High incidence of minimal change nephrotic syndrome in Asians.

Feehally, John; Kendell, N P; Swift, P G; Walls, Joseph T.

doi:10.1136/adc.60.11.1018

Cited by 61 publications

(46 citation statements)

References 4 publications

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“…The Leicester Royal Infirmary admits children from the whole of Leicestershire, with a population under 16 years of 209,000, and there is a large Asian population known to have a higher incidence of nephrotic syndrome than non-Asian children [8]. This study aimed to estimate the frequency, severity, and type of behavioral effects of steroids in children with nephrotic syndrome from a single center.…”

Section: Introductionmentioning

confidence: 99%

The effects of corticosteroids on behavior in children with nephrotic syndrome

Hall

Thorley²,

Houtman

2003

Pediatric Nephrology

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The objective of this study was to measure the frequency and severity of the behavioral effects of high-dose oral steroid therapy in children with nephrotic syndrome. We conducted a prospective assessment of the behavior of 12 children using a standardized psychological questionnaire at the time of diagnosis and again after 4 weeks of steroid therapy. A group of control children was also assessed. There was a significant increase in the total behavior score ( P=0.03) and specifically in aggressive and poor attention behavior items in the group of nephrotic children compared with the control group. Four of the children with nephrotic syndrome developed abnormal behavior in the clinical range compared with none of the controls. In conclusion, children with nephrotic syndrome treated with high-dose oral steroids are at risk of developing clinically relevant behavioral changes.

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Section: Introductionmentioning

confidence: 99%

The effects of corticosteroids on behavior in children with nephrotic syndrome

Hall

Thorley²,

Houtman

2003

Pediatric Nephrology

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“…8 There is also evidence from both Leicester and Birmingham that steroid responsive nephrotic syndrome in childhood (a condition not usually associated with progressive renal failure) is more common in South Asian than in White populations. 9,10 …”

Section: Renal Disease Not Causing Renal Failurementioning

confidence: 99%

Ethnicity and renal disease: questions and challenges

Feehally

2003

Clinical Medicine

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-There are significant ethnic variations in the incidence of end-stage renal disease (ESRD). In the UK, the incidence of ESRD in South Asians and African Caribbeans is three times higher than in White Caucasians. This is partly explained by a high prevalence of diabetic nephropathy, but also by susceptibility to a wide range of other renal diseases. The relative contributions of genetic and environmental factors to this susceptibility are not yet well understood. The age structure of the population indicates that the prevalence of ESRD in ethnic minority populations will continue to increase more rapidly than in the White Caucasian population. Additional resources are required for renal replacement therapy in areas with substantial ethnic minority populations, taking into account the increased waiting times for cadaveric renal transplantation in these populations. Early intervention programmes to delay or prevent renal failure must be targeted to these high-risk populations.

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“…Second, evidence indicates that ethnicity or ancestry may play a role in susceptibility to idiopathic nephrotic syndrome. 3 Although ethnic groups differ in environments, lifestyles, and culture, they also differ in many genomic characteristics, including allele frequencies, linkage disequilibrium (LD), and signatures of selection. It is therefore possible that SSNS risk is mediated by specific genetic risk variants, either alone or in response to yet unidentified environmental triggers.…”

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confidence: 99%

HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome

Gbadegesin

Adeyemo

Webb

et al. 2015

Journal of the American Society of Nephrology

127

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Steroid-sensitive nephrotic syndrome (SSNS) accounts for .80% of cases of nephrotic syndrome in childhood. However, the etiology and pathogenesis of SSNS remain obscure. Hypothesizing that coding variation may underlie SSNS risk, we conducted an exome array association study of SSNS. We enrolled a discovery set of 363 persons (214 South Asian children with SSNS and 149 controls) and genotyped them using the Illumina HumanExome Beadchip. Four common single nucleotide polymorphisms (SNPs) in HLA-DQA1 and HLA-DQB1 (rs1129740, rs9273349, rs1071630, and rs1140343) were significantly associated with SSNS at or near the Bonferroni-adjusted P value for the number of single variants that were tested (odds ratio, 2.11; 95% confidence interval, 1.56 to 2.86; P=1.68310 26 (Fisher exact test). Two of these SNPs-the missense variants C34Y (rs1129740) and F41S (rs1071630) in HLA-DQA1-were replicated in an independent cohort of children of white European ancestry with SSNS (100 cases and #589 controls; P=1.42310 217). In the rare variant gene set-based analysis, the best signal was found in PLCG2 (P=7.825310 25). In conclusion, this exome array study identified HLA-DQA1 and PLCG2 missense coding variants as candidate loci for SSNS. The finding of a MHC class II locus underlying SSNS risk suggests a major role for immune response in the pathogenesis of SSNS.

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High incidence of minimal change nephrotic syndrome in Asians.

Cited by 61 publications

References 4 publications

The effects of corticosteroids on behavior in children with nephrotic syndrome

The effects of corticosteroids on behavior in children with nephrotic syndrome

Ethnicity and renal disease: questions and challenges

HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome

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