High resolution LAPS and SPIM

Chen, Li; Zhou, Ying‐Lin; Jiang, Shihong; Kunze, Julia; Schmuki, Patrik; Krause, Steffi

doi:10.1016/j.elecom.2010.03.026

Cited by 54 publications

(76 citation statements)

References 15 publications

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“…The detailed set-up is shown in Figure S2 and was previously shown to have a resolution of 0.8 µm [17]. A schematic of the photocurrent curves recorded is shown in Figure 2b. …”

Section: Spim Measurementsmentioning

confidence: 99%

“…Submicrometre resolution for SPIM and LAPS has been achieved using silicon on sapphire (SOS, 0.5 µm silicon, 475 µm sapphire) as the semiconductor substrate and photoexcitation of charge carriers using a two photon-effect in the thin silicon layer by employing a femtosecond laser (1250 nm) with photon energy smaller than the bandgap of silicon [17]. By replacing the traditional insulator with a selfassembled organic monolayer that was bound to hydrogen-terminated silicon on the SOS substrate, we have significantly increased the sensitivity of SPIM and the measurement accuracy of LAPS recently [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…SPIM is based on photocurrent measurement at electrolyte-insulatorsilicon (EIS) field-effect structures and can provide a two-dimensional impedance image of the sample surface [17][18][19]. A bias voltage is applied between the semiconductor and a reference electrode immersed in the electrolyte to obtain an inversion layer, and a modulated light beam focused into the semiconductor scans across the substrate to generate electron/hole pairs.…”

Section: Introductionmentioning

confidence: 99%

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The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy

Wang

Campos

et al. 2016

Electrochimica Acta

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Abstract:Polyelectrolyte microcapsules have attracted great interest in drug delivery applications, and microcapsules modified with gold nanoparticles have been used in this way with triggered release when a laser can be used to remotely open shells through light-induced local heating. The electrical impedance of unmodified microcapsules has been studied due to its implications for their permeability, however, the impedance of functionalised microcapsules has not yet been investigated. Herein, the impedance of microcapsules modified with gold nanoparticles was studied for the first time. It was shown that the modification of microcapsules with gold nanoparticles leads to a much greater impedance than would be expected from the increase in the thickness caused by the presence of a layer of gold nanoparticles alone. The impedance of gold nanoparticle modified capsules was measured using scanning photo-induced impedance microscopy 2 (SPIM), which is based on photocurrent measurements at an electrolyte-insulatorsemiconductor (EIS) field-effect structure. High resolution and good sensitivity were achieved using a two-photon effect for charge carrier excitation and organic monolayer modified silicon on sapphire (SOS) as the SPIM substrate. SPIM allowed impedance imaging of collapsed microcapsules with unprecedented detail. SPIM images of capsules labelled with gold nanoparticles (AuNPs) showed a good agreement with the corresponding optical images, including the creases resulting from the collapse of the hollow shells. The significant increase in impedance caused by the impregnation with AuNPs was also verified by conductive Atomic Force Microscopy (C-AFM) measurements in the dry state.

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“…The detailed set-up is shown in Figure S2 and was previously shown to have a resolution of 0.8 µm [17]. A schematic of the photocurrent curves recorded is shown in Figure 2b. …”

Section: Spim Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy

Wang

Campos

et al. 2016

Electrochimica Acta

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“…The setup for LAPS and SPIM measurements was described previously [17]. A diode laser LD1539 (Laser 2000, λ= 405 nm, 1 mW) was used for photocurrent excitation.…”

Section: Laps Measurementsmentioning

confidence: 99%

“…Using an optimized laser scanning setup in conjunction with a silicon-onsapphire (SOS) substrate (Figure 1), 1.5 µm spatial resolution was obtained using visible light with a wavelength of 405 nm, and 0.8 µm resolution was achieved using light with energy smaller than the bandgap exciting a two-photon effect in silicon [17,18]. To improve the sensitivity of the LAPS surface, the traditional insulator was replaced with a 1,8-nonadiyne monolayer that was bound to hydrogen terminated silicon on SOS [19,20].…”

Section: Introductionmentioning

confidence: 99%

Image detection of yeast Saccharomyces cerevisiae by light-addressable potentiometric sensors (LAPS)

Zhang

Wang

et al. 2016

Electrochemistry Communications

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Bipolar Light‐Addressable Potentiometric Sensor Based on Fullerene Photosensitive Layer

Jiao

Zhang

et al. 2021

Adv Materials Technologies

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Light‐addressable potentiometric sensor (LAPS) is highly attractive in many sectors, including human disease detection, drug screening, and environmental monitoring. Currently, classical LAPS chips adopt inorganic semiconductors, such as silicon, as the photosensitive layer. Organic semiconductors can provide the next generation of the photosensitive layer because of their high absorption efficiency, large structural variability, eco‐friendliness, and bendability. However, no promising organic materials have been reported so far for the construction of LAPS chips. Here, the authors demonstrate the potential of fullerene (C60), a π‐conjugated carbon molecule with high n‐type conduction, as a candidate material for the photosensitive layer of LAPS. They report on a peculiar bipolar photo‐response under both reverse and forward biased conditions for C60‐based LAPS. An oxygen‐trap‐induced space‐charge mechanism is proposed to explain the unique bipolar photo‐response phenomenon. The proposed C60‐based LAPS exhibits an excellent pH sensitivity of 150 mV/pH as well as a high spatial resolution of 3.8 µm. The authors anticipate that these results will spark interest in this field and enable the replacement of the inorganic‐semiconductor photosensitive layer by organic semiconductor materials for the construction of high‐performance LAPS.

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High resolution LAPS and SPIM

Cited by 54 publications

References 15 publications

The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy

The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy

Image detection of yeast Saccharomyces cerevisiae by light-addressable potentiometric sensors (LAPS)

Bipolar Light‐Addressable Potentiometric Sensor Based on Fullerene Photosensitive Layer

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