High performance TadA-8e derived cytosine and dual base editors with undetectable off-target effects in plants
Tingting Fan,
Yanhao Cheng,
Yuechao Wu
et al.
Abstract:Cytosine base editors (CBEs) and adenine base editors (ABEs) are powerful tools to install precise C-to-T and A-to-G base edits in living organisms. In recently years, a highly efficient ABE based on engineered TadA-8e, known as ABE8e, has been developed to confer highly efficient A-to-G editing in mammalian cells and plants. Interestingly, TadA-8e can be further evolved and engineered to confer cytosine base editing. In this study, we compare in rice and tomato cells a serial of engineered CBEs derived from T… Show more
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