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citations
Cited by 58 publications
(71 citation statements)
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References 15 publications
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“…A previous study in Rio de Janeiro involving 2,135 HC revealed seropositivity rate of 16% (19) , while a study in hyperendemic municipalities in the Brazilian Amazon Region involving 1,592 school children revealed a seropositivity of 48.8%, and of 256 HC, 41.8% were seropositive for APGL-I (20) . In the endemic areas of Brazil, the expected APGL-I seropositivity rate is 7% among non-contacts and 10% among HC (14) .…”
Section: Discussionmentioning
confidence: 80%
“…A previous study in Rio de Janeiro involving 2,135 HC revealed seropositivity rate of 16% (19) , while a study in hyperendemic municipalities in the Brazilian Amazon Region involving 1,592 school children revealed a seropositivity of 48.8%, and of 256 HC, 41.8% were seropositive for APGL-I (20) . In the endemic areas of Brazil, the expected APGL-I seropositivity rate is 7% among non-contacts and 10% among HC (14) .…”
Section: Discussionmentioning
confidence: 80%
“…According to the leprosy prevalence rate, FD has been considered a non-endemic area since 2005 [23]; however, the present recruitment procedure resulted in a different scenario with a very high percentage of new cases of leprosy, similar to what one would expect from a hyperendemic area [12, 24]. This fact can be explained by an expected high sensitivity in the screening strategies incorporating our passive random surveillance strategy.…”
Section: Discussionmentioning
confidence: 91%
“…Anti-PGL-I antibodies are found in high concentrations in the sera of MB patients [9] and are correlated with the bacterial index [10, 11]. This specific humoral response has been investigated as an auxiliary tool for diagnosis [12, 13], although its utility in active surveillance remains uncertain [14]. Antibody responses to other antigens, such as Leprosy IDRI Diagnostic (LID)-1 protein, a fusion of two well-recognized M .…”
Section: Introductionmentioning
confidence: 99%
“…Although this test is useful for detection of most multibacillary (MB) patients [15], [16], as the antibody levels correlate well with the bacillary load, detection of anti-PGL-I Ab has limited value in identifying paucibacillary (PB) leprosy patients [17]. In areas hyperendemic for leprosy more than 50% of young schoolchildren surveyed had positive anti-PGL-I responses [18]. Still, the vast majority of individuals with a positive antibody titer will never develop leprosy [13].…”
Section: Introductionmentioning
confidence: 99%