2008
DOI: 10.1111/j.1440-1843.2007.01212.x
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Abstract: These results suggest that with advancing stage of lung cancer, the levels of oxidative stress increase, while levels of antioxidant molecules decrease. Patients with squamous cell carcinoma have higher oxidative stress as reflected by higher levels of malondialdehyde and nitrite.

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Cited by 104 publications
(88 citation statements)
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“…Recent studies showed that increased levels of oxidative stress were observed in subjects with lung cancer when compared with healthy controls. 42 The oxidative stress causes oxidation in the guanine base in DNA, which results in the production of 8-oxo-7,8-dihydro-2Ј-deoxyguanosine. 43 Moreover, guanine base oxidations cause G to T transversion mutations in DNA, which are found in the K-ras oncogene and p53 tumor-suppressor gene of human lung cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies showed that increased levels of oxidative stress were observed in subjects with lung cancer when compared with healthy controls. 42 The oxidative stress causes oxidation in the guanine base in DNA, which results in the production of 8-oxo-7,8-dihydro-2Ј-deoxyguanosine. 43 Moreover, guanine base oxidations cause G to T transversion mutations in DNA, which are found in the K-ras oncogene and p53 tumor-suppressor gene of human lung cancer.…”
Section: Discussionmentioning
confidence: 99%
“…More recently, patients with advanced LC exhibited increased systemic oxidative stress levels compared to healthy controls (18,33). In a previous study from our group (25), protein carbonylation levels, as measured by malondialdehyde (MDA)-protein adducts, were also increased in the normal epithelium of patients with LC, especially in patients with underlying COPD, whose levels were significantly greater than in those without this disease.…”
Section: Redox Balancementioning
confidence: 86%
“…Oxidative stress, defined as the imbalance between oxidants and antioxidants in favor of the former, represents another relevant contributing factor to LC progression (18)(19)(20)(21)(22)(25)(26)(27)(28)33,36) ( Figure 3). Oxidative and nitrosative stress were shown to favor carcinogenesis through the activation of cellular processes that result in neoplastic transformation, the induction of DNA mutations (32,114), or even through induction of macrophage dysfunction (alterations in phagocytosis) (27).…”
Section: Redox Balancementioning
confidence: 99%
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