volume 7, issue 6, P383-388 2015
DOI: 10.18632/aging.100759
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Marjorie R. Liggett, Michael J. Hoy, Michae Mastroianni, Michelle A. Mondoux

Abstract: Diet and sex are important determinants of lifespan. In humans, high sugar diets, obesity, and type 2 diabetes correlate with decreased lifespan, and females generally live longer than males. The nematode Caenorhabditis elegans is a classical model for aging studies, and has also proven useful for characterizing the response to high‐glucose diets. However, studies on male animals are lacking. We found a surprising dichotomy: glucose regulates lifespan and aging in a sex‐specific manner, with beneficial effects…

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