High prevalence of celiac disease in Brazilian blood donor volunteers based on screening by IgA antitissue transglutaminase antibody

Oliveira, Ricardo P.; Sdepanian, Vera Lúcia; Barreto, José Augusto; Cortez, Afonso José Pereira; Carvalho, Felipe Gonçalves de; Bordin, José Orlando; Soares, Maria Angélica de Camargo; Patrı́cio, Francy Reis da Silva; Kawakami, Elisabete; Morais, Mauro Batista de; Fagundes-Neto, Ulysses

doi:10.1097/01.meg.0000250586.61232.a3

Cited by 67 publications

(57 citation statements)

References 22 publications

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“…Therefore, serological tests accompanied by and duodenal biopsy are still mandatory to confirm the diagnosis of CD. Some Brazilian studies (3,7,10,11,24,26,27,28,37) showed high CD prevalence through the evaluation of the level of antitransglutaminase and duodenal biopsy, including 1:214 in São Paulo (26) , 1:273 in Riberão Preto (24) , 1:417 in Curitiba (27) and 1:681 in Brasilia (10) .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Genetic Susceptibility for Celiac Disease in Blood Donors in São Paulo, Brazil

Muniz

Sdepanian

Neto

2016

Arq. Gastroenterol.

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-Background -Celiac disease is a permanent intolerance induced by gluten, which is expressed by T-cell mediated enteropathy, and has a high prevalence in the general population. There is evidence of a strong genetic predisposition to celiac disease. Objective -To determine the prevalence of genetic markers HLA-DQ2 and HLA-DQ8 in blood donors from São Paulo and measure human recombinant tissue transglutaminase antibody IgA class in HLA-DQ2 and HLA-DQ8 positive donors.Methods -A total of 404 blood donors from São Paulo city and Jundiaí were included in the study and signed the informed consent form. Information regarding diarrhea, constipation and abdominal pain in the last 3 months was collected. Determination of HLADQ2 and HLADQ8 alleles was performed in all participants and human recombinant tissue transglutaminase antibody class IgA was measured only in blood donors who presentedDQ2 and/or DQ8. Results -HLADQ2 and/or HLADQ8 were positive in 49% (198/404) of subjects. Positive samples were associated with alleles DR3, DR4, DR7, DR11 and DR12. The most frequent genotype was DR4-DQ8, which was present in 13.6% of samples, followed by genotypes DR3-DQ2 and DR7-DQ2 with DQB1*02 in heterozygous, which were present in 10.4% and 8.7%, respectively. Eleven out of 198 positive donors (5%) were positive to human tissue transglutaminase test. Conclusion -We observed a high prevalence of genetic markers for celiac disease, HLA-DQ2 and HLA-DQ8, in blood donors from São Paulo, similar to prevalence described in Europe. These findings show that the prevalence of celiac disease should not be rare in our country, but underdiagnosed.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Genetic Susceptibility for Celiac Disease in Blood Donors in São Paulo, Brazil

Muniz

Sdepanian

Neto

2016

Arq. Gastroenterol.

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“…Several CD screening studies carried out during the last decade in Brazil have shown a prevalence of CD similar to that found in European countries, varying from 1:681 (0,14%) to 1:214 (0.46%) in presumably healthy blood donors (11,20,23,24,26) and from 0.34% to 0.84% in the general population (13,25) . In a previous survey performed with 2,629 girls and adult women at the same geographic area of this current study, it was found 8 females presenting biopsy-proven CD, corresponding to 0.34% prevalence (25) .…”

Section: Discussionmentioning

confidence: 66%

Screening for celiac disease among patients with Turner syndrome in Brasília, DF, midwest region of Brazil

Dias

Castro

Gandolfi

et al. 2010

Arq. Gastroenterol.

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-Context -Several studies have demonstrated a higher prevalence of celiac disease (CD) among females with Turner syndrome when compared to the general population. Nevertheless, there is no record in literature concerning this investigation among Brazilian patients. Objective -To assess the prevalence of CD among a group of Brazilian patients with Turner syndrome. Methods -Fifty-six females with Turner syndrome and on gluten-containing diet were screened for CD utilizing immunoglobulin A antiendomysium (IgA-EMA) and immunoglobulin A anti-tissue transglutaminase (IgA-tTG) antibody assays. Additionally, they were genotyped for CD human leukocyte antigen (CD-HLA) predisposing alleles. Patients showing positivity in serological testing were offered to perform small intestine biopsy for histological confirmation. Results -Mean age at diagnosis of Turner syndrome was 5.5 ± 4.4 years; mean age at screening for CD was 17.0 ± 9.3 years (from 10 months of age to 52 years). Two girls were positive for IgA-EMA and IgA-tTG, presented predisposing HLA-DQ2 alleles and both had the diagnosis of CD confirmed by jejunal biopsy. Conclusion -The 3.6% prevalence of biopsy-proven CD among this group of females with Turner syndrome is 10 times higher than the one among females from the general population of the same geographical area. This result provides additional support to an association between these two disorders and restates that girls and women with Turner syndrome represent a high risk population for developing CD.

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“…1). The prevalence of CD in children in northern India is 0.32%, in adults in Turkey it is 1.3%, in Argentina it is 0.6% and in Brazil it is between 0.15% and 0.46% [15,16]. The current prevalence of CD in Europe and the USA is 1-3% [16].…”

Section: Introductionmentioning

confidence: 98%

Shared genetics in coeliac disease and other immune-mediated diseases

Gutiérrez-Achury

Almeida

Wijmenga

2011

Journal of Internal Medicine

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High prevalence of celiac disease in Brazilian blood donor volunteers based on screening by IgA antitissue transglutaminase antibody

Abstract: The prevalence of celiac disease in Sao Paulo city is high and comparable to that observed in European countries. It is possible that in Brazil the prevalence of this disease had previously been underestimated.

Cited by 67 publications

References 22 publications

Prevalence of Genetic Susceptibility for Celiac Disease in Blood Donors in São Paulo, Brazil

Prevalence of Genetic Susceptibility for Celiac Disease in Blood Donors in São Paulo, Brazil

Screening for celiac disease among patients with Turner syndrome in Brasília, DF, midwest region of Brazil

Shared genetics in coeliac disease and other immune-mediated diseases

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