High HIV-1 prevalence and viral diversity among entry-exit populations at frontier ports of China, 2012–2016: A cross-sectional molecular epidemiology study

Wang, Haibo; Yang, Zexiao; Zhu, Hong; Mo, Qiu-Hua; Tan, Hua

doi:10.1016/j.meegid.2018.08.003

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…Female sex workers (FSWs) are at a high risk of HIV infection via heterosexual behaviour, acting as the "bridge" population of HIV transmission among the general population. The prevalence of HIV is high in FSWs in the country's border region [3][4][5]. Guangxi is a Vietnam-bordered province in China, and it has the secondhighest HIV infection rate in China [6].…”

Section: Introductionmentioning

confidence: 99%

Migrant female sex workers working at the Sino-Vietnamese border for a short time have a higher risk of HIV transmission: a consecutive cross-sectional study

et al. 2020

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Objectives: For migrant female sex workers (FSWs) at the Sino-Vietnamese border, the impact of work time in their current location on the spread of HIV/AIDS is not clear.Methods: Data were collected from the Sino-Vietnamese border cities of Guangxi, China. Migrant FSWs working in these cities were studied. FSWs who worked less than 6 months in their current location were assigned to the shortterm work group (ST FSWs), and FSWs who worked equal to or longer than 6 months in their current location were assigned to the long-term work group (LT FSWs). Logistic regression was performed to examine the impact of work time in the current location and factors associated with HIV infection. Results:Among the 1667 migrant FSWs, 586 (35.2%) and 1081 (64.9%) were assigned to the ST FSW and LT FSW groups, respectively. Compared to LT FSWs, ST FSWs were more likely to be of Vietnamese nationality, be less than 18 years old when they first engaged in commercial sex work, and have a low-level of HIV-related knowledge and had higher odds of using condoms inconsistently, having more male clients, having no regular male clients, and having a history of male clients who used aphrodisiacs but lower odds of receiving free condoms distribution and education/ HIV counselling and testing programme. The analysis of factors associated with HIV infection revealed that Vietnamese FSWs, less than 18 years old when they first engaged in commercial sex work, having no regular male clients, and having lower average charge per sex transaction were correlated with HIV infection. Conclusion:FSWs with short-term work at the Sino-Vietnamese border had a higher risk of risky sex and were correlated with HIV risk factors. Vietnamese FSWs were at higher risk of HIV infection, and they were more likely to have short-term work. More targeted HIV prevention should be designed for new FSWs who recently began working in a locality to further control the spread of HIV, particularly cross-border FSWs. © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article' s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article'

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Section: Introductionmentioning

confidence: 99%

Migrant female sex workers working at the Sino-Vietnamese border for a short time have a higher risk of HIV transmission: a consecutive cross-sectional study

et al. 2020

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“…Researchers can trace these migrating HIV strains to specific geographical regions and modes of transmission ( 2 , 3 ). In border areas, the population mobility of transnational floating populations, including high-risk HIV key populations (e.g., injection drug users and sex workers), can drive HIV transmission between countries ( 4 ). Thus, multiple studies have focused on preventing HIV transmission in these border regions.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, clustering with neighboring countries was found between 10.1% of people newly diagnosed with HIV-1 in Europe ( 6 ). As China shares borders with multiple countries, and previous research has shown that the HIV prevalence rate among transnational floating populations at Chinese frontier ports is significantly higher than the general population, prevention of HIV transmission across borders in China is critical ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the HIV infection status of this transnational population in Yunnan is mainly unknown ( 14 ). While incident cases of HIV/AIDS in Yunnan are decreasing, the proportion of newly diagnosed with HIV/AIDS in Yunnan province who are Burmese is almost 60% and increasing annually in Yunnan ( 4 ). Therefore, it is essential to identify and address migrating HIV strains spread among transnational floating populations to address the HIV epidemic in Yunnan.…”

Section: Introductionmentioning

confidence: 99%

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Frequently Transmission and Close Relationship Among Immigrants in the China–Myanmar Border Region Indicated by Molecular Transmission Analysis From a Cross-Sectional Data

Liu

Wang³

et al. 2022

Front. Med.

