High Pretreatment Platelet-to-Albumin Ratio Predicts Poor Survival Results in Locally Advanced Nasopharyngeal Cancers Treated with Chemoradiotherapy

Abstract

In a lack of similar research, we assessed the prognostic utility of pretreatment platelet-to-albumin ratio (PAR) in locally advanced nasopharyngeal carcinoma (LANPC) patients managed with concurrent chemoradiotherapy (CCRT). Patients and Methods: Present retrospective analysis included a sum of 128 consecutively treated LANPC patients who underwent cisplatinum-based radical CCRT. Availability of an ideal pretreatment PAR cutoff that may stratify the study population into two cohorts with significantly distinct survival outcomes was sought by utilizing the receiver operating characteristic (ROC) curve analysis. The primary and secondary endpoints were overall survival (OS) and progression-free survival (PFS), respectively. Results: A rounded 5.2 [area under the curve (AUC): 68.9%; sensitivity: 67.4%; and specificity: 65.2%] value was identified as the ideal PAR cutoff that grouped patients into two gatherings [PAR≥5.2 (N=60) versus <5.2 (N=68)]. The median follow-up duration was 86.4 months (range: 9-147). Kaplan-Meier comparisons between the two PAR groups revealed significantly diminished median PFS (69.4 versus 106.8 months for PAR<5.2; P< 0.012) and OS (88.3 versus not reached yet for PAR<5.2; P= 0.023) for the PAR ≥ 5.2 group. The results of multivariate analyses affirmed the pretreatment PAR≥5.2 as an independent prognostic factor that indicates diminished PFS (P= 0.016) and OS (P= 0.019) together with the respective N 2-3 nodal stage (versus N 0-1 ; P<0.05 for PFS and OS, respectively) and weight loss >5% at past six months (≤5%; P<0.05 for PFS and OS, respectively). Conclusion:The results of the current retrospective analysis provided a robust and independent adverse prognostic value for pretreatment PAR ≥ 5.2 in terms of median and longterm PFS and OS outcomes in LA-NPC patients this patient group treated with conclusive CCRT.

Platelet-to-Albumin Ratio: A Novel IgA Nephropathy Prognosis Predictor

“…In addition to reflecting the nutritional status of the body, ALB is considered to be associated with inflammation ( 22 , 23 ). It is proposed that a new indicator PAR that combines the above two might be able to better reflect the body’s inflammatory state ( 24 ). Chronic inflammation undoubtedly participated in the pathogenesis and development of IgAN, and inflammatory mediators might damage the structure and function of the kidney tissue ( 25 ).…”

Predictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome

“…Moreover, PAR has the ability to accurately reflect the status of immune system, systemic inflammation, and nutritional status of the patient simultaneously after considering the individual functions of PLTs and ALB. 12 Additionally, past investigations on the prognostic worth of PAR showed that the preoperative PAR was significantly associated with the patients' prognoses in pancreatic adenocarcinomas and non-small cell lung carcinomas. 9,10 A few previous studies have reported all cases that occurred between April and October, 14,17 This is consistent with our conclusions, that after grouping by year and quarter, it can be observed that the main infection time distribution was primarily found in the second and third quarters (Figure 1).…”

“…6 A number of previous studies have reported that the pathogenesis of SFTS is related to abnormal immune response. 7,8 Moreover, additional recent findings have confirmed that platelet-albumin ratio (PAR) can be used as a potential marker of inflammation in patients, and can serve as a prognostic factor or progression indicator for a variety of diseases, [9][10][11][12] For instance, preoperative PAR has been found to be a useful and potential prognostic biomarker in patients with non-small cell lung cancer undergoing primary resection. 9 Preoperative PAR has also been described as a novel and effective independent prognostic indicator of survival after pancreatectomy.…”

“…Moreover, another report on the prognostic value of PAR has shown that preoperative PAR is closely associated with prognosis in patients with cholangiocarcinoma and liver cancer. 12 However, there is currently no report that has evaluated the possible role of PAR in SFTS. For this reason, we aimed to analyze the potential role of PAR in predicting the mortality in adult patients with SFTS in this study.…”

Clinical Impact of Platelet-to-albumin Ratio on Esophageal Cancer Patients Who Receive Curative Treatment

“…Recently, the platelet-to-albumin ratio (PAR) was developed and reported as a promising prognostic factor in gastrointestinal malignancies (11)(12)(13). Previous reports have shown that platelets are a marker of the systemic inflammation status, and albumin is one of the most important markers of nutritional status.…”