High Prevalence of Vitamin D Deficiency in Elderly Nursing Home Patients Despite Vitamin Supplements

Goldberg, Todd H.; Hassan, Tahmina; Grant, Richard

doi:10.1016/j.jamda.2007.12.086

Cited by 4 publications

(2 citation statements)

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“…While the relationship between vitamin D levels and COVID-19 vaccine immunogenicity has been investigated by a limited number of studies in healthy adults, little is known about this association in older adults, such as nursing home residents (NHRs). This population is particularly vulnerable to vitamin D deficiency, which is a major public health problem in the NHR population [ 30 , 31 , 32 , 33 ]. Moreover, older adults living in nursing homes (NHs) are known to exhibit impaired antibody responses to COVID-19 vaccination, compared to younger healthy individuals [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

No Significant Association between 25-OH Vitamin D Status and SARS-CoV-2 Antibody Response after COVID-19 Vaccination in Nursing Home Residents and Staff

Meyers

Smet

Vercruysse³

et al. 2023

Vaccines

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Vitamin D is an essential nutrient for various physiological functions, including immunity. While it has been suggested that higher vitamin D levels/supplementation are associated with a better immune response to COVID-19 vaccination, conflicting data exist. Therefore, we aimed to investigate the association between vitamin D (25-hydroxyvitamin D) deficiency/supplementation, and SARS-CoV-2 antibody responses post-vaccination in nursing home residents (NHRs) and staff (NHS). Blood samples were collected from 115 NHRs and 254 NHS at baseline and 14 days after primary course BNT162b2 vaccination. Baseline samples were assessed for serum 25-hydroxyvitamin D levels, while follow-up samples were analyzed for spike protein S1 receptor-binding domain (S1RBD) IgG antibody concentrations and 50% pseudoneutralization titers. Vitamin D supplementation status was obtained from NHRs medical records. We compared immune responses between (severe) vitamin D-deficient and -sufficient NHRs/NHS and between supplemented and non-supplemented NHRs, stratified for history of SARS-CoV-2 infection and participant type. No significant differences in either binding or neutralizing COVID-19 vaccine antibody response were found between groups. The prevalence of vitamin D deficiency (<20 ng/mL) was 45% (95% CI: 36–54%) among NHRs and 60% (95% CI: 54–66%) among NHS. Although we showed that vitamin D status may not be related to a better COVID-19 vaccine antibody response, addressing the high prevalence of vitamin D deficiency in the nursing home population remains important.

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Section: Introductionmentioning

confidence: 99%

No Significant Association between 25-OH Vitamin D Status and SARS-CoV-2 Antibody Response after COVID-19 Vaccination in Nursing Home Residents and Staff

Meyers

Smet

Vercruysse³

et al. 2023

Vaccines

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show abstract

“…43% of US COVID 19 deaths have occurred in nursing homes 16 . 84-93% of US nursing home patients have insufficient vitamin D levels 17,18 .…”

Section: Main Textmentioning

confidence: 99%

Double COVID-19 Confirmed Case Fatality Rate in Countries with High Elderly Female Vitamin D Deficiency Prevalence

Bäcker

Mageswaran

2020

Preprint

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A number of clues point to a possible role of vitamin D in fighting COVID-19: a reduction in case growth speed with solar zenith angle, higher fatality rate in black people, lower fatality rate in populations that spend more time outdoors. Yet a direct demonstration that vitamin D deficiency is associated with COVID-19 fatalities has remained elusive. We show here in a comparison of 32 countries that countries with high prevalence of vitamin D deficiency among elderly females show a confirmed case fatality rate twice as high as those with low prevalence. We then show that this effect cannot be explained by differences in life expectancy between countries. A mechanistic role for vitamin D in the severity of COVID-19 is proposed.

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Weight and Nutrition in Post-Acute and Long-Term Care

Goldberg

Levien

2023

Current Clinical Practice

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High Prevalence of Vitamin D Deficiency in Elderly Nursing Home Patients Despite Vitamin Supplements

Cited by 4 publications

References 0 publications

No Significant Association between 25-OH Vitamin D Status and SARS-CoV-2 Antibody Response after COVID-19 Vaccination in Nursing Home Residents and Staff

No Significant Association between 25-OH Vitamin D Status and SARS-CoV-2 Antibody Response after COVID-19 Vaccination in Nursing Home Residents and Staff

Double COVID-19 Confirmed Case Fatality Rate in Countries with High Elderly Female Vitamin D Deficiency Prevalence

Weight and Nutrition in Post-Acute and Long-Term Care

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