High Prevalence of Thyroid Dysfunction Among Pregnant Women in Lubumbashi, Democratic Republic of Congo

Habimana, Laurence; Twite, K.; Daumerie, Chantal; Wallemacq, Pierre; Donnen, Philippe; Kalenga, M.; Robert, Annie

doi:10.1089/thy.2013.0261

Cited by 20 publications

(23 citation statements)

References 32 publications

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“…The prevalence of hypothyroidism has been reported from different countries very recently. [ 10 11 12 ] On analysis, results of this study are consistent with recently published data from India and other countries. Previous studies conducted in Delhi reported a 14.3% prevalence of hypothyroidism during the first trimester.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of hypothyroidism in pregnancy: An epidemiological study from 11 cities in 9 states of India

Dhanwal

Bajaj

Rajput

et al. 2016

Indian J Endocr Metab

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Background:A previous hospital based study from Delhi revealed a high prevalence of hypothyroidism in pregnant women. Several other studies with small sample size also indicate a rising trend of prevalence of hypothyroidism during pregnancy in India.Objective:To assess prevalence of hypothyroidism in pregnant women from various states/cities across India.Materials and Methods:This was a cross-sectional multicenter study conducted at Allahabad (Uttar Pradesh), Bengaluru (Karnataka), Chennai (Tamil Nadu), Kolkata (West Bengal), Hyderabad (Telangana), Nasik (Maharashtra), Rohtak (Haryana), Pune (Maharashtra), New Delhi (Delhi), Srinagar (Kashmir), and Vizag (Andhra Pradesh) enrolling 2599 pregnant women. Estimation of thyroid stimulating hormone (TSH), free T4, and antithyroid peroxidase (TPO) antibodies was carried out using Roche modular kit using ECLIA technology in a central laboratory.Results:We found in our study population that 13.13% of pregnant women have hypothyroidism (n = 388), using a cutoff TSH level of 4.5 μIU/ml. This prevalence was much higher using the American Thyroid Association criteria. Anti-TPO antibodies were positive in 20.74% of all pregnant women (n = 613), whereas 40% (n = 155) of hypothyroid pregnant women were positive for anti-TPO antibodies.Conclusion:This study concludes that there is a high prevalence of hypothyroidism (13.13%), majority being subclinical in pregnant women during the first trimester from India and universal screening of hypothyroidism may be desirable in our country.

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Section: Discussionsupporting

confidence: 91%

Prevalence of hypothyroidism in pregnancy: An epidemiological study from 11 cities in 9 states of India

Dhanwal

Bajaj

Rajput

et al. 2016

Indian J Endocr Metab

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“…1,19 Thyroid dysfunction has been observed as the most frequent endocrine disorder in pregnant women. 5 We observed thyroid dysfunction in 19 (20.65%) pregnant women and the most common dysfunction was subclinical hypothyroidism (18,19.56%) when the upper normal cutoff value for TSH was taken 6.16 mIU/L. Assay specific reference ranges for thyroid hormones according to pregnancy trimester were unavailable for the kits used in study, so we could not classify the thyroid status accordingly in the present study.…”

Section: 15mentioning

confidence: 74%

Iodine and Thyroid Function Status, and Anti-thyroid Peroxidase Antibody among Pregnant Women in Eastern Nepal

Chaudhary

Khatiwada

Gelal

et al. 2017

J Nepal Health Res Council

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“…In the Democratic Republic of Congo the prevalence of SCH was found to be 8% and the prevalence of isolated hypothyroxinemia was 12%. 16 In a study done on pregnant women in Teheran, Iran, the prevalence of hypothyroidism was found to be 4.2%, of which 89.1% of cases were subclinical. 17 Although the outcomes associated with SCH in pregnancy pose a huge risk for both the mother and her offspring, screening for SCH is not universally carried out in antenatal settings in Saudi Arabia.…”

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confidence: 99%

Prevalence of subclinical hypothyroidism in pregnancy in Saudi Arabia

Shanqeeti

Alkhudairy

Alabdulwahed

et al. 2018

SMJ

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objectives:To estimate the prevalence of subclinical hypothyroidism (SCH) in Saudi Arabia and assess the need for an SCH screening program.Methods:This cross-sectional study was conducted at King Abdulaziz Medical City and the Khashmulaan Clinic at the National Guard Health Affairs, Riyadh, Saudi Arabia in August 2016. All women attending the antenatal clinics were invited to participate in the study. In addition, data were retrieved from the files of pregnant women who had been screened for hypothyroidism from January 2016 to August 2016. A total of 384 pregnant women were included in the study.Results:The prevalence of SCH in pregnant women in this study was 50/384 (13%) with 95% confidence intervals (CIs): 9.82%-16.80%. Pregnant women who were randomly screened using a survey (n=127) were 3 times more likely (OR: 3.1; 95% CI: 1.182 to 8.704, p=0.022) to have SCH compared to pregnant women who were screened based on their physician’s judgement (n=257). Results showed older age (≥40 years) was associated with an insignificant decrease in the risk of SCH.Conclusion:Random screening for SCH in pregnant women showed a higher prevalence in comparison to women who were screened as a result of physician referrals. The results highlight the urgent need for larger studies to investigate the prevalence of SCH as well as the need for an SCH screening program.

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High Prevalence of Thyroid Dysfunction Among Pregnant Women in Lubumbashi, Democratic Republic of Congo

Cited by 20 publications

References 32 publications

Prevalence of hypothyroidism in pregnancy: An epidemiological study from 11 cities in 9 states of India

Prevalence of hypothyroidism in pregnancy: An epidemiological study from 11 cities in 9 states of India

Iodine and Thyroid Function Status, and Anti-thyroid Peroxidase Antibody among Pregnant Women in Eastern Nepal

Prevalence of subclinical hypothyroidism in pregnancy in Saudi Arabia

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