction with an analyte concentration that would not otherwise be observable over background noise.

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High Sensitivity Plastic-Substrate Photonic Crystal Biosensor

Cited by 22 publications

References 4 publications

Photonic crystals for the application to spectrometers and wavelength filters

Photonic crystals for the application to spectrometers and wavelength filters

Multidimensional Architectures for Functional Optical Devices

Distributed Feedback Laser Biosensor Noise Reduction

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