High prevalence of rifampin-resistant tuberculosis in mountainous districts of India

Dorjee, Kunchok; Sadutshang, Tsetan Dorji; Rana, Ravinder S.; Topgyal, Sonam; Phunkyi, Dawa; Choetso, Tsering; Chodon, Tenzin; Parmar, Malik; Singla, Rupak; Paster, Zorba; Chaisson, Richard E.; Kaushal, Kailash C.

doi:10.1016/j.ijtb.2019.08.005

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…Women were more likely to exhibit drug resistance than men, as reported previously. 12,13 Most patients with MDR-TB in our study were between 31 and 60 years old, demonstrating that preventative and control measures for MDR-TB should also target young and middle-aged patients. The higher frequency of MDR-TB in the middle-aged group suggests the possibility of MDR-TB transmission in the community because of the high mobility of youth.…”

Section: Discussionmentioning

confidence: 71%

Analysis of drug resistance and mutation profiles in Mycobacterium tuberculosis isolates in a surveillance site in Beijing, China

et al. 2021

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Objective This study analyzed drug resistance and mutations profiles in Mycobacterium tuberculosis isolates in a surveillance site in Huairou District, Beijing, China. Methods The proportion method was used to assess drug resistance profiles for four first-line and seven second-line anti-tuberculosis (TB) drugs. Molecular line probe assays were used for the rapid detection of resistance to rifampicin (RIF) and isoniazid (INH). Results Among 235 strains of M. tuberculosis, 79 (33.6%) isolates were resistant to one or more drugs. The isolates included 18 monoresistant (7.7%), 19 polyresistant (8.1%), 28 RIF-resistant (11.9%), 24 multidrug-resistant (MDR) (10.2%), 7 pre-extensively drug-resistant (XDR, 3.0%), and 2 XDR strains (0.9%). A higher rate of MDR-TB was detected among previously treated patients than among patients with newly diagnosed TB (34.5% vs. 6.8%). The majority (62.5%) of RIF-resistant isolates exhibited a mutation at S531L in the DNA-dependent RNA polymerase gene. Meanwhile, 62.9% of INH-resistant isolates carried a mutation at S315T1 in the katG gene. Conclusion Our results confirmed the high rate of drug-resistant TB, especially MDR-TB, in Huairou District, Beijing, China. Therefore, detailed drug testing is crucial in the evaluation of MDR-TB treatment.

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Section: Discussionmentioning

confidence: 71%

Analysis of drug resistance and mutation profiles in Mycobacterium tuberculosis isolates in a surveillance site in Beijing, China

et al. 2021

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“…33,36,45,59,64,65 Risk factors for MDR-TB include male gender, age over 60, living in crowded or congested environment using indigenous stove (Chulha), prior TB treatment, contact with an MDR patient, and being from a hilly region. 40,45,59,[68][69][70] India is the country with the greatest rates of TB related morbidity and mortality, along with risk factors such as undernourishment, alcohol smoking, diabetes, and HIV infection (Fig. 7).…”

Section: The Burden Of Tuberculosis In Different States Of Indiamentioning

confidence: 99%

Tuberculosis epidemic in India – a systematic review

Deotale,

Mondal

2023

Eur J Clin Exp Med

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Introduction and aim. India, accounting for approximately 26% of the global tuberculosis (TB) burden with a significant proportion of 0.11 million (6%) pediatric TB cases. The goal of this systematic review paper is to provide a thorough analysis of the TB epidemic in India, including information on the severity of the illness and challenges associated with diagnosis and treatment, the risk factors for transmission and progression of the disease, and the advancements and difficulties encountered in efforts to control at community level. Material and methods. The terms “Tuberculosis in India,” “Drug-Resistant Tuberculosis,” “Tuberculosis and Associated Co-morbidities,” “Diagnosis of Tuberculosis,” “Prevention of Tuberculosis,” and “Treatment of Tuberculosis’’, keywords were used to search in number of international electronic databases, including “Google Scholar,” “PubMed,” and “DOAJ.” Analysis of the literature. Diagnosis and treatment of TB are significantly complicated by co-morbid condition such includes alcoholism, diabetes, HIV, undernutrition, diabetes and HIV. In addition, there may be treatment delays, and the extra-pulmonary or drug-resistant TB due to ignorance, misunderstandings, and lack of education among TB patients, and medical professionals, which ultimately increases morbidity and mortality. Conclusion. Poverty, undernutrition, inadequate healthcare infrastructure, and co-morbidities, which frequently complicate TB diagnosis and treatment, must be addressed in addition to the critical need to prioritize TB research and development.

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Characterization of probes associated with rifampicin resistance in M.tuberculosis detected by GenXpert from a national reference laboratory at Chennai

et al. 2022

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High prevalence of rifampin-resistant tuberculosis in mountainous districts of India

Cited by 4 publications

References 5 publications

Analysis of drug resistance and mutation profiles in Mycobacterium tuberculosis isolates in a surveillance site in Beijing, China

Analysis of drug resistance and mutation profiles in Mycobacterium tuberculosis isolates in a surveillance site in Beijing, China

Tuberculosis epidemic in India – a systematic review

Characterization of probes associated with rifampicin resistance in M.tuberculosis detected by GenXpert from a national reference laboratory at Chennai

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