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BackgroundAccurate identification of molecular transmission clusters (MTCs) and understanding the dynamics of human immunodeficiency virus (HIV) transmission are necessary to develop targeted interventions to prevent HIV transmission. We evaluated the characteristics of antiretroviral therapy-naïve individuals who belonged to HIV-1 MTCs in the China–Myanmar border region to inform targeted effective HIV intervention.MethodsPhylogenetic analyses were undertaken on HIV-1 pol sequences to characterize subtypes or circulating recombinant forms and identify MTCs. MTCs were defined as those with 2 or more sequences having bootstrap support > 80% and a pairwise gene distance less than or equal to 0.03. Factors correlated with MTCs were evaluated using logistic regression analysis. The chi-square test was used to compare differences between Chinese and Burmese participants belonging to MTCs.ResultsA total of 900 people had their pol gene successfully sequenced. Twenty-one MTCs were identified and included 110 individuals (12.2%). Individuals in MTCs were more likely to be Burmese [aOR = 2.24 (95% CI: 1.33, 3.79), P = 0.003], be younger [aOR = 0.34 (95% CI: 0.20, 0.58), P < 0.001 for age 26–50 vs. 25 years or younger], have a lower CD4 T cell count [aOR = 2.86 (95% CI: 1.34, 6.11), P = 0.007 for < 200 vs. 350 or greater], and have subtypes CRF07_BC or C [CRF07_BC: aOR = 7.88 (95% CI: 3.55, 17.52), P < 0.001; C: aOR = 2.38 (95% CI: 1.23, 4.62), P = 0.010 compared to CRF01_AE]. In MTCs, Burmese were younger (89.7 vs. 57.7% for age 25 years or younger), had a lower education level (41.0 vs. 8.5% for illiterate), were more likely to be infected through injection drug use (35.9 vs. 12.7%), and had a higher proportion of subtype BC (33.3 vs. 15.5%) and CRF01_AE (20.5 vs. 8.5%) compared to Chinese (P < 0.05 for all).ConclusionBurmese participants were more likely to belong to MTCs, and most MTCs had both Burmese and Chinese participants. These data highlight the bidirectional transmission of HIV-1 frequently transmission and close relationship among immigrants in the China–Myanmar border region. Local health departments should pay more attention to HIV screening and intervention to immigrants Burmese with the characteristics of younger age, having lower CD4 T cell count and infected with HIV subtypes CRF07_ BC or C.

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“…Some viruses can lead to epidemics or pandemics, as observed throughout history such as those caused by the influenza virus [1], human immunodeficiency virus (HIV) – the aetiological agent of acquired immunodeficiency syndrome (AIDS) – and recently COVID‐19, the disease caused by the new coronavirus SARS‐CoV‐2. It is estimated that 1.8 million people are infected with HIV worldwide, with Africa and Southeast Asia being the most affected regions [2]. There were about 12 800 deaths globally due to the H1N1 Influenza A pandemic in 2009, and the highest mortality rate was registered in the South American continent, with 76.9 deaths per 10 000 inhabitants [3].…”

Section: Introductionmentioning

confidence: 99%

Antiviral therapies: advances and perspectives

Gonçalves

Barbosa

Olak

et al. 2020

Fundamemntal Clinical Pharma

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Viral infections cause high morbidity and mortality, threaten public health, and impose a socioeconomic burden. We have seen the recent emergence of SARS‐CoV‐2 (Severe Acute Respiratory Syndrome Coronavirus 2), the causative agent of COVID‐19 that has already infected more than 29 million people, with more than 900 000 deaths since its identification in December 2019. Considering the significant impact of viral infections, research and development of new antivirals and control strategies are essential. In this paper, we summarize 96 antivirals approved by the Food and Drug Administration between 1987 and 2019. Of these, 49 (51%) are used in treatments against human immunodeficiency virus (HIV), four against human papillomavirus, six against cytomegalovirus, eight against hepatitis B virus, five against influenza, six against herpes simplex virus, 17 against hepatitis C virus and one against respiratory syncytial virus. This review also describes future perspectives for new antiviral therapies such as nanotechnologies, monoclonal antibodies and the CRISPR‐Cas system. These strategies are suggested as inhibitors of viral replication by various means, such as direct binding to the viral particle, blocking the infection, changes in intracellular mechanisms or viral genes, preventing replication and virion formation. We also observed that a large number of viral agents have no therapy available and the majority of those approved in the last 32 years are restricted to some groups, especially anti‐HIV. Additionally, the emergence of new viruses and strains resistant to available antivirals has necessitated the formulation of new antivirals.

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High HIV-1 prevalence and viral diversity among entry-exit populations at frontier ports of China, 2012–2016: A cross-sectional molecular epidemiology study

Cited by 4 publications

References 26 publications

Migrant female sex workers working at the Sino-Vietnamese border for a short time have a higher risk of HIV transmission: a consecutive cross-sectional study

Migrant female sex workers working at the Sino-Vietnamese border for a short time have a higher risk of HIV transmission: a consecutive cross-sectional study

Frequently Transmission and Close Relationship Among Immigrants in the China–Myanmar Border Region Indicated by Molecular Transmission Analysis From a Cross-Sectional Data

Antiviral therapies: advances and perspectives

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