High-intensity training following lung cancer surgery: a randomised controlled trial

Edvardsen, Elisabeth; Skjønsberg, Ole Henning; Holme, Ingar; Nordsletten, Lars; Borchsenius, Fredrik; Anderssen, Sigmund Alfred

doi:10.1136/thoraxjnl-2014-205944

Cited by 154 publications

(219 citation statements)

References 37 publications

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“…The beneficial effects of rehabilitation in lung cancer patients, were currently limited to a few randomised trials. These trials showed that patients with lung cancer can improve their exercise capacity, muscle strength and QoL, however the results were not consistent [2,9,29].…”

Section: Introductionmentioning

confidence: 99%

Rehabilitation in patients with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities

et al. 2015

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a b s t r a c tIntroduction: The evidence on the effectiveness of rehabilitation in lung cancer patients is limited. Whole body vibration (WBV) has been proposed as an alternative to conventional resistance training (CRT). Methods: We investigated the effect of radical treatment (RT) and of two rehabilitation programmes in lung cancer patients. The primary endpoint was a change in 6-min walking distance (6MWD) after rehabilitation. Patients were randomised after RT to either CRT, WBVT or standard follow-up (CON). Patients were evaluated before, after RT and after 12 weeks of intervention. Results: Of 121 included patients, 70 were randomised to either CON (24), CRT (24) or WBVT (22). After RT, 6MWD decreased with a mean of 38 m (95% CI 22-54) and increased with a mean of 95 m (95% CI 58-132) in CRT (p < 0.0001), 37 m (95% CI −1-76) in WBVT (p = 0.06) and 1 m (95% CI −34-36) in CON (p = 0.95), respectively. Surgical treatment, magnitude of decrease in 6MWD by RT and allocation to either CRT or WBVT were prognostic for reaching the minimally clinically important difference of 54 m increase in 6MWD after intervention. Conclusions: RT of lung cancer significantly impairs patients' exercise capacity. CRT significantly improves and restores functional exercise capacity, whereas WBVT does not fully substitute for CRT.

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Section: Introductionmentioning

confidence: 99%

Rehabilitation in patients with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities

et al. 2015

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“…[8][9][10] Further, there have been some randomized controlled trials, and a recent Cochrane review, that have investigated whether this impairment in exercise capacity can be ameliorated with exercise training. [11][12][13] Although there is interest in exercise capacity and the role of exercise training in this population, data exploring the responses to exercise in people following curative intent treatment for NSCLC are scarce. The cardiopulmonary exercise test (CPET) is a laboratory-based assessment, which provides a global assessment of an individuals' response to exercise.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the six-minute walk test with a cycle-based cardiopulmonary exercise test in people following curative intent treatment for non-small cell lung cancer

et al. 2016

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This study is aimed to (i) compare both the magnitude of impairment in exercise capacity and exercise responses measured during the six-minute walk test (6MWT) and the cardiopulmonary exercise test (CPET) and (ii) investigate the effect of test repetition on six-minute walk distance (6MWD) in people following curative intent treatment for non-small cell lung cancer (NSCLC). Twenty participants (67 + 10 years; 14 females), 6-10 weeks following lobectomy, underwent a CPET and two 6MWTs. Peak exercise responses, dyspnoea and leg fatigue, as well as heart rate (HR) and oxygen saturation (SpO 2 ) during the 6MWT, were compared to those during the CPET. Compared with exercise capacity when expressed as peak rate of oxygen consumption (%pred) measured during the CPET, exercise capacity when expressed as 6MWD (%pred) was less impaired (81 + 10 vs. 63 + 15 %pred; p < 0.001). Compared with the CPET, the 6MWT elicited lower peak HR (119 + 15 vs. 128 + 18 beats minute À1; p ¼ 0.02), lower SpO 2 (93 + 2 vs. 95 + 3%; p < 0.05), less dyspnoea (3.1 + 1.6 vs. 6.9 + 2.6; p < 0.01) and less leg fatigue (2.0 + 1.9 vs. 6.8 + 2.4; p < 0.01). The 6MWD increased 19 + 19 metre (4 + 4%) with test repetition (p < 0.001). In people following curative intent treatment for NSCLC, the 6MWT appears to elicit sub-maximal exercise responses when compared with the CPET. There is a significant effect of test repetition on 6MWD.

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“…A randomised controlled trial published in 2014, on patients who underwent lung cancer surgery employed high-intensity endurance and strength training (60 min, three times a week, 20 weeks), starting 5e7 weeks after surgery in the intervention group and found that it was well tolerated and led to significant improvements in peak oxygen uptake muscular strength, total muscle mass, functional fitness and quality of life. 19 The exercise regime employed in this study was longer in duration and higher in intensity as that in our study, but it is difficult to directly compare the two study groups. But it is safe to say that aerobic exercise whether done preoperatively or postoperatively plays some role in reduction of PPC and LOS.…”

Section: Discussionmentioning

confidence: 99%

Postoperative exercise training is associated with reduced respiratory infection rates and early discharge: A case-control study

et al. 2017

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Available online xxxResults: The rate of RTI was only 16.6% in the exercise group and 43.3% in the control group (P ¼ 0.024). None of the cases or controls suffered from a DVT or PE. Median postoperative length of stay in the control group was 11 ± 7.5 days whereas in the cases it was 8.5 ± 5.00 days (P ¼ 0.049). The Borg subjective breathlessness score in the cases group showed a decline in the subjective breathlessness on postoperative day 4 (P ¼ 0.002).Conclusions: Early aerobic activity with a pedal exerciser halves the rate of postoperative RTI and postoperative hospital stay after complex abdominal surgery. Subjective breathlessness was also reduced with the use of pedal exerciser, signifying potential to improve exercise endurance in the postoperative patient.

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High-intensity training following lung cancer surgery: a randomised controlled trial

Abstract: NCT01748981.

Cited by 154 publications

References 37 publications

Rehabilitation in patients with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities

Rehabilitation in patients with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities

Comparison of the six-minute walk test with a cycle-based cardiopulmonary exercise test in people following curative intent treatment for non-small cell lung cancer

Postoperative exercise training is associated with reduced respiratory infection rates and early discharge: A case-control study

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