High-grade and low-grade gliomas: differentiation by using perfusion MR imaging

Role of Perfusion CT in Glioma Grading and Comparison with Conventional MR Imaging Features

“…3,8,12,14,15,48 In our study, mean nCBV of the high-and low-grade gliomas was 3.06 and 1.44, respectively (P ϭ .005). The values for the lowgrade gliomas in our study are in concordance with other perfusion studies; however, the values for the high-grade tumors are less than the values observed with MR perfusion in the literature.…”

Correlation between arterial blood volume obtained by arterial spin labelling and cerebral blood volume in intracranial tumours

“…CBF ratios obtained by ASL and DSC-MRI in low-grade (2.16 and 2.23, respectively) and high grade gliomas (3.45 and 2.69, respectively) were considerably higher in the present study than in a previous work that studied 29 gliomas grade I-IV (0.64 and 0.6, respectively, in low-grade and 1.54 and 1.28, respectively, in high-grade gliomas) [24]. Tumour-to-GM CBF ratios obtained from ASL Q2TIPS in 35 patients with, amongst others, gliomas, meningiomas and schwannomas have been reported to be 1.5 for low-grade gliomas and 2.5 for high grade gliomas [33], to be compared with 2.16 and 3.45 for grade III gliomas and glioblastomas, respectively, in the present study. Reports also include CBF from continuous ASL, in high-grade and low-grade gliomas [26], where glioma grading was based on the mean and maximum tumour blood flow and these measures were normalized to global CBF.…”

Cerebral blood flow estimation in vivo using local tissue reference functions

“…Relative parameters are more reliable because they rely on fewer assumptions (e.g., the linearity of ⌬R 2 * signals in arteries with tracer concentration) and they impose fewer methodological constraints than AIF quantification methods. Relative parameters are as useful as absolute measurements for a number of applications investigating within-patient effects, such as monitoring perfusion between sequential observations or detecting localized hemodynamic conditions (e.g., AIS) (1,4,8,(32)(33)(34). Furthermore, for conditions like acute stroke, the utility of absolute CBF thresholds are extremely limited due to their time dependence-they change with duration of hypoperfusion and can be modified by reperfusion (35).…”

“…DYNAMIC SUSCEPTIBILITY CONTRAST (DSC) perfusion MRI can provide valuable information regarding cerebral hemodynamics suitable for various neuroscience and diagnostic purposes (1)(2)(3)(4). DSC-MR acquisition involves the injection of a bolus of paramagnetic tracer followed by rapid image acquisition to measure the bolus as it passes through the brain.…”