High-intensity resistance training in multiple sclerosis — An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle strength, walking and cognition

Kierkegaard, Marie; Lundberg, Ingrid E.; Olsson, Tomas; Johansson, Sverker; Ygberg, Sofia; Opava, Christina H.; Holmqvist, Lotta Widén; Piehl, Fredrik

doi:10.1016/j.jns.2016.01.063

Cited by 65 publications

(71 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One of these was a cohort study that used a post-hoc correlational design [26]. Table 2 shows the remaining 10 studies with experimental designs: two single-group, pretest-posttest designs [29,30], three randomized counterbalanced treatment designs [31–33], one randomized prospective study [ 34], and four RCTs [35–38]. …”

Section: Resultsmentioning

confidence: 99%

“…Exercise session length ranged from 30 to 90 min, and the frequency of sessions varied from once to three times a week. Exercise intensity (% of heart rate reserve or one repetition maximum, 1RM) was defined in four studies [30–33]. …”

Section: Resultsmentioning

confidence: 99%

“…The SDMT was used as a single measure of processing speed in five of the studies [21,28,30,35,38]. Several types of memory (e.g., episodic, relational, working, retrospective, and prospective) were evaluated in nine of the studies [20–23,28,30,35–37] using instruments specific to the type of memory under investigation. Six studies examined executive functioning [26,31–35].…”

Section: Resultsmentioning

confidence: 99%

“…Cognitive function was measured as the primary outcome in eight of the 10 intervention studies [30–36,38]. Two studies [29,37] were not specifically aimed at investigating cognitive outcomes but did include PASAT scores as a consequence of using the Multiple Sclerosis Functional Composite (MSFC) [49] to quantify MS-related functional impairment.…”

Section: Resultsmentioning

confidence: 99%

“…Notably, only four recently published papers documented the intensity of the exercise that participants did. [30–33] Sandroff and colleagues [31–33] have conducted a series of studies investigating the immediate (acute) effect of exercise on executive function. In those studies, treadmill walking yielded robust effects on executive control in ambulatory adults with MS, even in participants whose MS symptoms were worsened by increased body temperature (thermosensitivity).…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Physical activity and cognitive function in adults with multiple sclerosis: an integrative review

Morrison

Mayer

2016

Disability and Rehabilitation

View full text Add to dashboard Cite

Purpose To identify and synthesize the research evidence concerning (1) the relationship between physical activity and cognitive performance in persons with multiple sclerosis (MS) and (2) to review the reported effects of physical activity interventions on neurocognitive performance conducted in this population. Methods Relevant peer-reviewed journal articles were identified by searching PubMed, PsychINFO, and SPORTDiscus through May 2016. Full-text articles meeting the inclusion criteria were evaluated for quality using tools developed by the National Institutes of Health. Studies deemed to be of poor quality were excluded from the review. Results Nineteen studies meeting the inclusion/exclusion criteria were analyzed. Nine studies reported significant relationships between higher levels of physical activity or cardiorespiratory fitness and measures of cognitive function. Data extracted from 10 physical activity intervention studies reported mixed results on the effectiveness of physical activity to improve selected domains of cognitive function in persons with MS. Conclusion Although correlational studies provide evidence to support a linkage between physical activity and cognitive function in persons with MS, this linkage is confounded by factors that may have influenced the studies’ results. Evidence derived from intervention studies that could support a positive effect of physical activity on cognition in persons with MS is equivocal.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Physical activity and cognitive function in adults with multiple sclerosis: an integrative review

Morrison

Mayer

2016

Disability and Rehabilitation

View full text Add to dashboard Cite

show abstract

Exercise in multiple sclerosis and its models: Focus on the central nervous system outcomes

Guo

Lozinski

Yong

2019

J of Neuroscience Research

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a central nervous system (CNS) disorder characterized by inflammation, demyelination, and neurodegeneration. Emerging research suggests that exercise has therapeutic benefits for MS patients but the clinical data have focused primarily on non‐CNS outcomes. In this review, we discuss evidence in preclinical MS models that exercise influences oligodendrocyte proliferation and repopulation, remyelination, neuroinflammation, neuroprotection, axonal regeneration, and astrogliosis. Evidence for the therapeutic effects of exercise in MS is further supplemented by data from other CNS diseases, including Alzheimer's disease, Parkinson's disease, and spinal cord injury. These results motivate studies into the benefits that exercise confers within the CNS in MS.

show abstract

Physical exercise in myasthenia gravis is safe and improves neuromuscular parameters and physical performance-based measures: A pilot study

et al. 2017

View full text Add to dashboard Cite

show abstract

High-intensity resistance training in multiple sclerosis — An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle strength, walking and cognition

Cited by 65 publications

References 37 publications

Physical activity and cognitive function in adults with multiple sclerosis: an integrative review

Physical activity and cognitive function in adults with multiple sclerosis: an integrative review

Exercise in multiple sclerosis and its models: Focus on the central nervous system outcomes

Physical exercise in myasthenia gravis is safe and improves neuromuscular parameters and physical performance-based measures: A pilot study

Contact Info

Product

Resources

About