2015
DOI: 10.1128/aac.04412-14
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Abstract: The main objective of this study was to decipher the molecular mechanism of resistance to carbapenems and aminoglycosides in a large series of 150 Acinetobacter baumannii clinical isolates collected from July 2012 to September 2013 in Egypt. We report for the first time the emergence of bla NDM-1 and the cooccurrence of 16S rRNA methylase armA with bla NDM-1 and bla OXA-23 in Egyptian hospitals. Multilocus sequence typing identified 27 distinct sequence types, 11 of which were novel. Carbapenem and aminoglycos… Show more

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Cited by 49 publications
(49 citation statements)
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“…In addition, the incidence of bla NDM1 producers among the CPKP in our hospital (55.84%) was much higher than that previously reported by Yan et al [8]. Bla NDM1 was first detected in Egypt from one K. pneumoniae isolate in 2013 by Abdelaziz et al [32] and then from two Pseudomonas aeruginosa isolates [33], as well as in Acinetobacter baumannii isolates [34], which indicates that this gene may spread among Enterobacteriaceae by transferable plasmids [35,36].…”
Section: Discussioncontrasting
confidence: 41%
“…In addition, the incidence of bla NDM1 producers among the CPKP in our hospital (55.84%) was much higher than that previously reported by Yan et al [8]. Bla NDM1 was first detected in Egypt from one K. pneumoniae isolate in 2013 by Abdelaziz et al [32] and then from two Pseudomonas aeruginosa isolates [33], as well as in Acinetobacter baumannii isolates [34], which indicates that this gene may spread among Enterobacteriaceae by transferable plasmids [35,36].…”
Section: Discussioncontrasting
confidence: 41%
“…This finding might indicate the prevalence of the genetic environment of bla OXA-23 in Egyptian isolates [16]. Moreover, a recent study including three Egyptian hospitals revealed the emergence and spread of bla NDM-1 and bla OXA-23 in addition to the co-occurrence of 16S rRNA methylase armA with bla NDM-1 and bla OXA-23 in 27 distinct sequence types, 11 of which were novel among A. baumannii clinical isolates [20]. …”
Section: Discussionmentioning
confidence: 99%
“…For example, Doi et al (19) first discovered that two of five A. baumannii isolates coproduced OXA-23 β-lactamase and ArmA in North America in 2007. In addition, further cases were reported in Korea (20,23), India (24), France (25), Bulgaria (26), Italy (27), Latvia (28), East Africa (29), Yemen (30), Japan (31), Brunei (32), Egypt (33) and China (21,34,35). The authors of the present study previously determined that extended-spectrum β-lactamase and 16S rRNA methylase are coproduced in A. baumannii (36).…”
Section: Introductionmentioning
confidence: 99%