J. Kool, A.F. Rudebeck, F. Fleurbaaij, S. Nijmeijer, D. Falck, R.A. Smits, H.F. Vischer, R. Leurs, W.M.A. Niessen
Abstract:In the past years we developed high-resolution screening platforms involving separation of bioactive mixtures and on-line or at-line bioassays for a wide variety of biological targets with parallel mass spectrometric detection and identification. In the current research, we make a major step forward in the development of at-line bioassays by implementation of radioligand receptor binding and functional cellular assays to evaluate bioactvity and selectivity. We demonstrate a new platform for high-resolution met…
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