High neutrophil to lymphocyte ratio is associated with white matter hyperintensity in a healthy population

Nam, Ki Woong; Kwon, Hyung‐Min; Jeong, Hawoong; Park, Jin Ho; Kim, Sang Hyuck; Jeong, Su Jin; Yoo, Taiwoo; Kim, Shinhye

doi:10.1016/j.jns.2017.07.024

Cited by 42 publications

(64 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…white matter microstructural damage or cerebral blood flow) were not ascertained, precluding evaluation of more subtle vascular measures. Future studies might examine relationships between neutrophil markers and vascular brain changes [58] either not present or not measured in ADNI 1 (e.g. WMH on FLAIR imaging, fractional anisotropy by diffusion tensor imaging, or cerebral blood flow by arterial spin labelling) as potential mediators of the relationship between neutrophil markers and executive decline.…”

Section: Discussionmentioning

confidence: 99%

A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild Alzheimer’s disease

Bawa

Krance

Herrmann

et al. 2020

J Neuroinflammation

View full text Add to dashboard Cite

Background: Studies suggest a role of the innate immune system, including the activity of neutrophils, in neurodegeneration related to Alzheimer's disease (AD), but prospective cognitive data remain lacking in humans. We aimed to investigate the predictive relationship between neutrophil-associated inflammatory proteins in peripheral blood and changes in memory and executive function over 1 year in patients with AD. Methods: Participants with AD were identified from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Neutrophil gelatinase-associated lipocalin (NGAL), myeloperoxidase (MPO), interleukin-8 (IL-8), macrophage inflammatory protein-1 beta (MIP-1β), and tumor necrosis factor (TNF) were assayed by luminex immunofluorescence multiplex assay at baseline. Confirmatory factor analysis was used to test an underlying neutrophil associated plasma inflammatory factor. Composite z-scores for memory and executive function were generated from multiple tests at baseline and at 1 year. A multiple linear regression model was used to investigate the association of the baseline inflammatory factor with changes in memory and executive function over 1 year. Results: Among AD patients (n = 109, age = 74.8 ± 8.1, 42% women, Mini Mental State Examination [MMSE] = 23.6 ± 1.9), the neutrophil-related inflammatory proteins NGAL (λ = 0.595, p < .001), MPO (λ = 0.575, p < .001), IL-8 (λ = 0.525, p < .001), MIP-1β (λ = 0.411, p = .008), and TNF (λ = 0.475, p < .001) were found to inform an underlying factor. Over 1 year, this inflammatory factor predicted a decline in executive function (β = − 0.152, p = 0.015) but not memory (β = 0.030, p = 0.577) in models controlling for demographics, brain atrophy, white matter hyperintensities, the ApoE ε4 allele, concomitant medications, and baseline cognitive performance.

show abstract

Section: Discussionmentioning

confidence: 99%

A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild Alzheimer’s disease

Bawa

Krance

Herrmann

et al. 2020

J Neuroinflammation

View full text Add to dashboard Cite

show abstract

“…Compared to manual results, computed semi‐automatically measured brain volume showed high agreement with an R 2 of 0.93 . This semi‐automated technique was widely used to measure WMH volume in many previous studies .…”

Section: Methodsmentioning

confidence: 71%

Favorable impact of non‐alcoholic fatty liver disease on the cerebral white matter hyperintensity in a neurologically healthy population

