High-Meat-Protein High-Fat Diet Induced Dysbiosis of Gut Microbiota and Tryptophan Metabolism in Wistar Rats

Shi, Jie; Zhao, Di; Song, Shangxin; Zhang, Miao; Zamaratskaia, Galia; Xu, Xinglian

doi:10.1021/acs.jafc.0c00245

Cited by 54 publications

(49 citation statements)

References 59 publications

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“…Meanwhile, taxa of two predominantly butyrate-producing genus, Faecalibacterium and Ruminococcus, are also reported significantly more prevalent in obese individuals than in non-obese individuals (Maniar et al, 2019). As shown in the cecum and colon of rats (Shi et al, 2020), the increase in the Family XIII AD3011 group may be involved in the production of skatole and indole. Moreover, the families Lachnospiraceae, Clostridia, and Ruminococcaceae, and genera Ruminiclostridium, Blautia, and Butyrivibrio, have been suggested as high fat diet-dependent gut taxa and are likely associated with lipid metabolism (Lin et al, 2016;Zietak et al, 2016;Kong et al, 2019;Hou et al, 2020).…”

Section: Discussionmentioning

confidence: 89%

Specific Microbial Taxa and Functional Capacity Contribute to Chicken Abdominal Fat Deposition

Xiang

Gan²,

Zeng

et al. 2021

Front. Microbiol.

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Genetically selected chickens with better growth and early maturation show an incidental increase in abdominal fat deposition (AFD). Accumulating evidence reveals a strong association between gut microbiota and adiposity. However, studies focusing on the role of gut microbiota in chicken obesity in conventional breeds are limited. Therefore, 400 random broilers with different levels of AFD were used to investigate the gut microbial taxa related to AFD by 16S rRNA gene sequencing of 76 representative samples, and to identify the specific microbial taxa contributing to fat-related metabolism using shotgun metagenomic analyses of eight high and low AFD chickens. The results demonstrated that the richness and diversity of the gut microbiota decrease as the accumulation of chicken abdominal fat increases. The decrease of Bacteroidetes and the increase of Firmicutes were correlated with the accumulation of chicken AFD. The Bacteroidetes phylum, including the genera Bacteroides, Parabacteroides, and the species, B. salanitronis, B. fragilis, and P. distasonis, were correlated to alleviate obesity by producing secondary metabolites. Several genera of Firmicutes phylum with circulating lipoprotein lipase activity were linked to the accumulation of chicken body fat. Moreover, the genera, Olsenella and Slackia, might positively contribute to fat and energy metabolism, whereas the genus, Methanobrevibacter, was possible to enhance energy capture, and associated to accumulate chicken AFD. These findings provide insights into the roles of the gut microbiota in complex traits and contribute to the development of effective therapies for the reduction of chicken fat accumulation.

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Section: Discussionmentioning

confidence: 89%

Specific Microbial Taxa and Functional Capacity Contribute to Chicken Abdominal Fat Deposition

Xiang

Gan²,

Zeng

et al. 2021

Front. Microbiol.

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“…On the other hand, Prevotella 9 , Dialister , Faecalibacterium , Megamonas , and Prevotella 2 were more abundant in the feces of chicken-eaters. Such a difference could be attributed to dietary structure that is more complex than a strictly controlled diet in our previous rat study 13 . In that study, chicken and pork protein diets increased the abundance of Lactobacillus , the Family XIII AD3011 group , and Desulfovibrio in rat large intestine relating to the production of skatole and indole 13 .…”

Section: Discussionmentioning

confidence: 83%

“…Many studies have been focused on the effects of meat consumption on the composition of gut microbiota, however, only few studies investigated an impact of meat consumption on tryptophan metabolites. In a previous study, we found that a high fat high chicken or pork protein diet increased the abundance of gut microbiota associated with skatole and indole production in Wistar rats 13 . In the present study, we investigated the differences in composition of gut microbiota, tryptophan metabolites and SCFAs in feces in volunteers who frequently consume chicken or pork products.…”

Section: Introductionmentioning

confidence: 82%

“…Preferences for meat type differ between consumers. In a rat study with strict design, we observed that high meat protein diets caused the dysbiosis of gut microbiota and tryptophan metabolism 13 . In the present study, we for the first time investigated the gut microbiota and tryptophan metabolism in volunteers who frequently eat chicken or pork products.…”

Section: Discussionmentioning

confidence: 99%

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Chicken-eaters and pork-eaters have different gut microbiota and tryptophan metabolites

Shi

Zhao

Fan

et al. 2021

Sci Rep

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This study was aimed to evaluate the differences in the composition of gut microbiota, tryptophan metabolites and short-chain fatty acids in feces between volunteers who frequently ate chicken and who frequently ate pork. Twenty male chicken-eaters and 20 male pork-eaters of 18 and 30 years old were recruited to collect feces samples for analyses of gut microbiota composition, short-chain fatty acids and tryptophan metabolites. Chicken-eaters had more diverse gut microbiota and higher abundance of Prevotella 9, Dialister, Faecalibacterium, Megamonas, and Prevotella 2. However, pork-eaters had higher relative abundance of Bacteroides, Faecalibacterium, Roseburia, Dialister, and Ruminococcus 2. In addition, chicken-eaters had high contents of skatole and indole in feces than pork-eaters, as well as higher contents of total short chain fatty acids, in particular for acetic acid, propionic acid, and branched chain fatty acids. The Spearman’s correlation analysis revealed that the abundance of Prevotella 2 and Prevotella 9 was positively correlated with levels of fecal skatole, indole and short-chain fatty acids. Thus, intake of chicken diet may increase the risk of skatole- and indole-induced diseases by altering gut microbiota.

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“…However, HPD showed a reduction in fecal butyrate concentration in a repetitive manner. The intake of high-fat and high-protein diets can lead to a dysfunction in the intestinal microbiota; its metabolite biosynthesis may lead to an imbalance, which subsequently causes intestinal inflammation that may further lead to IBD ( Shi et al., 2020 ). Caspase recruitment domain-containing protein 9 is one among many IBD-susceptible genes, promoting the recovery of colitis by activating the interleukin-22 pathway ( Lamas et al., 2016 ).…”

Section: Protein/amino Acid Metabolites In the Progression Of Gastrointestinal Diseasesmentioning

confidence: 99%

Mutual interaction between gut microbiota and protein/amino acid metabolism for host mucosal immunity and health

Tang

Chen

et al. 2021

Animal Nutrition

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In recent years, many studies have shown that the intestinal microflora has various effects that are linked to the critical physiological functions and pathological systems of the host. The intestinal microbial community is widely involved in the metabolism of food components such as protein, which is one of the essential nutrients in diets. Additionally, dietary protein/amino acids have been shown to have had a profound impact on profile and operation of gut microbiota. This review summarizes the current literature on the mutual interaction between intestinal microbiota and protein/amino acid metabolism for host mucosal immunity and health.

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High-Meat-Protein High-Fat Diet Induced Dysbiosis of Gut Microbiota and Tryptophan Metabolism in Wistar Rats

Cited by 54 publications

References 59 publications

Specific Microbial Taxa and Functional Capacity Contribute to Chicken Abdominal Fat Deposition

Specific Microbial Taxa and Functional Capacity Contribute to Chicken Abdominal Fat Deposition

Chicken-eaters and pork-eaters have different gut microbiota and tryptophan metabolites

Mutual interaction between gut microbiota and protein/amino acid metabolism for host mucosal immunity and health

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