Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.03.057 View full text
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Ryo Ishibashi, Kazuma Mawatari, Takehiko Kitamori

Abstract: The rapidly developing interest in nanofluidics, which is used to examine liquids on an order that ranges from an attoliter to a femtoliter, correlates with the recent interest in decreased sample amounts, such as in the field of single-cell analysis. In this paper, we have succeeded in the normal phase separation of a 10(1) fL sample with a high number of theoretical plates (10(3) plates), and a fast separation (4 s), using a pressure-driven flow in extended nanochannels. A meander separation channel 1 μm wid…

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