2018
DOI: 10.1186/s13071-018-3069-0
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High levels of human infection with Trypanosoma cruzi associated with the domestic density of infected vectors and hosts in a rural area of northeastern Argentina

Abstract: BackgroundInsecticide spraying campaigns designed to suppress the principal vectors of the Chagas disease usually lack an active surveillance system that copes with house reinvasion. Following an insecticide campaign with no subsequent surveillance over a 12-year period, we implemented a longitudinal intervention programme including periodic surveys for Triatoma infestans, full-coverage house spraying with insecticides, and selective control in a well-defined rural area of the Argentinean Chaco inhabited by Cr… Show more

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Cited by 27 publications
(55 citation statements)
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“…To this end, we used the abundance of T. cruzi -infected vectors because it is more closely related to the prevalence and incidence of human infection with T. cruzi [30, 32, 33, 62] than other indices, but the main outcomes with other indices (domiciliary infestation and vector abundance) were qualitatively congruent. In adjacent rural communities the relative risk of human infection increased almost three times with every infected vector collected in the domicile [26]. Households with both greater social vulnerability and host availability had the highest abundance of infected vectors, corroborating the occurrence of between- and within-group variations in transmission risks.…”
Section: Discussionmentioning
confidence: 88%
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“…To this end, we used the abundance of T. cruzi -infected vectors because it is more closely related to the prevalence and incidence of human infection with T. cruzi [30, 32, 33, 62] than other indices, but the main outcomes with other indices (domiciliary infestation and vector abundance) were qualitatively congruent. In adjacent rural communities the relative risk of human infection increased almost three times with every infected vector collected in the domicile [26]. Households with both greater social vulnerability and host availability had the highest abundance of infected vectors, corroborating the occurrence of between- and within-group variations in transmission risks.…”
Section: Discussionmentioning
confidence: 88%
“…The present study stems from a broader long-term research programme on the eco-epidemiology and control of Chagas disease in the municipality of Pampa del Indio, a highly endemic, mostly rural area of the Argentine Chaco where creoles and an indigenous people (Qom) live in structural poverty. In this region the seroprevalence of T. cruzi in indigenous peoples tends to exceed that of creoles [18–26]. Particularly in Pampa del Indio, house infestation rates with the main vector of Chagas disease, Triatoma infestans , were higher in Qom than in creole households [2729] and dogs and cats from Qom households exhibited a higher T. cruzi- infection prevalence than those owned by creoles [30].…”
Section: Introductionmentioning
confidence: 99%
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“…The Gran Chaco has the highest prevalence of CD in the world [50]. Despite the presence of insecticide spraying campaigns in the last 15 years in this region, T. cruzi prevalence remains extraordinarily high, with close to universal infection among adults over 30 years-old [15, 49, 59, 60]. In this region T. infestans , T. sordida and T. guasayana have been shown to infest houses [61, 62] and sylvatic populations of these tree species have been described [56, 57, 6365].…”
Section: Methodsmentioning
confidence: 99%
“…Canine Chagas disease. Dogs are important in peridomestic cycles in Latin America, both as vector blood meal sources and T. cruzi infection reservoirs (85,86). In the hyperendemic Chaco region of Argentina, dogs have been shown to be highly infective to vectors and are thought to be a key reservoir sustaining transmission to humans (87).…”
Section: Wild and Domestic Animal Reservoirsmentioning
confidence: 99%