volume 66, issue 9, P5492-5499 1992
DOI: 10.1128/jvi.66.9.5492-5499.1992
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W L Marshall, D C Diamond, M M Kowalski, R W Finberg

Abstract: CD4 is the principal receptor for the human immunodeficiency virus (HIV). We have isolated and studied CD4-expressing tumor cell clones made by expressing CD4 in the T-cell tumor line HSB. Two clones, one designated HSBCD4, a clone expressing low levels of CD4, and the other, HSB10xCD4, a high-expresser CD4+ clone, were studied for their ability to bind and replicate HIV. In contrast to many other CD4+ cells that down-modulate CD4 following HIV infection, the HSB10XCD4 clones continued to express high levels o…

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