High resolution MRI and MRS: A feasibility study for the investigation of focal cerebral ischemia in mice

ADC characterization of region‐specific response to cerebral perfusion deficit in rats by MRI at 9.4 T

“…Excluding the piriform cortex, the lowest changes in CBF and ADC were observed in the frontal cortex (usually qualified as ischemic penumbra in this model) and hypothalamus. The study of the MCAO in mice also indicated the presence of a penumbral region, i.e., that the perfusion deficit occupied a larger area than the ADC lesion (25). Recently, a correlation was found between the ADC and perfusion changes in areas with only mild to moderate perfusion deficits toward the lesion periphery in a rat model of MCAO (13).…”

Sensitivity and Source of Amine‐Proton Exchange and Amide‐Proton Transfer Magnetic Resonance Imaging in Cerebral Ischemia

“…Reduction in NAA concentration has been widely reported in rat and human brains under ischemic conditions (40)(41)(42)(43)(52)(53)(54)(55)(56)(57)(58)(59). A 30-70% decrease of total creatine concentration within a few hours of permanent MCAO onset has been reported in the literature, comparable to our result (35615% at $4 h) (42,45,46). MCAO also resulted in reductions of Glu and Tau concentrations, consistent with earlier findings (50,(60)(61)(62).…”

Localized proton MRS of cerebral metabolite profiles in different mouse strains

“…Similar to other mammals, the MR spectra reveal resonances of major cerebral metabolites such as tNAA, tCr, Cho, and Ins, as well as Glc and Lac. The resulting SNR turned out to be sufficient for a reliable spectral evaluation by LCModel and comparable to another proton MRS study of mice brain (24). Mean cerebral metabolite concentrations are summarized in Table 2.…”