High-performance liquid chromatographic analysis of bisphenol A and 4-nonylphenol in serum, liver and testis tissues after oral administration to rats and its application to toxicokinetic study

Xiao, Qi; Li, Yuanqian; Ouyang, Huaxue; Xu, Peiyu; Wu, Desheng

doi:10.1016/j.jchromb.2005.11.024

Cited by 65 publications

(42 citation statements)

References 28 publications

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“…Müller et al 17 assessed the kinetics of nonylphenol after oral and intravenous exposures among two healthy volunteers. The authors observed that the half-life of nonylphenol in blood was short (2–3 hours) after oral or intravenous application, in accordance with studies among rats,38 39 and that only 11.5% of the oral dose was recovered in the urine and faeces during the study. This could mean that the remainder may be exhaled or taken up by the lipid compartment, but the literature is too scarce to draw conclusions on the toxicokinetics of nonylphenol as well as of other alkylphenolic compounds 40…”

Section: Discussionsupporting

confidence: 75%

Job-exposure matrix for the assessment of alkylphenolic compounds

et al. 2016

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currently ~2300 cases and ~4200 controls), to study risk factors and possible gene-environment interactions; international pooling of case-control studies; using existing cohorts (e.g. EPIC) ; and aiming to register all Dutch ALS cases. Consistent positive associations between smoking and ALS were observed within PAN and EPIC, indicating that a similar approach for occupational risk factors would be informative. Because each study design has its advantages and disadvantages , neurodegenerative disorders should be looked at more in a range of (occupational) studies to gain better understanding of the aetiology.

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Section: Discussionsupporting

confidence: 75%

Job-exposure matrix for the assessment of alkylphenolic compounds

et al. 2016

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“…The samples were dissolved in 100 ml of high-performance liquid chromatography graded acetonitrile for injection to high-performance liquid chromatography for the analysis. 23,24 The retention time for BPA was 4.5 minutes (Figure 2). Recovery studies were performed on blank samples and the average recoveries were found to be 91 + 0.1% on 20 occasions.…”

Section: Bpa Measurementsmentioning

confidence: 99%

Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder

et al. 2015

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The aim of this study was to investigate the relationship between autism spectrum disorders development and exposure to mono-(2-ethylhexyl)-phthalate (MEHP), di-(2-ethylhexyl)-phthalate (DEHP), and bisphenol A (BPA), 1 of the endocrine disruptors, among phthalates. The study included 48 children with autism spectrum disorder (27 boys, 21 girls) and 41 healthy subjects (24 boys, 17 girls) as controls. Serum MEHP, DEHP, and BPA levels were measured by using high-performance liquid chromatography. Children with autism spectrum disorder had significantly increased serum MEHP, DEHP, and BPA concentrations (0.47 ± 0.14 µg/ml, 2.70 ± 0.90 µg/ml, 1.25 ± 0.30 ng/ml) compared to healthy control subjects (0.29 ± 0.05 µg/ml, 1.62 ± 0.56 µg/ml, 0.88 ± 0.18 ng/ml) respectively (P = .000). The fact that higher serum MEHP, DEHP, and BPA were found levels in the autism spectrum disorder group compared to healthy controls suggests that endocrine disruptors may have a role in the pathogenesis of autism spectrum disorders.

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“…Pretreatment of blood samples : The blood samples were pretreated according to a previously described method [15]. Subsequently, 1 m l serum was mixed with 200 µl potassium dihydrogen phosphate (1 M) and 8 m l methyl tertiary butyl ether.…”

Section: Methodsmentioning

confidence: 99%

Alkylphenol Polyethoxylate Derivatives in Groundwater and Blood Samples Collected from Pig Herds in Taiwan

Chiu

Hsieh

Miaw

et al. 2014

The Journal of Veterinary Medical Science

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Alkylphenol polyethoxylate (APEO) derivatives, such as nonylphenol monoethoxylate (NP1EO), nonylphenol diethoxylate (NP2EO), nonylphenol (NP) and octylphenol (OP), have been detected in the surface water, sediment, food and groundwater of numerous countries. Because groundwater is the main source of water for pig herds, the aim of this study was to measure the concentrations of APEO derivatives in groundwater and blood samples that were collected from pig herds raised near the Wuluo River in Southern Taiwan. The mean concentrations of NP, OP, NP1EO and NP2EO in the groundwater supply for 10 pig herds were 0.04 µg/l, 0.26 ± 0.23 µg/l, 0.74 ± 0.69 µg/l and 0.17 ± 0.22 µg/l, respectively. NP was detected in all blood samples collected from 5 of the 10 pig herds. The highest concentrations detected in the blood samples collected from six-week-old piglets and sows were 12.00 µg/l and 56.94 µg/l, respectively. Blood samples from 4 of the 5 herds showed OP contamination. The highest OP concentrations detected in 6-week-old piglets and sows were 275.58 µg/l and 566.32 µg/l, respectively. These results indicate that APEO derivatives accumulated in the groundwater supply and the bloodstreams of the pigs.

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High-performance liquid chromatographic analysis of bisphenol A and 4-nonylphenol in serum, liver and testis tissues after oral administration to rats and its application to toxicokinetic study

Cited by 65 publications

References 28 publications

Job-exposure matrix for the assessment of alkylphenolic compounds

Job-exposure matrix for the assessment of alkylphenolic compounds

Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder

Alkylphenol Polyethoxylate Derivatives in Groundwater and Blood Samples Collected from Pig Herds in Taiwan

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