High intratumoural but not peritumoural inflammatory host response is associated with better prognosis in primary resected oesophageal adenocarcinomas

Stein, Alexandra; Dislich, Bastian; Blank, Annika; Guldener, Lars; Kröll, Dino; Seiler, Christian; Langer, Rupert

doi:10.1016/j.pathol.2016.10.005

Cited by 29 publications

(45 citation statements)

References 41 publications

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“…Five articles, including 732 patients, investigated the association between generalized TILs and the survival of patients with EC [27, 29, 33, 34, 36]. Four articles evaluated patients’ OS [29, 33, 34, 36], and the pooled results showed that patients with high level of generalized TILs had better OS (pooled HR = 0.48; 95% CI = 0.38-0.61; P < 0.001) (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Four articles evaluated patients’ OS [29, 33, 34, 36], and the pooled results showed that patients with high level of generalized TILs had better OS (pooled HR = 0.48; 95% CI = 0.38-0.61; P < 0.001) (Table 2). Besides, one article evaluated patients’ DFS (HR = 1.77, 95% CI = 1.17-2.69, P = 0.007) [27], and one article evaluated patients’ CSS (HR = 0.51, 95% CI = 0.35-0.75, P = 0.001) [34].…”

Section: Resultsmentioning

confidence: 99%

“…A total of 16 articles, including 2121 patients, investigated the prognostic value of CD8 + TILs in patients with EC [11-14, 24, 25, 28, 30-33, 35, 37-40]. Thirteen articles evaluated patients’ OS [11, 12, 24, 28, 30-33, 35, 37-40].…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen articles evaluated patients’ OS [11, 12, 24, 28, 30-33, 35, 37-40]. The pooled results showed that patients with high level of CD8 + TILs had better OS (pooled HR = 0.68; 95% CI = 0.56-0.84; P < 0.001) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Seven articles, including 906 tumor patients, investigated the prognostic value of FoxP3 + TILs in patients with EC [13, 14, 24, 33, 37, 39, 40]. Five articles evaluated patients’ OS [24, 33, 37, 39, 40].…”

Section: Resultsmentioning

confidence: 99%

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Prognostic Role of Tumor-Infiltrating Lymphocytes in Esophagus Cancer: a Meta-Analysis

Zheng¹,

Song

Shao

et al. 2018

Cell Physiol Biochem

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Background/Aims: Several studies have verified the correlation between tumor-infiltrating lymphocytes (TILs) and survival of patients with esophagus cancer (EC). However, the prognostic role of TILs is still controversial. Therefore, we performed this meta-analysis. Methods: We searched PubMed, Embase and the Cochrane Library (last update by August 30, 2017) to identify studies assessing the effect of TILs on survival of patients with EC. Pooled hazard ratios (HRs) for overall survival (OS), disease-free survival (DFS) and cancer specific survival (CSS) were estimated using fixed-effects models or random-effects models, which depends on the heterogeneity. Results: Data from 22 observational studies including 2909 patients were summarized. Pooled analysis indicated that generalized TILs were favorable prognostic markers for OS in patients with EC (pooled HR = 0.48; 95% CI = 0.38-0.61; P < 0.001). For TIL subsets, CD8⁺ TILs were associated with improved OS (pooled HR = 0.68; 95% CI = 0.58–0.84; P < 0.001) and DFS (pooled HR = 0.90; 95% CI = 0.85-0.95; P < 0.001); FoxP3⁺ TILs were associated with patients’ DFS (pooled HR = 0.88; 95% CI = 0.81-0.96; P = 0.003). High CD57⁺ TILs indicated a better OS in patients with EC (pooled HR = 0.50; 95% CI = 0.35-0.72; P < 0.001). In addition, the pooled results showed that other TIL subsets including CD3⁺, CD4⁺ and CD45RO⁺ TILs were not associated with patients’ survival (P > 0.05). Conclusions: For patients with EC, some TIL subsets could serve as prognostic biomarkers. The application of TILs in the immunotherapy of EC needs to be verified through a large amount of clinical research.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic Role of Tumor-Infiltrating Lymphocytes in Esophagus Cancer: a Meta-Analysis

Zheng¹,

Song

Shao

et al. 2018

Cell Physiol Biochem

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Application of Tissue Microarray in Esophageal Adenocarcinoma

Saremi

Lam

2018

Methods in Molecular Biology

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Tissue microarray technology could allow immunohistochemical staining or in situ hybridization on hundreds of different tissue samples simultaneously. It allows faster analysis and considerably reducing costs incurred in staining. The technique also provides a high-throughput analysis of multiple tissues for the different types of research. In the literature, many researches of esophageal adenocarcinoma use tissue microarray to enhance the output. In this chapter, we have a brief overview of tissue microarray technologies, the advantages and disadvantages of tissue microarray, and related troubleshootings.

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Expression patterns of programmed death-ligand 1 in esophageal adenocarcinomas: comparison between primary tumors and metastases

Dislich

Stein

Seiler

et al. 2017

Cancer Immunol Immunother

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Expression analysis of programmed death-ligand 1 (PD-L1) may be helpful in guiding clinical decisions for immune checkpoint inhibition therapy, but testing by immunohistochemistry may be hampered by heterogeneous staining patterns within tumors and expression changes during metastatic course. PD-L1 expression (clone SP142) was investigated in esophageal adenocarcinomas using tissue microarrays (TMA) from 112 primary resected tumors, preoperative biopsies and full slide sections from a subset of these cases (n = 24), corresponding lymph node (n = 55) and distant metastases (n = 17). PD-L1 expression was scored as 0.1-1, >1, >5, >50% positive membranous staining of tumor cells and any positive staining of tumor-associated inflammatory infiltrates and/or stroma cells. There was a significant correlation with overall PD-L1 expression between the full slide sections and the TMA (p = 0.001), but not with the corresponding biopsies. PD-L1 expression in tumor cells >1% was detected in 8.0% of cases (9/112) and 51.8% of cases (58/112) in tumor-associated inflammatory infiltrates and/or stroma cells of primary tumors. Epithelial expression in metastases was found in 5.6% of cases (4/72) and immune cell expression in 18.1% of cases (13/72), but did not correlate with the expression pattern in the primary tumor. Overall PD-L1 expression in the primary tumor did not influence survival. However, PD-L1 expression was correlated with the number of CD3 tumor-infiltrating lymphocytes in the tumor center, and a combinational score of PD-L1 status/CD3 tumor-infiltrating lymphocytes was correlated with patients' overall survival.

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High intratumoural but not peritumoural inflammatory host response is associated with better prognosis in primary resected oesophageal adenocarcinomas

Cited by 29 publications

References 41 publications

Prognostic Role of Tumor-Infiltrating Lymphocytes in Esophagus Cancer: a Meta-Analysis

Prognostic Role of Tumor-Infiltrating Lymphocytes in Esophagus Cancer: a Meta-Analysis

Application of Tissue Microarray in Esophageal Adenocarcinoma

Expression patterns of programmed death-ligand 1 in esophageal adenocarcinomas: comparison between primary tumors and metastases

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