High Prevalence of Cutaneous Reactions to Interferon Alfa Plus Ribavirin Combination Therapy in Patients With Chronic Hepatitis C Virus

Sookoian, Silvia; Neglia, V; Castaño, Gustavo Osvaldo; Frider, Bernardo; Kien, María Cristina; Chohuela, E

doi:10.1001/archderm.135.8.1000

Cited by 75 publications

(45 citation statements)

References 3 publications

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“…Complementing this information, Mourad et al (15) affirmed that tumors of positive bone marrow interleukin-2 presented a significantly greater mean of NORs than healthy individuals, and Simark-Mattsson et al (16) stated that the OLP cells of all cases studied by them expressed mRNA for interleukin-2. The previously described cellular events, plus the histochemical results of this study suggest that interferon and/or ribavirin may increase the number of NORs per nucleus in oral mucosa cells, suggesting a possible relationship between anti-HCV treatment and OLP, clinical manifestation previously reported (8,9,12).…”

Section: Discussionsupporting

confidence: 78%

“…Considering the studied groups in this work, it was possible to infer that previously treated HCV+ patients had a higher average number of NORs in relation to others, indicating a higher proliferative activity of tissue, probably due to the effect of anti-HCV treatment which may, according to previous clinical studies (8,9), cause oral manifestations. However, in the current study it was not possible to determine when the HCV infection has initiated, since hepatitis C is often a silent disease, delaying its diagnosis.…”

Section: Discussionmentioning

confidence: 55%

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Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

et al. 2014

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The objective of this study was to evaluate the cellular proliferative potential of oral lichen planus (OLP) lesions from patients without hepatitis C virus (HCV) by means of AgNOR method, as well as the cellular proliferative potential of the normal oral mucosa from patients with HCV, treated or untreated by interferon and ribavirin. A cross-sectional study was developed to investigate four groups: 10 HCV+ patients without clinical signs of OLP who had never been treated for HCV infection -Group 1; 10 HCV+ patients that were under interferon and ribavirin treatment -Group 2; 15 patients with reticular OLP lesions histopathologically confirmed, without HCV -Group 3; and 15 blood donors without HCV infection and no clinical signs of OLP GROUP 4 Control Group. The cytological material of all groups was collected by the liquid-based cytology technique. Then, the sedimented material from each patient was filled with the Nucleolar Organizer Regions impregnation by silver method (AgNOR). The count of NORs was performed on 100 epithelial cell nuclei per patient using the Image Tool™ software. The Tukey HSD test was used to compare the median value of NORs among the groups and showed that the oral mucosa of HCV+ patients previously treated with anti-HCV drugs (GROUP 2), presented a higher average number of NORs in relation to others (p<0.05). The anti-HCV treatment may be related to increased cell proliferation of oral mucosa, indicating a possible relationship between OLP and HCV+ patients treated with interferon and ribavirin.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 55%

Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

et al. 2014

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“…Sookoian et al 21 reported cutaneous reactions in 11 (33%) of 33 patients in Argentina with chronic HCV receiving interferon alfa (2a or 2b not specified) plus ribavirin combination therapy vs 2 (6%) of 35 of those receiving interferon alone. Three of the patients in the combination therapy group developed "eczema," with histologic diagnoses of "subacute psoriasiform dermatitis," "eczema psoriasiform," and "eczema."…”

Section: Commentmentioning

confidence: 99%

Severe, Generalized Nummular Eczema Secondary to Interferon Alfa-2b Plus Ribavirin Combination Therapy in a Patient With Chronic Hepatitis C Virus Infection

Moore¹,

Elpern²,

Carter³

2004

Arch Dermatol

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“…Las reacciones más frecuentes fuera del sitio de inyección son las eccematosas, alcanzando el 59% 1 . Con los nuevos antivirales como el telaprevir, el rash cutá-neo aparecen en el 56% de los casos, si bien sólo el 1%-4% deben suspender el tratamiento por la gravedad de éste 2 .…”

Section: Discussionunclassified

Lesiones eccematosas de distribución generalizada

Barranco¹

2015

Sanid. Mil.

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CASO CLÍNICOVarón de 47 años de edad que consulta por presentar prurito intenso de la piel que desemboca en la aparición de una lesión eritematosa, de bordes vesiculosos e irregulares y superficie ligeramente escamosa en el brazo izquierdo y posteriormente aparecen lesiones semejantes en el resto del cuerpo incluyendo la cara. Unos meses antes inició tratamiento de una hepatitis C con 135mg de interferón alfa-2a semanalmente, administrado por vía subcutánea y ribavirina, 1.200 mg/día por vía oral.A la exploración presenta una placa eccematosa, pruriginosa, en el tercio inferior del brazo izquierdo. Ver figura. Se observan lesiones de características semejantes, de diversos tamaños que se distribuyen por los miembros inferiores y superiores, así como por el tó-rax, la cara y pabellones auriculares. El estado general del paciente es bueno, el hemograma y la bioquímica sanguínea son normales. Se practica una biopsia incisional del borde superior de la lesión ubicada en el brazo izquierdo. El laboratorio de anatomía patológica informa que se trata de una dermatitis psoriasiforme y espongiótica con formación de ampolla intracórnea con neutrófilos.Se establece el diagnóstico de eccema nummular generalizado secundario a la ingesta de interferón alfa-2a y ribavirina para el tratamiento de una hepatitis C. Tras consultar con el especialista Figura 1. Lesiones eccematosas tercio inferior del brazo izquierdo.

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High Prevalence of Cutaneous Reactions to Interferon Alfa Plus Ribavirin Combination Therapy in Patients With Chronic Hepatitis C Virus

Cited by 75 publications

References 3 publications

Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

Severe, Generalized Nummular Eczema Secondary to Interferon Alfa-2b Plus Ribavirin Combination Therapy in a Patient With Chronic Hepatitis C Virus Infection

Lesiones eccematosas de distribución generalizada

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