High prevalence of undiagnosed diabetes mellitus in Southern Germany: Target populations for efficient screening. The KORA survey 2000

Rathmann, Wolfgang; Haastert, Burkhard; Icks, Andrea; Löwel, Hannelore; Meisinger, Christa; Holle, Rolf; Giani, Guido

doi:10.1007/s00125-002-1025-0

Cited by 507 publications

(448 citation statements)

References 24 publications

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“…Cooperative Health Research in the Region of Augsburg Survey 4 (KORA S4) study population has been described extensively (25)(26)(27)(28)(29). In the age range 55-74 years, 120 individuals with newly diagnosed type 2 diabetes (and thus without antidiabetic treatment, which could interfere with adiponectin and immune marker levels) and 242 subjects with impaired glucose tolerance (IGT) were available for analysis.…”

Section: Research Design and Methods -The Population-basedmentioning

confidence: 99%

“…The measurement of anthropometric parameters, metabolic and immunological variables (from fasting blood samples), blood pressure, and the assessment of alcohol intake, smoking, and physical activity has been described previously (25)(26)(27)(28)(29). Hypertension was defined as use of antihypertensive treatment or systolic blood pressure Ն140 mmHg or diastolic blood pressure Ն90 mmHg.…”

Section: Research Design and Methods -The Population-basedmentioning

confidence: 99%

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Hypoadiponectinemia and Proinflammatory State: Two Sides of the Same Coin?

et al. 2006

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OBJECTIVE -Previous studies have yielded conflicting results on the association of adiponectin levels and inflammation. Low systemic concentrations of adiponectin, as well as elevated levels of immune mediators, represent risk factors for the development of type 2 diabetes and coronary artery disease. The major aim of this cross-sectional study was to investigate the interdependence of hypoadiponectinemia and low-grade systemic inflammation. ; 1999 -2001). Systemic concentrations of adiponectin and a wide range of anthropometric, metabolic, and inflammatory variables were available for analyses. The association of adiponectin with 15 immunological markers, including leukocyte count, acute-phase proteins, cytokines, cytokine receptors, and chemokines, was assessed using univariable and multivariable models. RESEARCH DESIGN AND METHODSRESULTS -No evidence for a significant correlation between adiponectin and all immunological parameters except eotaxin could be found after multivariable adjustments, whereas multiple strong correlations with obesity and metabolic factors were present.CONCLUSIONS -From these data, we conclude that hypoadiponectinemia and a proinflammatory state are largely independent from each other.

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Section: Research Design and Methods -The Population-basedmentioning

confidence: 99%

Section: Research Design and Methods -The Population-basedmentioning

confidence: 99%

Hypoadiponectinemia and Proinflammatory State: Two Sides of the Same Coin?

et al. 2006

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“…The study designs have been described in detail elsewhere 9,18,39 unrelated men and women between 25 and 74 years of age. All subjects had to complete a standardised questionnaire, that, in addition to demographic data included the basic allergy questions of the European Community Respiratory Health Survey (ECRHS) on respiratory health 40 .…”

Section: Study Populationsmentioning

confidence: 99%

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk

Weidinger

Baurecht

Wagenpfeil

et al. 2008

Journal of Allergy and Clinical Immunology

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“…The KORA Survey 2000, a population-based study on prevalence of diabetes and IGT in a 55-to 74-year-old population in Germany reported a total diabetes prevalence of about 17%; an additional 23% of the population had IGT or IFG. Half of the total cases with diabetes were previously undiagnosed [3]. Thus, the prevalence of abnormal glucose tolerance found in southern Germany is among the highest reported in European countries [4][5][6], emphasising the need for prevention.…”

Section: Introductionmentioning

confidence: 99%

Leisure time physical activity and the risk of type 2 diabetes in men and women from the general population

et al. 2004

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Aims/hypothesis: The aim of this study was to examine sex-specific associations between leisure time physical activity and incident type 2 diabetes in a representative population sample in Germany. Methods: The study was based on 4,069 men and 4,034 women (aged 25 to 74 years) who participated in one of the three MONICA Augsburg surveys between 1984 and 1995. Subjects were free of diabetes at baseline. Incident cases of type 2 diabetes were assessed in 1998 using a follow-up questionnaire. Sex-specific hazard ratios (HRs) were estimated from Cox proportional hazard models. Results: A total of 145 cases of incident type 2 diabetes among men and 82 among women were registered during the mean follow-up period of 7.4 years. In both sexes, a high leisure time physical activity level was associated with a reduced risk of incident type 2 diabetes. After adjustment for confounding factors, the HR in highly active men (more than 2 h physical activity per week in summer and winter) was 0.83 (95% CI: 0.50-1.36). In contrast, highly active women had the lowest risk of type 2 diabetes even after multivariable adjustment (HR 0.24; 95% CI: 0.06-0.98). In subgroup analyses, after multivariable adjustment, the protective effect of moderate to high physical activity was significant in women with a BMI below 30 kg/m 2 (HR 0.24; 95% CI: 0.09-0.65) but not in women with a BMI of 30 kg/m 2 or higher (HR 0.97; 95% CI: 0.44-2.11). Conclusions/interpretation: Leisure time physical activity is effective in preventing type 2 diabetes, especially in nonobese women, in the general population.

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High prevalence of undiagnosed diabetes mellitus in Southern Germany: Target populations for efficient screening. The KORA survey 2000

Cited by 507 publications

References 24 publications

Hypoadiponectinemia and Proinflammatory State: Two Sides of the Same Coin?

Hypoadiponectinemia and Proinflammatory State: Two Sides of the Same Coin?

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk

Leisure time physical activity and the risk of type 2 diabetes in men and women from the general population

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