Jeong

Kwon

Park

et al. 2019

Euro J of Neurology

Self Cite

View full text Add to dashboard Cite

Background and purpose Although non‐alcoholic fatty liver disease (NAFLD) shares common cardiovascular risk factors with cerebral white matter hyperintensity (WMH), few studies have reported the association between NAFLD and WMH. The association between the presence of NAFLD with its severity and the volume of WMH was investigated. Methods This cross‐sectional study was conducted for 2460 subjects who voluntarily participated in health screening check‐ups including brain magnetic resonance imaging and liver ultrasonography at the Health Promotion Center at Seoul National University Hospital from 2009 to 2013. Ultrasonography was used to detect the presence and severity of NAFLD combined with the NAFLD fibrosis score and the FIB‐4 index. The volume of WMH was measured using a semi‐automated quantification method by a trained neurologist. Results The prevalence of NAFLD was 36.5%, and the median volume of WMH in all the subjects was 1.1 ml (interquartile range 0.2–2.7 ml). The presence of NAFLD was associated with a smaller volume of WMH [β (standard error, SE) −0.051 (0.046); P = 0.012]. Moderate to severe NAFLD was associated with a smaller volume of WMH than was non‐NAFLD [β (SE) −0.067 (0.061); P = 0.002]. The negative correlation observed between NAFLD severity and WMH volume was persistent only in those with low FIB‐4 index and low NAFLD fibrosis scores, whereas there was a positive association in those with high FIB‐4 index and NAFLD fibrosis scores. Conclusions Non‐alcoholic fatty liver disease, and its severity, showed a favorable association with WMH volume. However, its causality and mechanism should be evaluated in further relevantly designed studies.

show abstract

“…Finally, a higher NLR suggests a hostile environment, which is vulnerable to ischemic insult. The NLR might be a marker of subclinical inflammation that is related to chronic diseases, including various metabolic diseases, cardiovascular disease, cerebral small vessel diseases and atherosclerosis [ 28 , 34 – 36 ]. Patients with a higher NLR may be more vulnerable to ischemic insults and could have frequent END events.…”

Section: Discussionmentioning

confidence: 99%

“…The cell count analyses were performed with an autoanalyzer (XE-2100, Sysmex, Kobe, Japan) in our centers. The NLR was calculated as the ratio of the absolute neutrophil count over the absolute lymphocyte count (neutrophil count/lymphocyte count) [ 28 ]. Since this study also focused on the effects of temporal variations in the NLR on END, we obtained the NLRs from all participants during the following three periods to consider the temporal relationship between the NLR values and END: at admission (initial NLR), 1–3 days after admission just before END events (D 1–3 NLR), and 4–7 days after admission (D 4–7 NLR) (i.e., after END events).…”

Section: Methodsmentioning

confidence: 99%

Temporal changes in the neutrophil to lymphocyte ratio and the neurological progression in cryptogenic stroke with active cancer

Nam

Kim

et al. 2018

PLoS ONE

Self Cite

View full text Add to dashboard Cite

BackgroundIschemic stroke patients with active cancer frequently experience early neurological deterioration (END); however, the predictors of END are not well studied. The neutrophil to lymphocyte ratio (NLR) has recently been described as a predictor of poor outcomes in cancer and stroke. However, its role in cancer-related stroke has not been addressed.AimWe aimed to evaluate the association between the NLR and END in cancer-related stroke patients.MethodsWe included 85 cryptogenic stroke patients with active cancer. END was defined as an increase ≥ 4 on the total National Institutes of Health Stroke Scale (NIHSS) score within 72 hours of admission. The NLR was calculated as the ratio of the absolute neutrophil count to the absolute lymphocyte count. We obtained the NLR during the following three periods: at admission, 1–3 days after admission (D 1–3 NLR) and 4–7 days after admission (D 4–7 NLR).ResultsEND occurred in 15 (18%) of the 85 patients. END was significantly associated with the initial NIHSS score, infarction volume, and the D 1–3 NLR. In multivariate analysis, a higher D 1–3 NLR, measured before END events, remained an independent predictor of END [adjusted odds ratio = 2.78, 95% confidence interval = 1.09–7.08, P = 0.032]. In terms of temporal changes in the NLR, the END group showed a tendency toward temporal increase in the NLR at D 1–3 (P = 0.061) with subsequent decrements in the D 4–7 NLR (P = 0.088), while the non-END group showed no significant changes in the NLR between periods.ConclusionsThis study demonstrated that a higher NLR could predict END events in cryptogenic stroke patients with active cancer. However, the results should be confirmed in further large prospective studies.

show abstract

High neutrophil to lymphocyte ratio is associated with white matter hyperintensity in a healthy population

Cited by 42 publications

References 30 publications

A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild Alzheimer’s disease

A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild Alzheimer’s disease

Favorable impact of non‐alcoholic fatty liver disease on the cerebral white matter hyperintensity in a neurologically healthy population

Temporal changes in the neutrophil to lymphocyte ratio and the neurological progression in cryptogenic stroke with active cancer

Contact Info

Product

Resources

About